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Disrupted Functional Brain Connectivity and Its Association to Structural Connectivity in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
Open accessAbstract
Although anomalies in the topological architecture of whole-brain connectivity have been found to be associated with Alzheimer's disease (AD), our understanding about the progression of AD in a functional connectivity (FC) perspective is still rudimentary and few study has explored the function-structure relations in brain networks of AD patients. By using resting-state functional MRI (fMRI), this study firstly investigated organizational alternations in FC networks in 12 AD patients, 15 amnestic mild cognitive impairment (aMCI) patients, and 14 age-matched healthy aging subjects and found that all three groups exhibit economical small-world network properties. Nonetheless, we found a decline of the optimal architecture in the progression of AD, represented by a more localized modular organization with less efficient local information transfer. Our results also show that aMCI forms a boundary between normal aging and AD and represents a functional continuum between healthy aging and the earliest signs of dementia. Moreover, we revealed a dissociated relationship between the overall FC and structural connectivity (SC) in AD patients. In this study, diffusion tensor imaging tractography was used to map the structural network of the same individuals. The decreased FC-SC coupling may be indicative of more stringent and less dynamic brain function in AD patients. Our findings provided insightful implications for understanding the pathophysiological mechanisms of brain dysfunctions in aMCI and AD patients and demonstrated that functional disorders can be characterized by multimodal neuroimaging-based metrics.
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“Previous DTI and fMRI connectome studies of patients with AD have also demonstrated lower normalized clustering, small-worldness, and modularity (Brier et al., 2014; Sun et al., 2014; Supekar, Menon, Rubin, Musen, & Greicius, 2008).”
From Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer’s disease (2018) · cites this paper as Sun et al., 2014
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“However, Sun et al. (2014) observed lower structure-function coupling in connectomes of patients with AD.”
From Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer’s disease (2018) · cites this paper as Sun et al. (2014)
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Metadata
- Authors
- Sun, Y., Yin, Q., Fang, R., Yan, X., Wang, Y., Bezerianos, A., Tang, H., Miao, F., & Sun, J.
- Affiliations
- National University of Singapore (SG)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Tang, Huidong
- Miao, Fei
- Sun, Junfeng
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-05-07
- Volume
- 9
- Issue
- 5
- Pages
- e96505
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4013022
- OpenAlex
- W1998486151
- Cited by
- 122
- References
- 83
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 11 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 3
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Shanghai Jiao Tong University (YG2012MS09)
- National Key Research and Development Program of China (2011CB013304)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- Alzheimer's disease, amnestic mild cognitive impairment, functional connectivity, structural connectivity, small-world networks, brain network topology, modular organization, healthy aging, dementia continuum, diffusion tensor tractography
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amnesia, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neuropsychological Tests, Disease Progression, Diffusion Tensor Imaging, Neuroimaging, Cognitive Dysfunction
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