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Identification of Metabolites, Clinical Chemistry Markers and Transcripts Associated with Hepatotoxicity
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Various animal studies and in vitro models have identified changes in the metabolomic profile in the presence of DILI.
“Various animal studies and in vitro models have identified changes in the metabolomic profile in the presence of DILI [13,16,22,23,24,25,26,27,28,29,30,31,32,33,34,35].”
From Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM (2023) · cites this paper as [26]
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Research works printed but not linked: 27
- VJ Navarro, 2006, Drug-related hepatotoxicity, N Engl J Med, 354, 731, 10.1056/NEJMra052270 · DOI · Paper page
- FM Goodsaid, 2009, Novel biomarkers of acute kidney toxicity, Clin Pharmacol Ther, 86, 490, 10.1038/clpt.2009.149 · DOI
- F Dieterle, 2010, Urinary clusterin, cystatin c, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury, Nat Biotechnol, 28, 463, 10.1038/nbt.1622 · DOI
- VS Vaidya, 2010, Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies, Nat Biotechnol, 28, 478, 10.1038/nbt.1623 · DOI
- KJ Boudonck, 2009, Discovery of metabolomics biomarkers for early detection of nephrotoxicity, Toxicol Pathol, 37, 280, 10.1177/0192623309332992 · DOI
- V Strauss, 2009, Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies, Toxicol Lett, 191, 88, 10.1016/j.toxlet.2009.08.004 · DOI
- DG Robertson, 2011, Metabolomics in toxicology: preclinical and clinical applications, Toxicol Sci, 120, S146, 10.1093/toxsci/kfq358 · DOI
- A Zhang, 2012, Metabonomics for discovering biomarkers of hepatotoxicity and nephrotoxicity, Pharmazie, 67, 99
- H Kamp, 2012, Application of in vivo metabolomics to preclinical/toxicological studies: case study on phenytoin-induced systemic toxicity, Bioanalysis, 4, 2291, 10.4155/bio.12.214 · DOI
- U Roessner, 2000, Technical advance: simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry, Plant J, 23, 131, 10.1046/j.1365-313x.2000.00774.x · DOI
- J Huang, 2010, Genomic indicators in the blood predict drug-induced liver injury, Pharmacogenomics J, 10, 267, 10.1038/tpj.2010.33 · DOI
- J Ozer, 2008, The current state of serum biomarkers of hepatotoxicity, Toxicology, 245, 194, 10.1016/j.tox.2007.11.021 · DOI
- D Ennulat, 2010, Diagnostic performance of traditional hepatobiliary biomarkers of drug-induced liver injury in the rat, Toxicol Sci, 116, 397, 10.1093/toxsci/kfq144 · DOI
- R Temple, 2006, Hy’s law: predicting serious hepatotoxicity, Pharmacoepidemiol Drug Saf, 15, 241, 10.1002/pds.1211 · DOI
- SL Friedman, 1996, Hepatic stellate cells, Prog Liver Dis, 14, 101
- PD Berk, 1978, Hyperbilirubinemia and cholestasis, Am J Med, 64, 311, 10.1016/0002-9343(78)90061-X · DOI
- B van Ravenzwaay, 2007, The use of metabolomics for the discovery of new biomarkers of effect, Toxicol Lett, 172, 21, 10.1016/j.toxlet.2007.05.021 · DOI
- Ravenzwaay B, Cunha GC, Fabian E, Herold M, Kamp H, <etal>et al</etal>.. (2010) The Use of Metabolomics in Cancer Research. Springer-Verlag, 141–166 pp. DOI: 10.1007/978–90–481–2675–0_8. · DOI
- ME Bollard, 2001, Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)h nmr spectroscopy of urine and pattern recognition, Anal Biochem, 295, 194, 10.1006/abio.2001.5211 · DOI
- J Azmi, 2005, Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products, Xenobiotica, 35, 839, 10.1080/00498250500297940 · DOI
- Sun J, Ando Y, Ahlbory-Dieker D, Schnackenberg L, Yang X, <etal>et al</etal>.. (2013) Systems biology investigation to discover metabolic biomarkers of acetaminophen-induced hepatic injury using integrated transcriptomics and metabolomics. Journal of Molecular Biomarkers & Diagnosis S1. Available: http://omicsonline.org/systems-biology-investigation-to-discover-metabolic-biomarkers-of-acetaminophen-induced-hepatic-injury-using-integrated-transcriptomics-and-metabolomics-2155-9929.S1-002.pdf. Accessed 28 April 2014.
- DM Mosser, 2008, Exploring the full spectrum of macrophage activation, Nat Rev Immunol, 8, 958, 10.1038/nri2448 · DOI · Paper page
- MT Pritchard, 2005, Ethanol-induced liver injury: potential roles for egr-1, Alcohol Clin Exp Res, 29, 146S, 10.1097/01.alc.0000189286.81943.51 · DOI
- JT DeLigio, 2009, Early growth response 1 (egr1): a gene with as many names as biological functions, Cancer Biol Ther, 8, 1889, 10.4161/cbt.8.20.9804 · DOI
- Y Xu, 2010, Advanced glycation end product (age)-receptor for age (rage) signaling and up-regulation of egr-1 in hypoxic macrophages, J Biol Chem, 285, 23233, 10.1074/jbc.M110.117457 · DOI
- JI Leu, 2003, Impaired hepatocyte dna synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in c/ebp beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation, Mol Cell Biol, 23, 1251, 10.1128/MCB.23.4.1251-1259.2003 · DOI
- JIJ Leu, 2007, Hepatic igfbp1 is a prosurvival factor that binds to bak, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria, Genes Dev, 21, 3095, 10.1101/gad.1567107 · DOI
Cited by
Sorted by citations
Andújar-Vera, F., Alés-Palmer, M. L., Muñoz-de-Rueda, P., Iglesias-Baena, I., & Ocete-Hita, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713562 · Cited by 10
Metadata
- Authors
- Buness, A., Roth, A., Herrmann, A., Schmitz, O., Kamp, H., Busch, K., & Suter, L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-05-16
- Volume
- 9
- Issue
- 5
- Pages
- e97249
- ISSN
- 1932-6203
- PMC
- PMC4023975
- Cited by
- 26
- References
- 0
- Language
- en
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