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Cited by 48Advanced MRI Techniques and ApplicationsOsteoarthritis Treatment and MechanismsNMR spectroscopy and applications

High Resolution T1ρ Mapping of In Vivo Human Knee Cartilage at 7T

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Singh, Anup, Haris, Mohammad, Cai, Kejia, Kogan, Feliks, Hariharan, Hari, Reddy, Ravinder·2014·PLoS ONE
DOI 10.1371/journal.pone.0097486PMC PMC4022681
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Abstract

PURPOSE: Spin lattice relaxation time in rotating frame (T1ρ) mapping of human knee cartilage has shown promise in detecting biochemical changes during osteoarthritis. Due to higher field strength, MRI at 7T has advantages in term of SNR compared to clinical MR scanners and this can be used to increase in image resolution. Objective of current study was to evaluate the feasibility of high resolution T1ρ mapping of in vivo human knee cartilage at 7T MR scanner. MATERIALS AND METHODS: In this study we have used a T1ρ prepared GRE pulse sequence for obtaining high resolution (in plan resolution = 0.2 mm2) T1ρ MRI of human knee cartilage at 7T. The effect of a global and localized reference frequency and reference voltage setting on B0, B1 and T1ρ maps in cartilage was evaluated. Test-retest reliability results of T1ρ values from asymptomatic subjects as well as T1ρ maps from abnormal cartilage of two human subjects are presented. These results are compared with T1ρ MRI data obtained from 3T. RESULTS: Our approach enabled acquisition of 3D-T1ρ data within allowed SAR limits at 7T. SNR of cartilage on T1ρ weighted images was greater than 90. Off-resonance effects present in the cartilage B0, B1 and T1ρ maps obtained using global shim and reference frequency and voltage setting, were reduced by the proposed localized reference frequency and voltage setting. T1ρ values of cartilage obtained with the localized approach were reproducible. Abnormal knee cartilage showed elevated T1ρ values in affected regions. T1ρ values at 7T were significantly lower (p<0.05) compared to those obtained at 3T. CONCLUSION: In summary, by using proposed localized frequency and voltage setting approach, high-resolution 3D-T1ρ maps of in vivo human knee cartilage can be obtained in clinically acceptable scan times (<30 min) and SAR constraints, which provides the ability to characterize cartilage molecular integrity.

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  • With higher field strength T1ρ decreases.

    “and it is well known fact that with higher field strength T1ρ decreases (Singh et al., 2014).”

    From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Singh et al., 2014

    The Results section (‘T1ρ Analysis at 3T vs 7T’) reports significantly lower T1ρ values at 7T than at 3T in human knee cartilage (n = 6). That supports the direction of the comparison, but the paper does not establish an unqualified rule that T1ρ decreases with higher field strength across tissues or measurement conditions; the Discussion also notes that the spin-lock power used could have contributed to the lower values. (LLM, conf=0.86)

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  1. [1]Cohen ZA, McCarthy DM, Kwak SD, Legrand P, Fogarasi F, et al (1999) Knee cartilage topography, thickness, and contact areas from MRI: in-vitro calibration and in-vivo measurements. Osteoarthritis Cartilage 7: 95– 109. 10367018
  2. [2]Saarakkala S, Julkunen P, Kiviranta P, Makitalo J, Jurvelin JS, et al (2010) Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics. Osteoarthritis Cartilage 18: 73– 81. 19733642
  3. [3]Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F (1998) Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41: 284– 289. 9485086
  4. [4]Young AA, McLennan S, Smith MM, Smith SM, Cake MA, et al (2006) Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther 8: R41. 16469119 PMC1526595
  5. [5]Pakin SK, Cavalcanti C, La Rocca R, Schweitzer ME, Regatte RR (2006) Ultra-high-field MRI of knee joint at 7.0 T: preliminary experience. Acad Radiol 13: 1135– 1142. 16935725
  6. [6]Chang G, Wiggins GC, Xia D, Lattanzi R, Madelin G, et al (2012) Comparison of a 28-channel receive array coil and quadrature volume coil for morphologic imaging and T2 mapping of knee cartilage at 7T. J Magn Reson Imaging 35: 441– 448. 22095723 PMC3265647
  7. [7]Regatte RR, Schweitzer ME (2007) Ultra-high-field MRI of the musculoskeletal system at 7.0 T. J Magn Reson Imaging 25: 262– 269. 17260399
  8. [8]Redfield AG (1955) Nuclear Magnetic Resonance Saturation and Rotary Saturation in Solids. Physical Review 98: 13.
  9. [9]Akella SV, Regatte RR, Wheaton AJ, Borthakur A, Reddy R (2004) Reduction of residual dipolar interaction in cartilage by spin-lock technique. Magn Reson Med 52: 1103– 1109. 15508163
  10. [10]Wheaton AJ, Dodge GR, Elliott DM, Nicoll SB, Reddy R (2005) Quantification of cartilage biomechanical and biochemical properties via T1rho magnetic resonance imaging. Magn Reson Med 54: 1087– 1093. 16200568
  11. [11]Wang N, Xia Y (2012) Orientational dependent sensitivities of T2 and T1rho towards trypsin degradation and Gd-DTPA2- presence in bovine nasal cartilage. MAGMA 25: 297– 304. 22071581 PMC5682561
  12. [12]Borthakur A, Wheaton AJ, Gougoutas AJ, Akella SV, Regatte RR, et al (2004) In vivo measurement of T1rho dispersion in the human brain at 1.5 tesla. J Magn Reson Imaging 19: 403– 409. 15065163
  13. [13]Regatte RR, Akella SV, Wheaton AJ, Lech G, Borthakur A, et al (2004) 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects. Acad Radiol 11: 741– 749. 15217591
  14. [14]Wheaton AJ, Borthakur A, Kneeland JB, Regatte RR, Akella SV, et al (2004) In vivo quantification of T1rho using a multislice spin-lock pulse sequence. Magn Reson Med 52: 1453– 1458. 15562469
  15. [15]Pakin SK, Schweitzer ME, Regatte RR (2006) 3D-T1rho quantitation of patellar cartilage at 3.0 T. J Magn Reson Imaging 24: 1357– 1363. 17058202
  16. [16]Li X, Benjamin Ma C, Link TM, Castillo DD, Blumenkrantz G, et al (2007) In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3T MRI. Osteoarthritis Cartilage 15: 789– 797. 17307365 PMC2040334
  17. [17]Witschey WR 2nd, Borthakur A, Elliott MA, Mellon E, Niyogi S, et al (2007) Artifacts in T1 rho-weighted imaging: compensation for B(1) and B(0) field imperfections. J Magn Reson 186: 75– 85. 17291799 PMC1995435
  18. [18]Witschey WR, Borthakur A, Elliott MA, Mellon E, Niyogi S, et al (2007) Compensation for spin-lock artifacts using an off-resonance rotary echo in T1rhooff-weighted imaging. Magn Reson Med 57: 2– 7. 17191245 PMC2877388
  19. [19]Witschey WR, Borthakur A, Elliott MA, Fenty M, Sochor MA, et al (2008) T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI. J Magn Reson Imaging 28: 744– 754. 18777535 PMC2593793
  20. [20]Witschey WR, Borthakur A, Elliott MA, Magland J, McArdle EL, et al (2009) Spin-locked balanced steady-state free-precession (slSSFP). Magn Reson Med 62: 993– 1001. 19672947 PMC2859035
  21. [21]Witschey WR, Borthakur A, Fenty M, Kneeland BJ, Lonner JH, et al (2010) T1rho MRI quantification of arthroscopically confirmed cartilage degeneration. Magn Reson Med 63: 1376– 1382. 20432308 PMC2933515
  22. [22]Goto H, Iwama Y, Fujii M, Aoyama N, Kubo S, et al (2012) A preliminary study of the T1rho values of normal knee cartilage using 3T-MRI. Eur J Radiol 81: e796– 803. 22525597
  23. [23]Borthakur A, Wheaton A, Charagundla SR, Shapiro EM, Regatte RR, et al (2003) Three-dimensional T1rho-weighted MRI at 1.5 Tesla. J Magn Reson Imaging 17: 730– 736. 12766904
  24. [24]Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC (2009) Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 61: 1441– 1450. 19358232 PMC2860191
  25. [25]Singh A, Haris M, Cai K, Kassey VB, Kogan F, et al (2012) Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3T and 7T. Magn Reson Med 68: 588– 594. 22213239 PMC4067761
  26. [26]Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9: 671– 675. 22930834 PMC5554542
  27. [27]Firbank MJ, Coulthard A, Harrison RM, Williams ED (1999) A comparison of two methods for measuring the signal to noise ratio on MR images. Phys Med Biol 44: N261– 264. 10616158

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Authors
Singh, A., Haris, M., Cai, K., Kogan, F., Hariharan, H., & Reddy, R.
Affiliations
  • Indian Institute of Technology Delhi (IN)
  • Sidra Medical and Research Center (QA)
  • University of Illinois Chicago (US)
  • University of Pennsylvania (US)
Corresponding author
Singh, Anup
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-05-15
Volume
9
Issue
5
Pages
e97486
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0097486
PMC
PMC4022681
OpenAlex
W2006429895
Cited by
48
References
0
Citations by year
2025: 1 · 2024: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 7 · 2014: 1
FWCI
5.48
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR45404, R01AR045404, NIH-R01AR45404)
  • National Institute of Biomedical Imaging and Bioengineering (P41EB015893, 41EB015893)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
T1rho mapping, knee cartilage, 7T MRI, spin-lattice relaxation, off-resonance effects, test-retest reliability, osteoarthritis, signal-to-noise ratio, specific absorption rate
MeSH terms
Adult, Cartilage, Articular, Humans, Image Processing, Computer-Assisted, Knee, Knee Joint, Magnetic Resonance Imaging, Middle Aged, Reproducibility of Results, Osteoarthritis, Knee, Imaging, Three-Dimensional, Young Adult, Signal-To-Noise Ratio

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