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Efficacy of Eye-Movement Desensitization and Reprocessing for Patients with Posttraumatic-Stress Disorder: A Meta-Analysis of Randomized Controlled Trials
Open accessAbstract
BACKGROUND: We performed the first meta-analysis of clinical studies by investigating the effects of eye-movement desensitization and reprocessing (EMDR) therapy on the symptoms of posttraumatic stress disorder (PTSD), depression, anxiety, and subjective distress in PTSD patients treated during the past 2 decades. METHODS: We performed a quantitative meta-analysis on the findings of 26 randomized controlled trials of EMDR therapy for PTSD published between 1991 and 2013, which were identified through the ISI Web of Science, Embase, Cochrane Library, MEDLINE, PubMed, Scopus, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature electronic databases, among which 22, 20, 16, and 11 of the studies assessed the effects of EMDR on the symptoms of PTSD, depression, anxiety, and subjective distress, respectively, as the primary clinical outcome. RESULTS: The meta-analysis revealed that the EMDR treatments significantly reduced the symptoms of PTSD (g = -0.662; 95% confidence interval (CI): -0.887 to -0.436), depression (g = -0.643; 95% CI: -0.864 to -0.422), anxiety (g = -0.640; 95% CI: -0.890 to -0.390), and subjective distress (g = -0.956; 95% CI: -1.388 to -0.525) in PTSD patients. CONCLUSION: This study confirmed that EMDR therapy significantly reduces the symptoms of PTSD, depression, anxiety, and subjective distress in PTSD patients. The subgroup analysis indicated that a treatment duration of more than 60 min per session was a major contributing factor in the amelioration of anxiety and depression, and that a therapist with experience in conducting PTSD group therapy was a major contributing factor in the reduction of PTSD symptoms.
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“Additionally, multiple studies have established EMDR as an efficacious therapeutic approach for PTSD.”
From Clinical Efficacy of Psychotherapeutic Interventions for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Analysis. (2024) · cites this paper as [71]
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Measuring inconsistency in meta-analyses
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“75%, 50%, 25%, and 0% indicating high, moderate, low, and no heterogeneity, respectively [24].”
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · cited 1×
“The ORs reported in the selected RCTs were subjected to Egger’s test [21], which uses linear regression on a natural logarithmic scale to assess funnel plot asymmetry, with the level of significance set at p,0.”
MethodA Coefficient of Agreement for Nominal Scales
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“65 indicating acceptable consistency between raters and registrants [18].”
BackgroundCochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
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“The research quality of the study design, patients, outcome measures, statistical analysis, and results of the selected RCTs were assessed using the approach described by Brodaty, Green, and Koschera [19], according to the guidelines established by the Cochrane Collaboration, with a total research-quality score of six…”
MethodInfluentialBorenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
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Cognitive Therapy vs Medications in the Treatment of Moderate to Severe Depression
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“These findings are generally consistent with those of previous studies [29,36], which have reported that patients exhibited greater reductions in the symptoms of depression following cognitive therapy when treated by a therapist experienced in group therapy, compared with those treated by therapists without group-ther…”
ResultMeta‐Analysis of Psychosocial Interventions for Caregivers of People with Dementia
Brodaty, H., Green, A., & Koschera, A. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1600-0579.2003.00210.x · Cited by 952
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“Thirteen studies [6,9,14,15,16,25,26,30,32,34,35,41,42] involved the use of blinded outcome assessors, whereas 13 studies [5,7,8,10,12,13,27,28,31,37, 38,39,40] did not report blinding.”
BackgroundProlonged Exposure versus Eye Movement Desensitization and Reprocessing (EMDR) for PTSD rape victims
ROTHBAUM, B. O., Astin, M. C., & Marsteller, F. (2005) · Journal of Traumatic Stress · doi:10.1002/jts.20069 · Cited by 458 · cited 3×
“Our findings are consistent with those of other studies on depression, which have demonstrated that EMDR group therapy significantly reduced the symptoms of depression, compared with control groups [5,7,12,30].”
BackgroundMethodResult
Flagged first, then by citations
1 of the 44 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
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Items 101–200 of 222
Examination of Initial Evidence for EMDR as a Treatment for Obsessive-Compulsive Disorder
Talbot, D. (2021) · Journal of EMDR Practice and Research · doi:10.1891/emdr-d-21-00004 · Cited by 7
Treating PTSD with connected breathing: A clinical case study and theoretical implications
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The MET(T)A Protocol: Mindfulness and EMDR Treatment Template for Agencies
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Pink, J., Ghomi, M., Smart, T., & Richardson, T. H. (2022) · Journal of EMDR Practice and Research · doi:10.1891/emdr-2022-0029 · Cited by 7
Викторовна, К. Е. (2023) · Counseling Psychology and Psychotherapy · doi:10.17759/cpp.2023310304 · Cited by 8
“…или EMDR) способен значительно снижать симптомы посттравматического стрессового расстройства и субъективного дистресса, а также сопутствующие симптомы депрессии и тревоги — это убедительно доказано на большом количестве рандоми-зированных контролируемых исследований [5; 9; 11; 12; 14; 39; 44; 60].”
InfluentialJebelli, F., Maaroufi, M., Maracy, M. R., & Molaeinezhad, M. (2017) · Sexual & Relationship Therapy · doi:10.1080/14681994.2017.1323075 · Cited by 7
“, 2015) rather than retrieving and integrating information from previous experiences into a positive emotional and cognitive model (Chen et al., 2014).”
BackgroundThe Effectiveness of EMDR With Individuals Experiencing Substance Use Disorder: A Meta-Analysis
Logsdon, E., Cornelius‐White, J. H. D., & Kanamori, Y. (2023) · Journal of EMDR Practice and Research · doi:10.1891/emdr-2022-0046 · Cited by 9
“This finding is consistent with those found by Chen et al. (2014 2021) d = 1.07, providing additional support for the use of EMDR with those with SUD experiencing depressive and PTSD symptoms.”
BackgroundMethodResultInfluentialThe neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment
Agbaria, L., Mirzaei, F., A'amar, N. O., Raba, F. T., Papazian, G., Bhatnagar, K., Sirimanne, N., Ayoubkhan, A. A., Thilagendra, A. G., & Gupta, A. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.009 · Cited by 7
Crisis Intervention in the Acute Stage after Trauma
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“Another meta-analysis of RCTs affirmed EMDR significantly attenuated the symptoms of PTSD, anxiety and depression in subjects with PTSD (Chen et al., 2014).”
Covers, M. L. V., de Jongh, A., Huntjens, R. J. C., de Roos, C., van den Hout, M., & Bicanic, I. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1632021 · Cited by 11
Altmeyer, S., Wollersheim, L., Kilian-Hütten, N., Behnke, A., Hofmann, A., & Tumani, V. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.937204 · Cited by 6
“Eye Movement Desensitization and Reprocessing (EMDR) therapy was introduced in 1987 by Francine Shapiro as a treatment for post-traumatic stress disorder (PTSD).”
InfluentialHaddad, R. H., Alhusamiah, B. K., Haddad, R. H., Hamdan‐Mansour, A. M., Abuhashish, Y. H., & Alshraideh, J. A. (2024) · Mental Health and Social Inclusion · doi:10.1108/mhsi-04-2024-0057 · Cited by 4
Intensive trauma-focused therapy with victims of crime
Greenwald, R., Camden, A. A., Gamache, N., Lasser, K., Chapman, R., & Rattner, B. (2020) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2020.100146 · Cited by 6
“…or weekly therapy comparison condition; however, our effect sizes in the d = 1.03–1.87 range are consistent with the range of those reported in other EMDR treatment studies (e.g., g = .96, Chen et al., 2014; g = 1.24, Ehring et al., 2014), in which treatment was delivered in non-intensive formats.”
InfluentialAdalı, S., Yavuz, B. A., Demir, M., & Öztürk, C. Ş. (2025) · Afet ve Risk Dergisi · doi:10.35341/afet.1422407 · Cited by 5
Miccoli, M., & Poli, A. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1369216 · Cited by 6
de Vogel, V., Depla, J., & Vos, M. K. (2025) · Social Sciences · doi:10.3390/socsci14030124 · Cited by 4
Harris, H., Urdaneta, V., Triana, V., Vo, C. S., Walden, D., & Myers, D. R. (2018) · Open Journal of Social Sciences · doi:10.4236/jss.2018.611015 · Cited by 5
“[33] found that the studied disorders and symptoms were significantly reduced with effect sizes that were moderate to large, supporting EMDR as an optimal psychotherapy for patients with PTSD.”
BackgroundVibro-motor Reprocessing Therapy towards Managing Motion Sickness Reduction: Evidence from EEG
Molefi, E., Palaniappan, R., & McLoughlin, I. V. (2022) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc48229.2022.9871336 · Cited by 4
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Haddad, R. H., Price, M. M., Haddad, R. H., Abuejheisheh, A. J., Abuhashish, Y. H., & Hamdan‐Mansour, A. M. (2025) · Chronic Stress · doi:10.1177/24705470251352627 · Cited by 3
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Cornil, L., & Limbergen, O. V. (2025) · Journal of EMDR Practice and Research · doi:10.34133/jemdr.0013 · Cited by 3
Lothes, J. E., II, & Hall, M. (2024) · Counseling Outcome Research and Evaluation · doi:10.1080/21501378.2024.2437990 · Cited by 3
“For example, it may be synergistic for patients to enroll in a DBT-PH program or IOP to supplement their PTSD treatments such as prolonged exposure, cognitive processing therapy, or EMDR (Gratz et al., 2020; Sciarrino et al., 2020).”
Linguistic changes during EMDR sessions: A preliminary single‐case study
Cardazzone, E., Gallucci, M., Callerame, C., Cussino, M., Gelo, O. C. G., Pasca, P., & Zaccagnino, M. (2021) · Counselling and Psychotherapy Research · doi:10.1002/capr.12394 · Cited by 5
Post-traumatic Stress Disorder
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Solomon, R. M., & Maxfield, L. (2019) · Journal of EMDR Practice and Research · doi:10.1891/1933-3196.13.3.158 · Cited by 3
“It has established efficacy in the treatment of posttraumatic stress disorder (PTSD) and some preliminary evidence for effectiveness with a wide range of clinical disorders (Chen et al., 2014; Valiente-Gómez et al., 2017).”
BackgroundMorales‐Rivero, A., Crail‐Meléndez, D., Reyes‐Santos, L., Bisanz, E., Bisanz, J., Ruíz-Chow, Á. A., & Chavarria‐Medina, M. M. (2024) · Brain and Behavior · doi:10.1002/brb3.70063 · Cited by 3
“Other interventions, such as eye movement desensitization and reprocessing therapy (EMDR), depend on the experience of the therapist (Chen et al. 2014), whereas no prior experience is required in our application.”
BackgroundTrauma Resolution: A Healing Journey Through EMDR Therapy
Fernández, I., Gallina, E., & Solomon, R. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-71904-2_16 · Cited by 4
The use of EMDR in positive verbal material: results from a patient study
Matthijssen, S. J. M. A., & van den Hout, M. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.30119 · Cited by 3
“intervention for posttraumatic stress disorder (PTSD; see Chen et al. (2014) for a recent meta-analysis) proven”
BackgroundPosttraumatic Stress Disorder and Veterans: Finding Hope and Supporting Healing
Fogger, S. A., Moore, R. L., & Pickett, L. (2016) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2016.07.014 · Cited by 3
Anxiety Reduction and Improved Concentration in Schoolchildren through Wingwave® Coaching
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Editorial: Present and future of EMDR in clinical psychology and psychotherapy, volume II
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“EMDR (Shapiro, 2018) has been demonstrated to be effective in the treatment of traumatic sequelae, especially PTSD (Bisson, et al ., 2013; Chen et al., 2014; Ho & Lee, 2012; Lee & Cuijpers, 2013; Rodenburg et al., 2009; Seidler & Wagner, 2006; Watts et al., 2013).”
Butterfield, M. (2022) · Wiley eBooks · doi:10.1002/9781119701170.ch43 · Cited by 2
Meredith, F., Banting, R., Wilcox, D., & Paskell, R. (2023) · Journal of EMDR Practice and Research · doi:10.1891/emdr-2022-0058 · Cited by 2
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“…report a marked reduction in the intensity of both the vividness and emotional charge associated with their traumatic experiences (Calancie et al., 2018), achieved through the desensitization of the cognitive, emotional and physical aspects of distress (Chen et al., 2014; Rousseau et al., 2020).”
Factors related to recovery after sexual violence: a scoping review
Fayaz, I. (2025) · Journal of Sexual Aggression · doi:10.1080/13552600.2025.2517034 · Cited by 1
EMDR for PTSD treatment in military context: a case study of Cyprus
Efthymiou, S. A., & Hadjipanayi, V. (2025) · Journal of Aggression Conflict and Peace Research · doi:10.1108/jacpr-03-2025-0993 · Cited by 1
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Szemmozgásos traumafeldolgozás (EMDR-terápia): Hatás, hatásmechanizmus, hatásosság
Judit Szigeti, F. (2018) · Mentálhigiéné és Pszichoszomatika · doi:10.1556/0406.19.2018.011 · Cited by 3
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Is there a place for EMDR in neurology?
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Christian, A., Grey, A. E., & Sorg, T. (2015) · UST Research Online (University of St. Thomas - Minnesota)
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Abordagens contemporâneas nas ciências da saúde
Silva, B. D. R., Mariano, L. M. F. D. H., de Oliveira, F. D. A. M., Netto, P. R. D. S., Parreira, J. R., de Almeida, W. B., dos Santos, D. M., Lima, V. D. S. B., Mendonça, A. M. B., Santos, L. H. S., et al. (2021) · Brazilian Journals Editora eBooks · doi:10.35587/brj.ed
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Srikosai, S., Khamfou, C., Thakham, A., Wongmueang, J., Thippunya, K., Wongpothi, U., & Tailangkha, P. (2023) · INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH · doi:10.36106/ijsr/7832526
Gil‐Jardine, C., Joboory, S. A., Saint-Jammes, J. T., Durand, G., Brunschwig, R., Catoire, P., Tellier, É., Ribereau‐Gayon, R., Galinski, M., Salmi, L., et al. (2023) · medRxiv · doi:10.1101/2023.05.11.23289838
“Therefore, this should remain a hypothesis, but it is also indicative of the need to carefully control the level of training provided to EMDR therapists because the short training period may have been insufficient.(27) Having less experienced and/or trained psychologists might also have reduced patient adherence to th…”
BackgroundTraumatisme du deuil et thérapie par EMDR en unité de soins palliatifs : retour d’expérience
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“Daugiausia EMDR padėjo reikšmingai sumažinti depresijos, nerimo bei subjektyviai jaučiamo bendro distreso simptomus [19].”
BackgroundTan, F., Zhao, S., Fan, T., Yao, S., & Lan, X. (2023) · Journal of Anesthesia and Translational Medicine · doi:10.58888/2957-3912-2023-04-004
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Mieux comprendre la thérapie EMDR
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Traumatherapie in sieben Stufen
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Breaking the Cycle: Interventions for Healing and Recovery Among Offenders with Developmental Trauma
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Resilience in the face of Trauma and PTSD
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Non-invasive Brain Stimulation, Brain Regions, and Use in Trauma and Stress Related Disorders
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Non-invasive Brain Stimulation, Brain Regions, and Use in Trauma and Stress Related Disorders
Sá, K. N., de Oliveira, L. A. B., Nogueira, M. G., Sá, M. N., Baptista, R. F., & Gonçalves, C. H. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_12
Metadata
- Authors
- Chen, Y.-R., Hung, K.-W., Tsai, J.-C., Chu, H., Chung, M.-H., Chen, S.-R., Liao, Y.-M., Ou, K.-L., Chang, Y.-C., & Chou, K.-R.
- Affiliations
- Taoyuan Armed Forces General Hospital (TW)
- Yuan's General Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Tri-Service General Hospital (TW)
- Taipei Medical University (TW)
- Tamkang University (TW)
- Taipei Medical University Hospital (TW)
- Corresponding author
- Chou, Kuei-Ru
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-07
- Volume
- 9
- Issue
- 8
- Pages
- e103676
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4125321
- OpenAlex
- W2069381491
- Cited by
- 222
- References
- 44
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 19 · 2023: 18 · 2022: 14 · 2021: 34 · 2020: 25 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 11 · 2015: 6
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Taipei Medical University Repository (submittedVersion)
- Tamkang University Institutional Repository (TKUIR) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Council
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- EMDR, post-traumatic stress disorder, depression, anxiety, subjective distress, treatment duration, therapist experience, group therapy, psychotherapy efficacy
- MeSH terms
- Adult, Humans, Middle Aged, Regression Analysis, Stress Disorders, Post-Traumatic, Randomized Controlled Trials as Topic, Treatment Outcome, Eye Movement Desensitization Reprocessing
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