The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Tannic Acid Modified Silver Nanoparticles Show Antiviral Activity in Herpes Simplex Virus Type 2 Infection
Open accessAbstract
The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and in vivo. The antiviral activity of tannic acid modified silver nanoparticles was size-related, required direct interaction and blocked virus attachment, penetration and further spread. All tested tannic acid modified silver nanoparticles reduced both infection and inflammatory reaction in the mouse model of HSV-2 infection when used at infection or for a post-infection treatment. Smaller-sized nanoparticles induced production of cytokines and chemokines important for anti-viral response. The corresponding control buffers with tannic acid showed inferior antiviral effects in vitro and were ineffective in blocking in vivo infection. Our results show that tannic acid modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.
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Cites
Antimicrobial properties of tannins
Scalbert, A. (1991) · Phytochemistry · doi:10.1016/0031-9422(91)83426-l · Cited by 2,321
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 1×
“IL-6 supports differentiation and proliferation of B cells and T cells [62] and both HSV type 1 and type 2 are potent inducers of IL-6 [63].”
BackgroundViral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
Akhtar, J., & Shukla, D. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07402.x · Cited by 292
Cited by
Zhang, X.-F., Liu, Z.-G., Shen, W., & Gurunathan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091534 · Cited by 3,220
Ninan, N., Forget, A., Shastri, V. P., Voelcker, N. H., & Blencowe, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10491 · Cited by 676
Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic
Weiss, C., Carriere, M., Fusco, L., Capua, I., Regla-Nava, J. A., Pasquali, M., Scott, J. A., Vitale, F., Unal, M. A., Mattevi, C., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c03697 · Cited by 601
Yang, X. X., Li, C. M., & Huang, C. Z. (2016) · Nanoscale · doi:10.1039/c5nr07918g · Cited by 294
Metadata
- Authors
- Orlowski, P., Tomaszewska, E., Gniadek, M., Baska, P., Nowakowska, J., Sokolowska, J., Nowak, Z., Donten, M., Celichowski, G., Grobelny, J., & Krzyzowska, M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-12
- Volume
- 9
- Issue
- 8
- Pages
- e104113
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2089676546
- Cited by
- 211
- References
- 3
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Orlowski, P., Tomaszewska, E., Gniadek, M., Baska, P., Nowakowska, J., Sokolowska, J., Nowak, Z., Donten, M., Celichowski, G., Grobelny, J., & Krzyzowska, M. (2014). Tannic Acid Modified Silver Nanoparticles Show Antiviral Activity in Herpes Simplex Virus Type 2 Infection. PLoS ONE. https://doi.org/10.1371/journal.pone.0104113
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