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Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked Hydrogel
Open accessAbstract
Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked (ADA-GEL) hydrogel was synthesized through covalent crosslinking of alginate di-aldehyde (ADA) with gelatin that supported cell attachment, spreading and proliferation. This study highlights the evaluation of the physico-chemical properties of synthesized ADA-GEL hydrogels of different compositions compared to alginate in the form of films. Moreover, in vitro cell-material interaction on ADA-GEL hydrogels of different compositions compared to alginate was investigated by using normal human dermal fibroblasts. Viability, attachment, spreading and proliferation of fibroblasts were significantly increased on ADA-GEL hydrogels compared to alginate. Moreover, in vitro cytocompatibility of ADA-GEL hydrogels was found to be increased with increasing gelatin content. These findings indicate that ADA-GEL hydrogel is a promising material for the biomedical applications in tissue-engineering and regeneration.
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The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Cited by
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Self-citationUtech, S., Prodanovic, R., Mao, A. S., Ostafe, R., Mooney, D. J., & Weitz, D. A. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500021 · Cited by 366
Advancing bioinks for 3D bioprinting using reactive fillers: a review
Heid, S., & Boccaccini, A. R. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.040 · Cited by 224
Self-citationNatural Polymers for Organ 3D Bioprinting
Liu, F., Chen, Q., Liu, C., Ao, Q., Tian, X., Fan, J., Tong, H., & Wang, X. (2018) · Polymers · doi:10.3390/polym10111278 · Cited by 170
Matrix stiffness regulates microvesicle-induced fibroblast activation
Schwager, S. C., Bordeleau, F., Zhang, J., Antonyak, M. A., Cerione, R. A., & Reinhart-King, C. A. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00418.2018 · Cited by 50
Metadata
- Authors
- Sarker, B., Singh, R., Silva, R., Roether, J. A., Kaschta, J., Detsch, R., Schubert, D. W., Cicha, I., & Boccaccini, A. R.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-09-30
- Volume
- 9
- Issue
- 9
- Pages
- e107952
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2143637133
- Cited by
- 268
- References
- 1
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sarker, B., Singh, R., Silva, R., Roether, J. A., Kaschta, J., Detsch, R., Schubert, D. W., Cicha, I., & Boccaccini, A. R. (2014). Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked Hydrogel. PLoS ONE. https://doi.org/10.1371/journal.pone.0107952
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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