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Cited by 1703D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

Natural Polymers for Organ 3D Bioprinting

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Liu, Fan, Chen, Qiuhong, Liu, Chen, Ao, Qiang, Tian, Xiaohong, Fan, Jun, Tong, Hao, Wang, Xiaohong·2018·Polymers
DOI 10.3390/polym10111278PMC PMC6401941
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Abstract

Three-dimensional (3D) bioprinting, known as a promising technology for bioartificial organ manufacturing, has provided unprecedented versatility to manipulate cells and other biomaterials with precise control their locations in space. Over the last decade, a number of 3D bioprinting technologies have been explored. Natural polymers have played a central role in supporting the cellular and biomolecular activities before, during and after the 3D bioprinting processes. These polymers have been widely used as effective cell-loading hydrogels for homogeneous/heterogeneous tissue/organ formation, hierarchical vascular/neural/lymphatic network construction, as well as multiple biological/biochemial/physiological/biomedical/pathological functionality realization. This review aims to cover recent progress in natural polymers for bioartificial organ 3D bioprinting. It is structured as introducing the important properties of 3D printable natural polymers, successful models of 3D tissue/organ construction and typical technologies for bioartificial organ 3D bioprinting.

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  • Natural polymers are obtained from natural materials and provide a guarantee of natural structure, biomimetic and bioactive nature.

    “Natural polymers (biopolymers) are obtained from natural materials and provide a guarantee of natural structure, biomimetic and bioactive nature [42].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [42]

    Section 2, “Properties of Natural Polymers” (page unavailable), says natural polymers occur in nature and that their solutions or hydrogels can provide a mild biomimetic environment and facilitate cellular activities. It does not say that natural origin guarantees a natural structure or that every natural polymer is inherently biomimetic and bioactive. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Liu, F., Chen, Q., Liu, C., Ao, Q., Tian, X., Fan, J., Tong, H., & Wang, X.
Affiliations
China Medical University (CN)
Corresponding author
Wang, Xiaohong
ORCID
Venue
Polymers
Publisher
MDPI AG
Published
2018-11-16
Volume
10
Issue
11
Pages
1278
ISSN
2073-4360 (ISSN-L)
DOI
10.3390/polym10111278
PMC
PMC6401941
OpenAlex
W2901587830
Cited by
170
References
4
Citations by year
2026: 8 · 2025: 16 · 2024: 35 · 2023: 20 · 2022: 33 · 2021: 28 · 2020: 19 · 2019: 11
FWCI
1.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Polymers (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the 2017 Discipline Promotion Project of China Medical University (CMU) (3110117049)
  • the National Natural Science Foundation of China (NSFC) (81571832 & 81271665 & 31600793 & 81571919)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
3D bioprinting, natural polymers, bioartificial organs, hydrogels, cell loading, neural network construction, tissue engineering

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