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Cited by 64Pancreatic function and diabetesDiabetes and associated disordersDevelopmental Biology and Gene Regulation

A Conserved Rule for Pancreatic Islet Organization

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Hoang, Danh-Tai, Matsunari, Hitomi, Nagaya, Masaki, Nagashima, Hiroshi, Millis, J. Michael, Witkowski, Piotr, Periwal, Vipul, Hara, Manami +1 more·2014·PLoS ONE
DOI 10.1371/journal.pone.0110384PMC PMC4211668
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Abstract

Morphogenesis, spontaneous formation of organism structure, is essential for life. In the pancreas, endocrine α, β, and δ cells are clustered to form islets of Langerhans, the critical micro-organ for glucose homeostasis. The spatial organization of endocrine cells in islets looks different between species. Based on the three-dimensional positions of individual cells in islets, we computationally inferred the relative attractions between cell types, and found that the attractions between homotypic cells were slightly, but significantly, stronger than the attractions between heterotypic cells commonly in mouse, pig, and human islets. The difference between α-β cell attraction and β-β cell attraction was minimal in human islets, maximizing the plasticity of islet structures. Our result suggests that although the cellular composition and attractions of pancreatic endocrine cells are quantitatively different between species, the physical mechanism of islet morphogenesis may be evolutionarily conserved.

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  • In silico modelling of human islet architecture shows that the fraction of δ-cells in direct contact with at least one β-cell remains greater than 90% until more than 75% of β-cells have been deleted.

    “This remained >90% until >75% of the β-cells had been deleted (Fig. 4j).”

    From Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes (2024) · cites this paper as [40]

    The Results section on spatial organization of δ cells examines human islet structure and inferred cell attractions, but does not report how many δ-cells remain in contact with a β-cell after β-cell deletion. Searches for 75% deletion and β-cell loss found no such simulation or >90% contact threshold in our copy. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 31

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Authors
Hoang, D.-T., Matsunari, H., Nagaya, M., Nagashima, H., Millis, J. M., Witkowski, P., Periwal, V., Hara, M., & Jo, J.
Affiliations
  • Asia Pacific Center for Theoretical Physics (KR)
  • Meiji University (JP)
  • University of Chicago (US)
  • National Institutes of Health (US)
  • Pohang University of Science and Technology (KR)
Corresponding author
  • Hara, Manami
  • Jo, Junghyo
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-10-28
Volume
9
Issue
10
Pages
e110384
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0110384
PMC
PMC4211668
OpenAlex
W2060603728
Cited by
64
References
4
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 2
FWCI
4.96
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • Knowledge@UChicago (University of Chicago) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • University of Chicago
Funders
  • University of Chicago
  • Kovler Family Foundation
  • Ministry of Education, Science and Technology
  • Max-Planck-Gesellschaft
  • National Institutes of Health (UL1TR000430, DK020595, DK072473, AG-042151)
  • Diabetes Research and Training Center (AG-042151, DK-072473)
  • National Institute on Aging (R03AG042151, AG-042151)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK020595, DK072473, P60DK020595, U01DK072473, P30DK020595)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
pancreatic islets, heterotypic cell interactions, alpha cells, pancreatic beta cells, delta cells, species differences, evolutionary conservation
MeSH terms
Algorithms, Animals, Cell Communication, Humans, Islets of Langerhans, Models, Theoretical, Morphogenesis, Swine, Mice

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