First-in-human trial of a novel suprachoroidal retinal prosthesis
Open accessAbstract
UNLABELLED: Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration. TRIAL REGISTRATION: Clinicaltrials.gov NCT01603576.
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Suprachoroidal prostheses have good mechanical stability without fixation with retinal tacks and, like epiretinal prostheses, good heat dissipation capacity and allow the insertion of large arrays.
“Like subretinal prostheses, they have good mechanical stability without fixation with retinal tacks [56,58] and, like epiretinal prostheses, they have good heat dissipation capacity and allow the insertion of large arrays [57].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [57]
The 22-electrode suprachoroidal device had a good safety profile and achieved Landolt-C acuity of about 2.62 logMAR (20/8397 Snellen).
“Clinical trial of the 22 electrode device achieved good safety profile and Landolt-C visual acuity equivalent of around 2.62 logMAR (20/8397 Snellen) [Ayton 2014].”
From Correcting visual loss by genetics and prosthetics (2020) · cites this paper as Ayton 2014
Most clinical neural interfaces function in a monopolar configuration with a common and distant return ground placed several millimetres away.
“Most clinical neural interfaces function in a monopolar configuration with a common and distant return ground placed several millimetres away [9-12].”
From Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation (2022) · cites this paper as [10]
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References 47 · Cited by 333
- Authors
- Ayton, L. N., Blamey, P. J., Guymer, R. H., Luu, C. D., Nayagam, D. A. X., Sinclair, N. C., Shivdasani, M. N., Yeoh, J., McCombe, M. F., Briggs, R. J., Opie, N. L., Villalobos, J., Dimitrov, P. N., Varsamidis, M., Petoe, M. A., McCarthy, C. D., Walker, J. G., Barnes, N., Burkitt, A. N., Williams, C. E., Shepherd, R. K., Allen, P. J., & for the Bionic Vision Australia Research Consortium
- Affiliations
- The University of Melbourne (AU)
- Bionics Institute (AU)
- Australian National University (AU)
- Corresponding author
- Ayton, Lauren N.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-12-18
- Volume
- 9
- Issue
- 12
- Pages
- e115239
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4270734
- OpenAlex
- W2107454866
- Cited by
- 333
- References
- 47
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 13 · 2023: 20 · 2022: 30 · 2021: 27 · 2020: 40 · 2019: 25 · 2018: 37 · 2017: 38 · 2016: 51 · 2015: 13 · 2014: 1
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- ANU Open Research (Australian National University) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (cc-by)
- Funders
- John T. Reid Charitable Trusts
- Retina Australia
- David and Elaine Potter Foundation
- Australian Government
- Ian Potter Foundation
- La Trobe University
- University of New South Wales
- University of Western Sydney
- Deakin University
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (529923, 529905)
- State Government of Victoria
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council (529905, 529923)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Keywords
- retinal prosthesis, retinitis pigmentosa, vision restoration, implant safety, blind patients
- MeSH terms
- Choroid, Female, Humans, Male, Middle Aged, Postoperative Complications, Retinitis Pigmentosa, Sclera, Ophthalmologic Surgical Procedures, Visual Prosthesis
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