Tumor Cell Targeting by Iron Oxide Nanoparticles Is Dominated by Different Factors In Vitro versus In Vivo
Open accessAbstract
Realizing the full potential of iron oxide nanoparticles (IONP) for cancer diagnosis and therapy requires selective tumor cell accumulation. Here, we report a systematic analysis of two key determinants for IONP homing to human breast cancers: (i) particle size and (ii) active vs passive targeting. In vitro, molecular targeting to the HER2 receptor was the dominant factor driving cancer cell association. In contrast, size was found to be the key determinant of tumor accumulation in vivo, where molecular targeting increased tumor tissue concentrations for 30 nm but not 100 nm IONP. Similar to the in vitro results, PEGylation did not influence in vivo IONP biodistribution. Thus, the results reported here indicate that the in vitro advantages of molecular targeting may not consistently extend to pre-clinical in vivo settings. These observations may have important implications for the design and clinical translation of advanced, multifunctional, IONP platforms.
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Animal models can imitate the TME to provide essential information regarding tumor growth and tumor response to drug compounds in vivo for the study of pharmacokinetics and mechanism of action after drug treatment.
“Alternatively, animal models, as the gold standard in cancer biology, can imitate the TME to provide essential information regarding tumor growth and tumor response to drug compounds in vivo for the study of the pharmacokinetics and mechanism of action after drug treatment26–30.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [26]
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Research works printed but not linked: 1
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Tumor-on-a-chip: from bioinspired design to biomedical application
Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works
- Authors
- NDong, C., Tate, J. A., Kett, W. C., Batra, J., Demidenko, E., Lewis, L. D., Hoopes, P. J., Gerngross, T. U., & Griswold, K. E.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Griswold, Karl E.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-02-19
- Volume
- 10
- Issue
- 2
- Pages
- e0115636
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4335054
- OpenAlex
- W2077045805
- Cited by
- 50
- References
- 51
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 6
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Dartmouth College
- National Cancer Institute (U54CA151662, P30CA023108)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- iron oxide nanoparticles, tumor cell targeting, breast cancer, HER2 receptor, nanoparticle size, PEGylation, tissue distribution, tumor accumulation, in vivo and in vitro comparison, MRI contrast agents
- MeSH terms
- Animals, Breast Neoplasms, Ferric Compounds, Humans, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Mice, Nanoparticles
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