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Cited by 169Mosquito-borne diseases and controlDiptera species taxonomy and behaviorViral Infections and Vectors

New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences

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Moureau, Gregory, Cook, Shelley, Lemey, Philippe, Nougairede, Antoine, Forrester, Naomi L., Khasnatinov, Maxim, Charrel, Remi N., Firth, Andrew E. +2 more·2015·PLOS ONE
DOI 10.1371/journal.pone.0117849PMC PMC4342338
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Abstract

To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with Culex spp. mosquitoes. We analyze these data, in conjunction with a comprehensive collection of flavivirus genomes, to characterize flavivirus evolutionary and biogeographic history in unprecedented detail and breadth. Based on the presumed introduction of yellow fever virus into the Americas via the transatlantic slave trade, we extrapolated a timescale for a relevant subset of flaviviruses whose evolutionary history, shows that different Culex-spp. associated flaviviruses have been introduced from the Old World to the New World on at least five separate occasions, with 2 different sets of factors likely to have contributed to the dispersal of the different viruses. We also discuss the significance of programmed ribosomal frameshifting in a central region of the polyprotein open reading frame in some mosquito-associated flaviviruses.

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  • Viruses that are exclusively hosted by mammals are evolutionarily related to either tick- or mosquito-borne viruses.

    “The viruses that are exclusively hosted by mammals (rodents and bats) are evolutionarily related to either tick-or mosquito-borne viruses (Moureau et al., 2015).”

    From Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias (2016) · cites this paper as Moureau et al., 2015

    The Results (NKVs; A timed evolutionary perspective) place bat-associated no-known-vector viruses within a mosquito-borne clade and describe a rodent-associated lineage that gave rise to both no-known-vector and arthropod-borne lineages. The Introduction describes these viruses as primarily associated with rodents or bats, but does not establish that they are exclusively hosted by mammals. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Insect-specific-like flaviviruses likely evolved from mosquito-borne viruses.

    “insect-specific-like flaviviruses, which likely evolved from mosquito-borne viruses (Blitvich and Firth, 2015;Moureau et al., 2015).”

    From Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias (2016) · cites this paper as Moureau et al., 2015

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Authors
Moureau, G., Cook, S., Lemey, P., Nougairede, A., Forrester, N. L., Khasnatinov, M., Charrel, R. N., Firth, A. E., Gould, E. A., & de Lamballerie, X.
Affiliations
  • Natural History Museum (GB)
  • KU Leuven (BE)
  • The University of Texas Medical Branch at Galveston (US)
  • University of Cambridge (GB)
  • Aix-Marseille Université (FR)
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2015-02-26
Volume
10
Issue
2
Pages
e0117849
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0117849
PMC
PMC4342338
OpenAlex
W2008026660
Cited by
169
References
2
Citations by year
2026: 9 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 19 · 2018: 17 · 2017: 19 · 2016: 14 · 2015: 7
FWCI
20.38
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • NERC Open Research Archive (Natural Environment Research Council) (acceptedVersion)
  • Keele Research Repository (Keele University) (submittedVersion, cc-by)
  • Lirias (submittedVersion, cc-by)
  • HAL AMU (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Aix-Marseille Université
  • Wellcome Trust (088789, 228292)
  • European Commission (261504, 278433, 228292, 260644)
  • École des Hautes Études en Santé Publique
  • Natural Environment Research Council (CEH010010)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Diptera species taxonomy and behavior
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
Keywords
flavivirus, flavivirus evolution, historical biogeography, transatlantic slave trade, programmed ribosomal frameshifting, flavivirus phylogeny
MeSH terms
Base Sequence, Flavivirus, Molecular Sequence Data, Phylogeny, Open Reading Frames, Genome, Viral, Frameshifting, Ribosomal, Evolution, Molecular, Phylogeography

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