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Identification and Functional Analysis of Genome Mutations in a Fluoride-Resistant Streptococcus mutans Strain
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In a fluoride-resistant derivative of S. mutans UA159, mutations in the promoter region 5′ to 1290 contribute to constitutive expression of ORF 1290 and other genes in the operon including ORF 1289.
“in a fluoride-resistant derivative of S. mutans UA159, mutations in the promoter region 5′ to 1290 contribute to constitutive expression of ORF 1290 and other genes in the operon including ORF 1289 (53).”
From Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models (2024) · cites this paper as [53]
The gene encoding chorismate mutase is one of the most common genes in fluoride exporter gene neighborhoods, and its expression is upregulated in fluoride-resistant S. mutans together with the fluoride exporters in the same operon.
“The gene encoding chorismate mutase, a key enzyme in the biosynthesis of aromatic amino acids, is one of the most common genes in fluoride exporter gene neighborhoods67, and its expression is upregulated in fluoride-resistant S. mutans together with the fluoride exporters in the same operon91.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [91]
In fluoride-resistant S. mutans, pyruvate kinase is heavily mutated.
“In this same fluoride-resistant S. mutans strain, pyruvate kinase, the enzyme that directs PEP towards pyruvate oxidation and the TCA cycle, is heavily mutated91, suggesting that other PEP-consuming biosynthetic pathways, such as aromatic amino acid production, might be favored under fluoride stress.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [91]
A fluoride-resistant strain of S. mutans exhibits constitutive expression of CLCF genes, and a single nucleotide polymorphism in the intergenic region 5′ to the operon was linked to this mechanism.
“A fluoride-resistant strain of S. mutans exhibits a constitutive expression of the CLCF genes, and a single nucleotide polymorphism in the intergenic region 5′ to the operon was linked to this mechanism91.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [91]
Constitutive expression of fluoride exporters is one naturally evolved response that improves bacterial fluoride tolerance.
“Constitutive expression of fluoride exporters is one naturally evolved response that improves bacterial fluoride tolerance91.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [91]
Genes encoding proteins in the CLCF clade are overexpressed in fluoride-resistant Streptococcus mutans.
“Genes encoding proteins in the CLCF clade are overexpressed in fluoride-resistance Streptococcus mutans (47)”
From Membrane exporters of fluoride ion (2021) · cites this paper as [47]
Some bacteria have evolved protective mechanisms of fluoride resistance.
“Fortunately, some bacteria have evolved protective mechanisms of fluoride resistance (Chouhan et al., 2012; Liao et al., 2015; Mukherjee et al., 2017; Chellaiah et al., 2021), and these systems would need to be very effective to protect the cell while biodegrading even low μM levels of polyfluorinated compounds.”
From Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances (2022) · cites this paper as Liao et al., 2015
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Cited by
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Wackett, L. P. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.13928 · Cited by 165
Stockbridge, R. B., & Wackett, L. P. (2024) · Nature Communications · doi:10.1038/s41467-024-49018-1 · Cited by 80
Membrane exporters of fluoride ion
McIlwain, B. C., Ruprecht, M. T., & Stockbridge, R. B. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-071520-112507 · Cited by 69
Banerjee, A., Kang, C.-Y., An, M., Koff, B. B., Sunder, S., Kumar, A., Tenuta, L. M. A., & Stockbridge, R. B. (2024) · mBio · doi:10.1128/mbio.00184-24 · Cited by 17
Metadata
- Authors
- Liao, Y., Chen, J., Brandt, B. W., Zhu, Y., Li, J., van Loveren, C., & Deng, D. M.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-09
- Volume
- 10
- Issue
- 4
- Pages
- e0122630
- ISSN
- 1932-6203
- PMC
- PMC4391945
- Cited by
- 58
- References
- 0
- Language
- en
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