Hypoxia Pretreatment of Bone Marrow Mesenchymal Stem Cells Facilitates Angiogenesis by Improving the Function of Endothelial Cells in Diabetic Rats with Lower Ischemia
Open accessAbstract
Endothelial dysfunction induced by unordered metabolism results in vascular reconstruction challenges in diabetic lower limb ischemia (DLLI). Mesenchymal stem cells (MSCs) are multipotent secretory cells that are suitable for clinical DLLI treatment, but their use has been hampered by poor survival after injection. Hypoxia can significantly enhance the capacity of MSCs to secrete angiogenic factors. We investigated transient hypoxia pretreatment of MSCs to facilitate revascularization in DLLI. Rat bone marrow MSCs (BM-MSCs) were cultured at different oxygen concentrations for varying time periods. The results indicated that transient pretreatment (5% O2, 48 h) not only increased the expression of VEGF-1α, ANG, HIF-1α and MMP-9 in BM-MSCs as assessed by real-time RT-PCR, but also increased the expression of Bcl-2 as determined by western blotting. The transplantation of pretreated BM-MSCs into rats with DLLI demonstrated accelerated vascular reconstruction when assayed by angiography and immunohistochemistry. CM-Dil-labeled tracer experiments indicated that the survival of BM-MSCs was significantly improved, with approximately 5% of the injected cells remaining alive at 14 days. The expression levels of VEGF-1α, MMP-9 and VEGF-R were significantly increased, and the expression of pAKT was up-regulated in ischemic muscle. Double immunofluorescence studies confirmed that the pretreated BM-MSCs promoted the proliferation and inhibited the apoptosis of endothelial cells. In vitro, pretreated BM-MSCs increased the migratory and tube forming capacity of endothelial cells (ECs). Hypoxia pretreatment of BM-MSCs significantly improved angiogenesis in response to tissue ischemia by ameliorating endothelial cell dysfunction and is a promising therapeutic treatment for DLLI.
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Upregulation of the VEGF gene was evident in all hypoxia cultures.
“Upregulation of the VEGF gene was evident in all hypoxia cultures, which is consistent with other studies [53–56].”
From Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells (2018) · cites this paper as [56]
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- Authors
- Liu, J., Hao, H., Xia, L., Ti, D., Huang, H., Dong, L., Tong, C., Hou, Q., Zhao, Y., Liu, H., Fu, X., & Han, W.
- Affiliations
- Chinese PLA General Hospital (CN)
- Corresponding author
- Fu, Xiaobing
- Han, Weidong
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-05-21
- Volume
- 10
- Issue
- 5
- Pages
- e0126715
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4440823
- OpenAlex
- W1506316383
- Cited by
- 101
- References
- 37
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 12 · 2023: 13 · 2022: 11 · 2021: 7 · 2020: 14 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 10 · 2015: 3
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (2012CB518105, 81121004, 81230041, 2013AA020105, 2012AA020502, 2012CB518103)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- bone marrow mesenchymal stem cells, angiogenesis, endothelial dysfunction, revascularization, HIF-1α, MMP-9, Bcl-2, cell survival after transplantation, Akt signaling, angiogenic factors
- MeSH terms
- Angiography, Animals, Hypoxia, Cell Survival, Cells, Cultured, Diabetes Mellitus, Experimental, Disease Models, Animal, Humans, Ischemia, Male, Neovascularization, Pathologic, Ultrasonography, Signal Transduction, Apoptosis, Lower Extremity, Vascular Endothelial Growth Factors, Endothelial Cells, Angiogenesis Inducing Agents, Mesenchymal Stem Cell Transplantation, Proto-Oncogene Proteins c-akt, Rats, Mesenchymal Stem Cells, Human Umbilical Vein Endothelial Cells
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