Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice
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Bacopa monnieri extract has been implicated in the recovery of memory impairments due to various neurological disorders in animal models and humans. However, the precise molecular mechanism of the role of CDRI-08, a well characterized fraction of Bacopa monnieri extract, in recovery of the diabetes mellitus-induced memory impairments is not known. Here, we demonstrate that DM2 mice treated orally with lower dose of CDRI-08 (50- or 100 mg/kg BW) is able to significantly enhance spatial memory in STZ-DM2 mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus. Treatment of DM2 mice with its higher dose (150 mg/kg BW or above) shows anti-diabetic effect in addition to its ability to recover the spatial memory impairment by reversing the DM2-induced elevated oxidative stress and decreased GluR2 subunit expression near to their values in normal and CDRI-08 treated control mice. Our results provide evidences towards molecular basis of the memory enhancing and anti diabetic role of the Bacopa monnieri extract in STZ-induced DM2 mice, which may have therapeutic implications.
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Bacopa alcoholic extract at doses of 20, 40 and 80 mg/kg improved escape latency in the Morris water maze test and prevented the reduction in cholinergic neuron density in the animal model of Alzheimer's disease induced by bilateral intracerebroventricular administration of AF64A.
“The effect of alcoholic extract of Bacopa has been evaluated at the dose of 20, 40 and 80 mg/kg on cognitive functions and neurodegeneration in the animal model of AD induced by bilateral intracerebroventricular administration of AF64A. They found that Bacopa improved the escape latency in the Morris water maze test and prevented the reduction in cholinergic neuron density [47,82].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [82]
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References 86 · Cited by 64
Research works printed but not linked: 2
- [24]Sivarajan V, Balachandran I. Ayurvedic drugs and their plant sources: Oxford and IBH Publishing; 1994.
- [32]Singh R, Singh L. Studies on the anti-anxiety effect of the medhya rasayana drug brahmi (Bacopa moniera Wettst), part I. J Res Ayur Siddha 1980; 1: 133. 1981;148.
- Authors
- Pandey, S. P., Singh, H. K., & Prasad, S.
- Affiliations
- Banaras Hindu University (IN)
- Corresponding author
- Prasad, S.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-07-10
- Volume
- 10
- Issue
- 7
- Pages
- e0131862
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4498885
- OpenAlex
- W817733125
- Cited by
- 64
- References
- 86
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 3
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Banaras Hindu University
- Board of Research in Nuclear Sciences (37/1389/09/EMR-II, 2009/37/55/3298)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Bacopa monnieri, type 2 diabetes, streptozotocin-induced diabetes, spatial memory, hippocampus, oxidative stress, AMPA receptors, GluR2 subunit, memory impairment, anti-diabetic effects, neuroprotection
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Drug Evaluation, Preclinical, Hypoglycemic Agents, Male, Malondialdehyde, Memory Disorders, Plant Extracts, Streptozocin, Gene Expression, Receptors, AMPA, Oxidative Stress, Maze Learning, Bacopa, Mice, CA3 Region, Hippocampal, Spatial Memory
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