Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses

Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

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The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

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Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

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Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

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The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity

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Mitochondria and cell signalling

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Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway

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Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

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Hepatic ischemia/reperfusion injury—a fresh look

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Liver ischemia/reperfusion injury: Processes in inflammatory networks—A review

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Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells

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Heme oxygenase-1 and anti-inflammatory M2 macrophages

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Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

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Donation After Circulatory Death

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Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

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Molecular Biology of Liver Ischemia/Reperfusion Injury: Established Mechanisms and Recent Advancements

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Toll-Like Receptor 9 Inhibition Confers Protection From Liver Ischemia–Reperfusion Injury

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Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

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Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion

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Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

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Molecular Mediators of Liver Ischemia and Reperfusion Injury: A Brief Review

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Hepatocyte-Specific High-Mobility Group Box 1 Deletion Worsens the Injury in Liver Ischemia/Reperfusion: A Role for Intracellular High-Mobility Group Box 1 in Cellular Protection

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Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury

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Hepatic Ischemia and Reperfusion Injury and Trauma: Current Concepts

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Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

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Cerebrospinal Fluid Mitochondrial DNA

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Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection—the good, bad and deadly

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Butyrate Protects Rat Liver against Total Hepatic Ischemia Reperfusion Injury with Bowel Congestion

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Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury

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Release of S100B Differs During Ischemia and Reperfusion of the Liver, the Gut, and the Kidney in Rats

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Impact of Age Older Than 60 Years in Living Donor Liver Transplantation

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Microparticles Mediate Hepatic Ischemia-Reperfusion Injury and Are the Targets of Diannexin (ASP8597)

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Mitochondrial-derived N-formyl peptides: Novel links between trauma, vascular collapse and sepsis

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Antioxidant defense in hepatic ischemia-reperfusion injury is regulated by damage-associated molecular pattern signal molecules

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Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation

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Induction of heme oxygenase-1 protects mouse liver from apoptotic ischemia/reperfusion injury

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Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion

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Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway

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Erratum: Corrigendum: Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

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Marked Difference in Tumor Necrosis Factor-α Expression in Warm Ischemia– and Cold Ischemia–Reperfusion of the Rat Liver

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BH3-only proteins contribute to steatotic liver ischemia–reperfusion injury

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Mitochondria as a therapeutic target for common pathologies

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Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

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Origin and Consequences of Necroinflammation

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The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

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Transplantation and Damage-Associated Molecular Patterns (DAMPs)

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Mitochondrial DNA in liver inflammation and oxidative stress

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Role of Immuno-Inflammatory Signals in Liver Ischemia-Reperfusion Injury

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ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders

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cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING

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The sensing of mitochondrial DAMPs by non-immune cells

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Mitochondrial dysfunction: A promising therapeutic target for liver diseases

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Mitochondria as Therapeutic Targets in Transplantation

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Danger signals in regulating the immune response to solid organ transplantation

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Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

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The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis

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High Tidal Volume Induces Mitochondria Damage and Releases Mitochondrial DNA to Aggravate the Ventilator-Induced Lung Injury

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Oxidative Stress—A Key Player in the Course of Alcohol-Related Liver Disease

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Cryptides: latent peptides everywhere

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Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction

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A Unifying Hypothesis Linking Hepatic Adaptations for Ethanol Metabolism to the Proinflammatory and Profibrotic Events of Alcoholic Liver Disease

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Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

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Mitochondria‐derived damage‐associated molecular patterns and inflammation in the ischemic‐reperfused heart

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Intravital Imaging of Neutrophil Recruitment Reveals the Efficacy of FPR1 Blockade in Hepatic Ischemia-Reperfusion Injury

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Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis

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Mitochondrial DNA copy number is associated with all‐cause mortality and cardiovascular events in patients with peripheral arterial disease

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The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness

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The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms

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Elevated Levels of Plasma Mitochondrial DNA Are Associated with Clinical Outcome in Intra-Abdominal Infections Caused by Severe Trauma

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The Role of Mitochondrial DNA in the Development of Ischemia Reperfusion Injury

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P2Y2R activation by ATP induces oxLDL-mediated inflammasome activation through modulation of mitochondrial damage in human endothelial cells

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Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review

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The Critical Role of Bioenergetics in Donor Cardiac Allograft Preservation

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Targeting NF-κB in Hepatic Ischemia–Reperfusion Alleviation: from Signaling Networks to Therapeutic Targeting

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Current approaches used in treating COVID-19 from a molecular mechanisms and immune response perspective

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Steatotic Donor Transplant Livers: Preservation Strategies to Mitigate against Ischaemia-Reperfusion Injury

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Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

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Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH)

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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole

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Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis?

Li, X., Zhang, Q., Wang, Z., Zhuang, Q., & Zhao, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.802251 · Cited by 21 · see citing works

Deciphering the mitochondria-inflammation axis: Insights and therapeutic strategies for heart failure

Zuo, B., Xiu, F., Xu, D., Zhao, L., Zhang, B., & Li, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112697 · Cited by 18 · see citing works

Mitochondrial Targeting Therapy Role in Liver Transplant Preservation Lines: Mechanism and Therapeutic Strategies

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Mitochondrial DNA levels in perfusate and bile during ex vivo normothermic machine correspond with donor liver quality

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Cross‐presentation of dead‐cell‐associated antigens by DNGR‐1 + dendritic cells contributes to chronic allograft rejection in mice

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Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages

Marutani, T., Nishino, K., Miyaji, T., Kamada, K., Ohura, K., Kiso, Y., & Mukai, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084084 · Cited by 10 · see citing works

When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness

Torp, M., Stensløkken, K., & Vaage, J. (2024) · Journal of Intensive Care Medicine · doi:10.1177/08850666241237715 · Cited by 10 · see citing works

Colonic anastomosis can be protected from ischemia reperfusion injury with intra-peritoneal Montelukast treatment

Sayın, T., Cimen, S., Cimen, S., Bostancı, T., Akbaba, S., Yıldırım, Z., & Ersoy, P. E. (2019) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2019.01.022 · Cited by 9 · see citing works

ECP-induced Apoptosis: How Noninflammatory Cell Death Counterbalances Ischemia/Reperfusion Injury

Stępień, J., & Eggenhofer, E. (2025) · Transplantation Direct · doi:10.1097/txd.0000000000001816 · Cited by 8 · see citing works

Recovery and immune function after low pressure pneumoperitoneum during robot‐assisted radical prostatectomy: a randomised controlled trial

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Cyclophilin D (PPIF) and MPTP in hepatic ischemia-reperfusion injury: insights into mechanisms

Liu, J., Wu, C., Lin, Z., Ma, M., Ma, W., Yu, X., Wang, W., & Zeng, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1575242 · Cited by 7 · see citing works

Macrophages in xenotransplantation

Kim, J. Y. (2019) · Korean Journal of Transplantation · doi:10.4285/jkstn.2019.33.4.74 · Cited by 7 · see citing works

Neutrophil-T cell cross talk in noninfectious liver diseases

Gromová, B., Kupčová, V., Longhi, M. S., & Gardlík, R. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00192.2025 · Cited by 6 · see citing works

Assessment of mitochondrial viability under calcium Stress: Insights for mitochondrial transplantation

Toosky, M., & Kheradvar, A. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102098 · Cited by 5 · see citing works

Innate Immune Cells during Machine Perfusion of Liver Grafts—The Janus Face of Hepatic Macrophages

Pollmann, N. S., Pascher, A., & Becker, F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226669 · Cited by 5 · see citing works

Prologue: About DAMPs, PAMPs, and MAMPs

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Effects of Plateau Air Quality and Low Oxygen Content on Platelet mtDNA Methylation and High Altitude Pulmonary Edema

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Deep neuromuscular blockade in adults undergoing an abdominal laparoscopic procedure

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Migrating Progenitor Cells Derived From Injured Cartilage Surface Respond to Damage-Associated Molecular Patterns

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Sex Difference in Plasma Deoxyribonuclease Activity in Rats

Janovičová, Ľ., Gromová, B., Drobná, D., Konečná, D., Renczés, E., Borbélyová, V., Hodosy, J., & Celec, P. (2021) · Physiological Research · doi:10.33549/physiolres.934766 · Cited by 3 · see citing works

Mitochondrial DAMPs produce inflammatory hyperalgesia via stimulator of interferon genes (STING) activation in DRG neurons

Amino, H., Higashi, A., Yamakita, S., Horii, Y., & Amaya, F. (2026) · Molecular Pain · doi:10.1177/17448069261435322 · Cited by 2 · see citing works

Mitochondrial DNA regulation of hepatic ischemia-reperfusion injury and intervention strategies

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Damage-associated molecular patterns in hepatic ischemia–reperfusion injury: spatiotemporal signatures, biomarker potential, and clinical translation

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Aldehydes, mitophagy, and the pathogenesis of alcohol-associated and metabolic dysfunction-associated steatohepatitis

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Circulating Donor Mitochondrial DNA: Tales the Dead May Tell

Menon, M. C., & Banu, K. (2019) · Transplantation · doi:10.1097/tp.0000000000002597 · Cited by 2 · see citing works

Organ Preservation, Ischemia Reperfusion Injury, and Nanotherapeutics in Transplantation

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Potential of African plants and their derived phytochemicals against hepatocellular carcinoma

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Metabolic and inflammatory aspects of cardiothoracic surgical interventions

Schipper, D. A. (2021) · EUR Research Repository (Erasmus University Rotterdam)

Sex Difference in Plasma Deoxyribonuclease Activity in Rats

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Toward Equitable Heart Transplant Outcomes

Valantine, H. A., & Khush, K. K. (2024) · JACC Heart Failure · doi:10.1016/j.jchf.2024.04.024

Detection of Danger-Associated Molecular Patterns in Kidney Preservation Fluid as Predictors of Delayed Graft Function after TransplantationPreprint

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General principles of organ preservation in liver transplantation

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Analysis of Determinants and Development of a Predictive Model for Postoperative Cognitive Dysfunction in Patients Undergoing Hepatectomy

Li, Y. C., Xu, J., Xue, B., Cao, J., Yang, H., & Li, X. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15093508

PANoptosis in hepatic ischemia–reperfusion injury: An integrated cell death network linking inflammation and hepatocellular damage

Wang, J., Guo, S., Jin, J., Wang, X., Su, Y., Liu, Y., & Zhang, H. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156661

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Mitochondrial Damage-Associated Molecular Patterns (MTDs) Released from Hepatic Ischemia Reperfusion Induce Inflammatory Response

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Mitochondrial DAMPs: Novel Markers for Hepatic Ischemia Reperfusion Injury.

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Elevated Levels of Circulating Oxidized Mitochondrial DNA Contribute to the Development of Ischemia Reperfusion Injury Following Liver Transplantation

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EXTRACELLULAR MITOCHONDRIA RELEASED FROM LIVER ISCHEMIA REPERFUSION INJURY ACT AS ALARMINS TO EVOKE INNATE IMMUNE SYSTEM AND TRIGGER INFLAMMATION

Hu, Q. (2020) · DalSpace (Dalhousie University)