The Mediating Role of Mental Adjustment in the Relationship between Perceived Stress and Depressive Symptoms in Hematological Cancer Patients: A Cross-Sectional Study
Open accessAbstract
BACKGROUND: Depression is a particularly common psychological disorder that affects cancer patients. Diagnosed with hematological malignancies constitute a serious unpredictable and uncontrollable medical stress situation and patients are susceptible to suffer from depressive symptoms. The aims of the study were to explore the correlation between perceived stress and depressive symptoms in patients with hematological malignancies, and assess the mediating role of mental adjustment between these variables. METHODS: A single center, cross-sectional study was performed by convenience sampling between July 2013 and April 2014 in a hospital of China. The Center for Epidemiologic Studies Depression Scale, Perceived Stress Scale, and Mini-Mental Adjustment Scale, as well as questions about demographic and clinical factors was distributed to 300 hematological cancer patients. Completed questionnaires were received from 227 inpatients. RESULTS: The results showed that perceived stress was positively correlated with depressive symptoms. The mental adjustment significantly mediated the relationship between perceived stress and depressive symptoms. CONCLUSIONS: Among hematological cancer patients perceived stress may be a risk factor for depressive symptoms, whereas positive coping style might be protective against depressive symptoms. Results showed that medical managers could support the development of mental adjustment in the patients to alleviate psychological disorders.
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ACT promotes active coping oriented toward one's values, a factor related to better adjustment to illness, treatment adherence, quality of life, and self-efficacy perception.
“ACT promueve un afrontamiento activo y orientado hacia los propios valores, factor que se ha visto relacionado con mejor ajuste a la enfermedad, adherencia al tratamiento, calidad de vida y percepción de autoeficacia (62,63) .”
From AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso. (2025) · cites this paper as [63]
The Discussion links positive coping and attitude with better psychological adjustment and fewer depressive symptoms in hematological cancer patients. The Introduction also discusses a relationship among adjustment style, self-efficacy, and well-being. Neither passage establishes that ACT promotes values-oriented coping or that such coping improves treatment adherence or quality of life. (LLM, conf=0.88)
Experimental — accuracy not yet measuredACT promotes active coping oriented toward one's values, a factor related to better adjustment to illness, treatment adherence, quality of life, and self-efficacy perception.
“ACT promueve un afrontamiento activo y orientado hacia los propios valores, factor que se ha visto relacionado con mejor ajuste a la enfermedad, adherencia al tratamiento, calidad de vida y percepción de autoeficacia (62,63) .”
From AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso. (2025) · cites this paper as [62]
The Discussion (page unavailable) links positive coping and attitude to psychological adjustment and fewer depressive symptoms in cancer patients. The Introduction (page unavailable) discusses mental adjustment in relation to self-efficacy and well-being. The paper does not establish that ACT promotes values-oriented coping or that such coping improves treatment adherence or quality of life. (LLM, conf=0.87)
Experimental — accuracy not yet measured
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- Authors
- Li, Y., Yang, Y., Zhang, R., Yao, K., & Liu, Z.
- Affiliations
- Sheng Jing Hospital (CN)
- Corresponding author
- Li, Yingchun
- Yang, Ying
- Zhang, Rong
- Yao, Kun
- Liu, Zhuogang
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-11-20
- Volume
- 10
- Issue
- 11
- Pages
- e0142913
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4666411
- OpenAlex
- W2177014946
- Cited by
- 30
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
- Social Sciences › Sociology and Political Science › Family Support in Illness
- Keywords
- psychological adjustment, perceived stress, depressive symptoms, hematologic malignancies, cancer patients, coping styles, mediation, psychological distress
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Depression, Emotions, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Stress, Psychological, Hematologic Neoplasms
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