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Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study
Open accessAbstract
Despite being quite frequent and having serious implications in terms of symptomatology and fertility, data on incidence and prevalence of endometriosis and adenomyosis following gold standard definitions are dramatically lacking. The average time from onset of symptoms to diagnosis in industrialized countries still ranges from five to ten years. Using the regional centralized data linkage system, we calculated incidence and prevalence of endometriosis and adenomyosis in the female population of Friuli Venezia Giulia region, Italy, for the years 2011-2013. Cases were defined as new diagnoses from hospital discharge records, following procedures allowing direct visualization for endometriosis and hysterectomy for adenomyosis, with or without histological confirmation. Diagnoses were considered "new" after verifying women had not been diagnosed in the previous ten years. Incidence of endometriosis and adenomyosis in women aged 15-50 years is 0.14%. Prevalence, estimated from incidence, is 2.00%. Adenomyosis, representing 28% of all diagnoses, becomes increasingly prevalent after the age of 50 years. Our results shows how the study of both endometriosis and adenomyosis should not be limited to women of premenopausal age. Further efforts are needed to sensitize women and health professional, and to find new data linkage possibilities to identify undiagnosed cases.
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“In a rare population-based study, the estimated prevalence of adenomyosis in Northeast Italy is reported to be 0.18%, much lower than that of endometriosis (1.14%) [17].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [17]
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“The age-specific incidence of adenomyosis is very different from that of endometriosis, reaching its peak at the age interval of 46–50 years [17].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [17]
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Research works printed but not linked: 1
- 2012, Disposizioni per la tutela delle donne affette da endometriosi, Bollettino Ufficiale Regionale Friuli Venezia Giulia, 42, 11
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Clinical diagnosis of endometriosis: a call to action
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Metadata
- Authors
- Morassutto, C., Monasta, L., Ricci, G., Barbone, F., & Ronfani, L.
- Affiliations
- IRCCS Materno Infantile Burlo Garofolo (IT)
- University of Trieste (IT)
- University of Udine (IT)
- Corresponding author
- Monasta, Lorenzo
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-04-21
- Volume
- 11
- Issue
- 4
- Pages
- e0154227
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4839734
- OpenAlex
- W2341654050
- Cited by
- 157
- References
- 29
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 20 · 2022: 24 · 2021: 19 · 2020: 31 · 2019: 14 · 2018: 8 · 2017: 5 · 2016: 3
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, cc-by)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion, cc-by)
- Institutional Research Information System (University of Udine) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Regional Health Authority of Friuli Venezia Giulia (Dec. 979/Pren. 16/10/2014)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, adenomyosis, incidence, prevalence, data linkage, hospital discharge data, hysterectomy, delayed diagnosis, women's health, Friuli Venezia Giulia
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Endometriosis, Female, Humans, Italy, Middle Aged, Registries, Incidence, Prevalence, Information Storage and Retrieval, Young Adult, Adenomyosis
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