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CaMKII-mediated CREB phosphorylation is involved in Ca2+-induced BDNF mRNA transcription and neurite outgrowth promoted by electrical stimulation

Yan, Xiaodong, Liu, Juanfang, Ye, Zhengxu, Huang, Jinghui, He, Fei, Xiao, Wei, Hu, Xueyu, Luo, Zhuojing·2016·PLOS ONE
DOI 10.1371/journal.pone.0162784PMC PMC5017744
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  • Ca2+ activates CAMKs, which phosphorylate CREB (pCREB), which in turn activates BDNF transcription by binding to a cAMP-response element within the gene.

    “Ca2+ acts by activating CAMKs which trigger phosphorylation of CREB (pCREB), which in turn activates BDNF transcription by binding to a cAMP-response element within the gene (Su et al., 2016; Yan et al., 2016).”

    From miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A (2020) · cites this paper as Yan et al., 2016

  • CAMK2A phosphorylates CREB, a transcription factor that mediates BDNF transcription.

    “A critical function of CAMK2A is the phosphorylation of CREB, a transcription factor that mediates the transcription of BDNF (Yan et al., 2016).”

    From miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A (2020) · cites this paper as Yan et al., 2016

  • CAMK2A-mediated pCREB is involved in Ca2+ induced expression of BDNF which is imperative for neuronal signaling and neurite outgrowth.

    “It has been shown that CAMK2A-mediated pCREB is involved in Ca2+ induced expression of BDNF which is imperative for neuronal signaling and neurite outgrowth (Yan et al., 2016).”

    From miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A (2020) · cites this paper as Yan et al., 2016

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Sorted by citations

Authors
Yan, X., Liu, J., Ye, Z., Huang, J., He, F., Xiao, W., Hu, X., & Luo, Z.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2016-09-09
Volume
11
Issue
9
Pages
e0162784
ISSN
1932-6203
DOI
10.1371/journal.pone.0162784
PMC
PMC5017744
Cited by
159
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Natural Science Foundation of China (30770571, 81401001, and 81101352)

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