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Cited by 567Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Calmodulin-kinases: modulators of neuronal development and plasticity.

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Wayman, Gary A., Lee, Yong-Seok, Tokumitsu, Hiroshi, Silva, Alcino, Soderling, Thomas R.·2008·Neuron
DOI 10.1016/j.neuron.2008.08.021PMC PMC2664743
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Abstract

In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca(2+)/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.

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  • This rephosphorylation was blocked by KT5720 (1 μM), a PKA inhibitor, but not by KN-93 (10 μM) and PD98059 (25 μM).

    “This rephosphorylation was blocked by KT5720 (1 µM), a PKA inhibitor, but not by KN-93 (10 µM) and PD98059 (25 µM), which inhibit CaM kinases [41] and MEK, respectively (Figure 3F).”

    From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [41]

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Cited by

Sorted by citations

Authors
Wayman, G. A., Lee, Y.-S., Tokumitsu, H., Silva, A., & Soderling, T. R.
Affiliations
  • Oregon Health & Science University (US)
  • University of California, Los Angeles (US)
  • Kagawa University (JP)
Corresponding author
Soderling, Thomas R.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2008-09
Volume
59
Issue
6
Pages
914-931
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.08.021
PMC
PMC2664743
OpenAlex
W2024035512
Cited by
567
References
15
Citations by year
2026: 22 · 2025: 22 · 2024: 20 · 2023: 19 · 2022: 19 · 2021: 25 · 2020: 27 · 2019: 32 · 2018: 32 · 2017: 21 · 2016: 33 · 2015: 25 · 2014: 32 · 2013: 43 · 2012: 46
FWCI
4.28
Type
journal article
Language
en
Update notices
erratum (2009-11-25)
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG013622)
  • National Institute of General Medical Sciences (R01GM041292)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
calcium/calmodulin-dependent protein kinase, CaMKII, CaMKI, CaMKIV, CaMKK, neuronal development, synaptic plasticity, learning and memory, calcium signaling, protein phosphorylation, gene transcription, signal transduction, synaptic development, behavior
MeSH terms
Animals, Cell Differentiation, Humans, Neuronal Plasticity, Neurons, Structure-Activity Relationship, Second Messenger Systems, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, Calcium Signaling

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