The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

Sickmier, E. Allen; Kurzeja, Robert J. M.; Michelsen, Klaus; Vazir, Mukta; Yang, Evelyn; Tasker, Andrew S.

doi:10.1371/journal.pone.0163366

The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

Panitumumab and cetuximab target the epidermal growth factor receptor for the treatment of metastatic colorectal cancer. These therapies provide a significant survival benefit to patients with metastatic colorectal cancer with wild-type RAS. A single point mutation in the ectodomain of EGFR (S468…