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Cited by 23Malaria Research and ControlInsect Pest Control StrategiesMosquito-borne diseases and control

Remote Effect of Insecticide-Treated Nets and the Personal Protection against Malaria Mosquito Bites

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Moiroux, Nicolas, Chandre, Fabrice, Hougard, Jean-Marc, Corbel, Vincent, Pennetier, Cédric·2017·PLOS ONE
DOI 10.1371/journal.pone.0170732PMC PMC5271322

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Abstract

Experimental huts are part of the WHO process for testing and evaluation of Insecticide Treated Nets (ITN) in semi-field conditions. Experimental Hut Trials (EHTs) mostly focus on two main indicators (i.e., mortality and blood feeding reduction) that serve as efficacy criteria to obtain WHO interim recommendation. However, several other outputs that rely on counts of vectors collected in the huts are neglected although they can give useful information about vectors' behavior and personal protection provided by ITNs. In particular, EHTs allow to measure the deterrent effect and personal protection of ITNs. To provide a better assessment of ITNs efficacy, we performed a retrospective analysis of the deterrence and the personal protection against malaria transmission for 12 unwashed and 13 washed ITNs evaluated through EHTs conducted in West Africa. A significant deterrent effect was shown for six of the 12 unwashed ITNs tested. When washed 20 times, only three ITNs had significant deterrent effect (Rate Ratios (RR)<1; p<0.05) and three showed an apparent "attractiveness" (RR>1; p<0.01). When compared to the untreated net, all unwashed ITNs showed lower number of blood-fed Anopheles indicating a significant personal protection (RR<1, p<0.05). However, when washed 20 times, three ITNs that were found to be attractive did not significantly reduce human-vector contact (p>0.05). Current WHO efficacy criteria do not sufficiently take into account the deterrence effect of ITNs. Moreover, the deterrence variability is rarely discussed in EHT's reports. Our findings highlighted the long-range effect (deterrent or attractive) of ITNs that may have significant consequences for personal/community protection against malaria transmission. Indicators measuring the deterrence should be further considered for the evaluation of ITNs.

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  • A recent study highlighted the long-range effect (deterrent or attractive) of ITNs that may have significant consequences for personal and community protection against malaria transmission.

    “As an example, a recent study highlighted the long-range effect (deterrent or attractive) of ITNs that may have significant consequences for personal and community protection against malaria transmission [53].”

    From Mapping insecticide resistance in Anopheles gambiae (s.l.) from Côte d'Ivoire (2018) · cites this paper as [53]

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  1. [9]Fanello C, Kolaczinski JH, Conway DJ, Carnevale P, Curtis CF. The kdr pyrethroid resistance gene in Anopheles gambiae: tests of non-pyrethroid insecticides and a new detection method for the gene. Parassitologia. 1999 9; 41(1–3): 323– 6. 10697877
  2. [10]Okumu FO, Mbeyela E, Lingamba G, Moore J, Ntamatungiro AJ, Kavishe DR, et al Comparative field evaluation of combinations of long-lasting insecticide treated nets and indoor residual spraying, relative to either method alone, for malaria prevention in an area where the main vector is Anopheles arabiensis. Parasit Vectors. 2013; 6: 46 10.1186/1756-3305-6-46 23433393 PMC3606331 · DOI
  3. [11]Ngufor C, N’Guessan R, Boko P, Odjo A, Vigninou E, Asidi A, et al Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin. Malar J. 2011; 10: 343 10.1186/1475-2875-10-343 22087506 PMC3229591 · DOI
  4. [12]Malima RC, Oxborough RM, Tungu PK, Maxwell C, Lyimo I, Mwingira V, et al Behavioural and insecticidal effects of organophosphate-, carbamate- and pyrethroid-treated mosquito nets against African malaria vectors. Med Vet Entomol. 2009 12; 23(4): 317– 25. 10.1111/j.1365-2915.2009.00837.x 19941597 · DOI
  5. [13]Malima RC, Magesa SM, Tungu PK, Mwingira V, Magogo FS, Sudi W, et al An experimental hut evaluation of Olyset nets against anopheline mosquitoes after seven years use in Tanzanian villages. Malar J. 2008; 7: 38 10.1186/1475-2875-7-38 18307802 PMC2267806 · DOI
  6. [14]Ngufor C, N’Guessan R, Fagbohoun J, Todjinou D, Odjo A, Malone D, et al Efficacy of the Olyset Duo net against insecticide-resistant mosquito vectors of malaria. Sci Transl Med. 2016 9 14; 8(356): 356ra121 10.1126/scitranslmed.aad3270 27629488 · DOI
  7. [25]Djegbe I, Boussari O, Sidick A, Martin T, Ranson H, Chandre F, et al Dynamics of insecticide resistance in malaria vectors in Benin: first evidence of the presence of L1014S kdr mutation in Anopheles gambiae from West Africa. Malar J. 2011; 10(1): 261. 21910856 PMC3179749
  8. [28]Takken W. Do insecticide-treated bednets have an effect on malaria vectors? Trop Med Int Health. 2002; 7(12): 1022– 30. 12460393
  9. [29]Lindsay SW, Adiamah JH, Miller JE, Armstrong JR. Pyrethroid-treated bednet effects on mosquitoes of the Anopheles gambiae complex in The Gambia. Med Vet Entomol. 1991 10; 5(4): 477– 83. 1773125
  10. [30]Bomann W. How safe are pyrethroid-treated mosquito nets? An evaluation based on the example of Solfac EW 050. Public Health. 1995; 12: 30– 5.
  11. [31]Barlow SM, Sullivan FM, Lines J. Risk assessment of the use of deltamethrin on bednets for the prevention of malaria. Food Chem Toxicol. 2001 mai; 39(5): 407– 22. 11313107
  12. [33]Angioy AM, Desogus A, Barbarossa IT, Anderson P, Hansson BS. Extreme Sensitivity in an Olfactory System. Chem Senses. 2003 5 1; 28(4): 279– 84. 12771014
  13. [34]Baker TC, Roelofs WL. Initiation and Termination of Oriental Fruit Moth Male Response to Pheromone Concentrations in the Field. Environ Entomol. 1981 avril; 10(2): 211.
  14. [35]Clements AN. The Biology of Mosquitoes Volume 2: Sensory, Reception, and Behaviour. First edition Wallingford u.a.: CABI; 1999 752 p.
  15. [36]Pennetier C, Bouraima A, Chandre F, Piameu M, Etang J, Rossignol M, et al Efficacy of Olyset® Plus, a New Long-Lasting Insecticidal Net Incorporating Permethrin and Piperonil-Butoxide against Multi-Resistant Malaria Vectors. PloS One. 2013; 8(10): e75134 10.1371/journal.pone.0075134 24116029 PMC3792972 · DOI
  16. [37]Logan JG, Stanczyk NM, Hassanali A, Kemei J, Santana AE, Ribeiro KA, et al Arm-in-cage testing of natural human-derived mosquito repellents. Malar J. 2010; 9: 239 10.1186/1475-2875-9-239 20727149 PMC2931528 · DOI
  17. [38]Guha L, Seenivasagan T, Iqbal ST, Agrawal OP, Parashar BD. Behavioral and electrophysiological responses of Aedes albopictus to certain acids and alcohols present in human skin emanations. Parasitol Res. 2014 7 23; 113(10): 3781– 7. 10.1007/s00436-014-4044-0 25049052 · DOI
  18. [39]Seenivasagan T, Guha L, Parashar BD, Agrawal OP, Sukumaran D. Olfaction in Asian tiger mosquito Aedes albopictus: flight orientation response to certain saturated carboxylic acids in human skin emanations. Parasitol Res. 2014 3 12; 113(5): 1927– 32. 10.1007/s00436-014-3840-x 24619069 · DOI
  19. [40]Mutuku FM, Khambira M, Bisanzio D, Mungai P, Mwanzo I, Muchiri EM, et al Physical condition and maintenance of mosquito bed nets in Kwale County, coastal Kenya. Malar J. 2013; 12(1): 46. 23374429 PMC3572415
  20. [41]Erlanger TE, Enayati AA, Hemingway J, Mshinda H, Tami A, Lengeler C. Field issues related to effectiveness of insecticide-treated nets in Tanzania. Med Vet Entomol. 2004 6; 18(2): 153– 60. 10.1111/j.0269-283X.2004.00491.x 15189240 · DOI
  21. [42]Lindblade KA, Dotson E, Hawley WA, Bayoh N, Williamson J, Mount D, et al Evaluation of long-lasting insecticidal nets after 2 years of household use. Trop Med Int Health. 2005 11; 10(11): 1141– 50. 10.1111/j.1365-3156.2005.01501.x 16262739 · DOI · Paper page
  22. [43]Porciani A, Diop MM, Moiroux N, Kadoke-Lambi T, Cohuet A, Chandre F, et al A pyrethroid-treated bed net increases host attractiveness for Anopheles gambiae s.s carrying the kdr allele in a dual choice olfactometer. bioRxiv [Internet]. 2016 9 26;
  23. [44]Guyatt HL, Snow RW. The cost of not treating bednets. Trends Parasitol. 2002 1; 18(1): 12– 6. 11850008
  24. [45]Killeen GF, Smith TA, Ferguson HM, Mshinda H, Abdulla S, Lengeler C, et al Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets. PLoS Med. 2007 7; 4(7): e229 10.1371/journal.pmed.0040229 17608562 PMC1904465 · DOI
  25. [46]Killeen GF, Chitnis N, Moore SJ, Okumu FO. Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? Malar J. 2011; 10: 207 10.1186/1475-2875-10-207 21798023 PMC3199905 · DOI
  26. [47]Okumu FO, Kiware SS, Moore SJ, Killeen GF. Mathematical evaluation of community level impact of combining bed nets and indoor residual spraying upon malaria transmission in areas where the main vectors are Anopheles arabiensis mosquitoes. Parasit Vectors. 2013; 6: 17 10.1186/1756-3305-6-17 23324456 PMC3564902 · DOI
  27. [48]Churcher TS, Lissenden N, Griffin JT, Worrall E, Ranson H. The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa. eLife. 2016 8 22; 5. PMC5025277 27547988

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Authors
Moiroux, N., Chandre, F., Hougard, J.-M., Corbel, V., & Pennetier, C.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Moiroux, Nicolas
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2017-01-27
Volume
12
Issue
1
Pages
e0170732
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0170732
PMC
PMC5271322
OpenAlex
W2952511083
Cited by
23
References
5
Citations by year
2025: 6 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1
FWCI
1.03
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Institut de Recherche pour le Développement (FR)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Keywords
insecticide-treated nets, experimental hut trials, Anopheles, net washing, human-vector contact, malaria transmission, vector behavior
MeSH terms
Africa, Western, Animals, Anopheles, Ectoparasitic Infestations, Humans, Insect Bites and Stings, Insect Vectors, Insecticides, Malaria, Mosquito Control, Retrospective Studies, Insecticide-Treated Bednets

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