Cited by 117Malaria Research and ControlInsect Resistance and GeneticsInsect Pest Control Strategies

Field efficacy of a new mosaic long-lasting mosquito net (PermaNet® 3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa

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Corbel, Vincent, Chabi, Joseph, Dabiré, Roch K, Etang, Josiane, Nwane, Philippe, Pigeon, Olivier, Akogbeto, Martin, Hougard, Jean-Marc·2010·Malaria Journal

Abstract

BACKGROUND: Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet 3.0, against wild pyrethroid-resistant Anopheles gambiae s.l. in West and Central Africa. METHODS: A multi centre experimental hut trial was conducted in Malanville (Benin), Vallée du Kou (Burkina Faso) and Pitoa (Cameroon) to investigate the exophily, blood feeding inhibition and mortality induced by PermaNet 3.0 (i.e. a mosaic net containing piperonyl butoxide and deltamethrin on the roof) comparatively to the WHO recommended PermaNet 2.0 (unwashed and washed 20-times) and a conventionally deltamethrin-treated net (CTN). RESULTS: The personal protection and insecticidal activity of PermaNet 3.0 and PermaNet 2.0 were excellent (>80%) in the "pyrethroid-tolerant" area of Malanville. In the pyrethroid-resistance areas of Pitoa (metabolic resistance) and Vallée du Kou (presence of the L1014F kdr mutation), PermaNet 3.0 showed equal or better performances than PermaNet 2.0. It should be noted however that the deltamethrin content on PermaNet 3.0 was up to twice higher than that of PermaNet 2.0. Significant reduction of efficacy of both LLIN was noted after 20 washes although PermaNet 3.0 still fulfilled the WHO requirement for LLIN. CONCLUSION: The use of combination nets for malaria control offers promising prospects. However, further investigations are needed to demonstrate the benefits of using PermaNet 3.0 for the control of pyrethroid resistant mosquito populations in Africa.

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  • New LLINs treated with a synergist such as piperonyl butoxide and pyrethroids insecticide have shown promising results against wild free-flying multi-resistant An. gambiae (s.s.) in experimental huts.

    “Some of these have shown promising results against wild free-flying multi-resistant An. gambiae (s.s.) in experimental huts [34, 43–45].”

    From Mapping insecticide resistance in Anopheles gambiae (s.l.) from Côte d'Ivoire (2018) · cites this paper as [44]

    The Background describes PermaNet® 3.0 as a net combining deltamethrin with the synergist piperonyl butoxide. The Results report promising experimental-hut performance against free-flying, pyrethroid-resistant An. gambiae s.s., particularly in Vallée du Kou. They do not establish that those An. gambiae s.s. populations were multi-resistant; the reported resistance there is primarily associated with the kdr mutation. (LLM, conf=0.84)

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Authors
Corbel, V., Chabi, J., Dabiré, R. K., Etang, J., Nwane, P., Pigeon, O., Akogbeto, M., & Hougard, J.-M.
Affiliations
  • Institut de Recherche pour le Développement (BJ)
  • Centre Muraz (BF)
  • Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (CM)
  • Walloon Agricultural Research Centre (BE)
  • Institut de Recherche pour le Développement (SN)
Corresponding author
Corbel, Vincent
Venue
Malaria Journal
Published
2010-04-27
Volume
9
Issue
1
Pages
113-113
ISSN
1475-2875 (ISSN-L)
OpenAlex
W2134258056
Cited by
116
References
60
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 15 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 9
FWCI
9.54
Type
journal article
Language
en
Open access
Locations
  • Malaria Journal (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Keywords
PermaNet 3.0, long-lasting insecticidal nets, pyrethroid resistance, malaria vectors, Anopheles gambiae s.l., deltamethrin, piperonyl butoxide, metabolic resistance, exophily, blood-feeding inhibition, insecticide-treated nets, malaria vector control
MeSH terms
Animals, Anopheles, Benin, Burkina Faso, Cameroon, Feeding Behavior, Humans, Insecticide Resistance, Insecticides, Laundering, Malaria, Mosquito Control, Pyrethrins, Insecticide-Treated Bednets

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