Cited by 28

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Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology

Idkowiak-Baldys, Jolanta, Santhanam, Uma, Buchanan, Sean M., Pfaff, Kathleen Lindahl, Rubin, Lee L., Lyga, John·2019·PLOS ONE

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Crossref · 10.1371/journal.pone.0218035

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  • Restoring various serum proteins back into the blood will become a major target to restore youthful function into aged tissues, and beneficial proteins with rejuvenation properties include IGF2, GHRH, GnRH, and GDF11.

    “Restoring various serum proteins back into the blood will become a major target to restore youthful function back into aged tissues, and there are many beneficial proteins that hold rejuvenation properties such as insulin growth factor two (IGF2), 60 , 61 growth hormone releasing hormone ((GHRH), 62 gonadotropin releasing hormone GnRH), 63 and growth differentiation factor 11 (GDF11). 64 , 65”

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Research works printed but not linked: 19

  1. T Poggioli, 2016, Circulating Growth Differentiation Factor 11/8 Levels Decline With Age, Circ Res, 118, 29, 10.1161/CIRCRESAHA.115.307521 · DOI
  2. Y Zhang, 2015, Growth differentiation factor 11 is a protective factor for osteoblastogenesis by targeting PPARgamma, Gene, 557, 209, 10.1016/j.gene.2014.12.039 · DOI
  3. W Zhang, 2018, GDF11 Rejuvenates Cerebrovascular Structure and Function in an Animal Model of Alzheimer's Disease, J Alzheimers Dis, 62, 807, 10.3233/JAD-170474 · DOI
  4. Y Zhang, 2016, GDF11 improves tubular regeneration after acute kidney injury in elderly mice, Sci Rep, 6, 34624, 10.1038/srep34624 · DOI
  5. KA Olson, 2015, Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts, Eur Heart J, 36, 3426, 10.1093/eurheartj/ehv385 · DOI
  6. MA Egerman, 2015, GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration, Cell Metab, 22, 164, 10.1016/j.cmet.2015.05.010 · DOI · Paper page
  7. DJ Glass, 2016, Elevated GDF11 Is a Risk Factor for Age-Related Frailty and Disease in Humans, Cell Metab, 24, 7, 10.1016/j.cmet.2016.06.017 · DOI
  8. BD Rodgers, 2015, Reduced Circulating GDF11 Is Unlikely Responsible for Age-Dependent Changes in Mouse Heart, Muscle, and Brain, Endocrinology, 156, 3885, 10.1210/en.2015-1628 · DOI
  9. MJ Schafer, 2016, Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease, Cell Metab, 23, 1207, 10.1016/j.cmet.2016.05.023 · DOI
  10. M Ehrlich, 2006, Improvement in the appearance of wrinkles with topical transforming growth factor beta(1) and l-ascorbic acid, Dermatol Surg, 32, 618
  11. E Elghblawi, 2017, Plasma-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering, J Cosmet Dermatol
  12. MS Leo, 2015, Systematic review of the use of platelet-rich plasma in aesthetic dermatology, J Cosmet Dermatol, 14, 315, 10.1111/jocd.12167 · DOI
  13. RE Fitzpatrick, 2003, Reversal of photodamage with topical growth factors: a pilot study, J Cosmet Laser Ther, 5, 25, 10.1080/14764170310000817 · DOI
  14. R Mohan, 2002, Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration, J Biol Chem, 277, 2065, 10.1074/jbc.M107611200 · DOI
  15. T Kobayashi, 2014, Matrix metalloproteinase-9 activates TGF-beta and stimulates fibroblast contraction of collagen gels, Am J Physiol Lung Cell Mol Physiol, 306, L1006, 10.1152/ajplung.00015.2014 · DOI
  16. S Salvioli, 2006, Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology, Curr Pharm Des, 12, 3161, 10.2174/138161206777947470 · DOI
  17. S Xia, 2016, An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment, J Immunol Res, 2016, 8426874
  18. MJ Goumans, 2002, Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors, EMBO J, 21, 1743, 10.1093/emboj/21.7.1743 · DOI
  19. AG Gunin, 2014, Age-related changes in angiogenesis in human dermis, Exp Gerontol, 55, 143, 10.1016/j.exger.2014.04.010 · DOI

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Metadata

Authors
Idkowiak-Baldys, J., Santhanam, U., Buchanan, S. M., Pfaff, K. L., Rubin, L. L., & Lyga, J.
Venue
PLOS ONE
Published
2019-06-10
Volume
14
Issue
6
Pages
e0218035
ISSN
1932-6203
Cited by
28
References
4
Language
en

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