Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

2013 ACCF/AHA Guideline for the Management of Heart Failure

Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536 · see citing works

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

Tuerk, C., & Gold, L. (1990) · Science · doi:10.1126/science.2200121 · Cited by 10,421 · see citing works

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart study

Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699 · see citing works

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,712 · see citing works

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754 · see citing works

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium

Balsam, L. B., Wagers, A. J., Christensen, J. L., Kofidis, T., Weissman, I. L., & Robbins, R. C. (2004) · Nature · doi:10.1038/nature02460 · Cited by 1,737 · see citing works

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564 · see citing works

Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460 · see citing works

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257 · see citing works

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

Zhou, X., Wang, J. L., Lu, J., Song, Y., Kwak, K. S., Jiao, Q., Rosenfeld, R., Chen, Q., Boone, T. C., Simonet, W. S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.011 · Cited by 941 · see citing works

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science · doi:10.1126/science.1064081 · Cited by 933 · see citing works

Induction of Cachexia in Mice by Systemically Administered Myostatin

Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P. A., Esquela‐Kerscher, A., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., & Lee, S. (2002) · Science · doi:10.1126/science.1069525 · Cited by 908 · see citing works

Targeted Metabolomics

Roberts, L. D., Souza, A. L., Gerszten, R. E., & Clish, C. B. (2012) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb3002s98 · Cited by 714 · see citing works

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649 · see citing works

A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice

Krege, J. H., Hodgin, J. B., Hagaman, J. R., & Smithies, O. (1995) · Hypertension · doi:10.1161/01.hyp.25.5.1111 · Cited by 587 · see citing works

Gender differences and aging: Effects on the human heart

Olivetti, G., Giordano, G., Corradi, D., Melissari, M., Lagrasta, C. A. M., Gambert, S. R., & Anversa, P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00282-8 · Cited by 574 · see citing works

Prevention of Heart Failure

Schocken, D. D., Benjamin, E. J., Fonarow, G. C., Krumholz, H. M., Levy, D. A., Mensah, G. A., Narula, J., Stuart‐Shor, E., Young, J. B., & Hong, Y. (2008) · Circulation · doi:10.1161/circulationaha.107.188965 · Cited by 548 · see citing works

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

Lee, S.-J., Reed, L. A., Davies, M. V., Girgenrath, S., Goad, M. E. P., Tomkinson, K. N., Wright, J. F., Barker, C., Ehrmantraut, G., Holmstrom, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505996102 · Cited by 501 · see citing works

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

Dai, D., Santana, L. F., Vermulst, M., Tomazela, D. M., Emond, M. J., MacCoss, M. J., Gollahon, K. A., Martin, G. M., Loeb, L. A., Ladiges, W., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.822403 · Cited by 497 · see citing works

Isolation of Adult Mouse Myogenic Progenitors

Sherwood, R. I., Christensen, J. L., Conboy, I. M., Conboy, M. J., Rando, T. A., Weissman, I. L., & Wagers, A. J. (2004) · Cell · doi:10.1016/j.cell.2004.10.021 · Cited by 491 · see citing works

Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1999) · Nature Genetics · doi:10.1038/10320 · Cited by 471 · see citing works

Epidemiology of Diastolic Heart Failure

Owan, T. E., & Redfield, M. M. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.02.010 · Cited by 419 · see citing works

Interleukin-33 Prevents Apoptosis and Improves Survival After Experimental Myocardial Infarction Through ST2 Signaling

Seki, K., Sanada, S., Kudinova, A. Y., Steinhauser, M. L., Handa, V., Gannon, J., & Lee, R. T. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.873240 · Cited by 364 · see citing works

Assigning the Positional Identity of Spinal Motor Neurons

Liu, J.-P., Laufer, E., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00544-x · Cited by 329 · see citing works

Use of tibial length to quantify cardiac hypertrophy: application in the aging rat

Yin, F. C. P., Spurgeon, H. A., Rakusan, K., Weisfeldt, M. L., & Lakatta, E. G. (1982) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1982.243.6.h941 · Cited by 296 · see citing works

Promiscuity and specificity in BMP receptor activation

Mueller, T. D., & Nickel, J. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.02.043 · Cited by 285 · see citing works

Ovulated oocytes in adult mice derive from non-circulating germ cells

Eggan, K. C., Jurga, S., Gosden, R. G., Min, I. M., & Wagers, A. J. (2006) · Nature · doi:10.1038/nature04929 · Cited by 247 · see citing works

Expression of growth/differentiation factor 11, a new member of the BMP/TGFβ superfamily during mouse embryogenesis

Nakashima, M., Toyono, T., Akamine, A., & Joyner, A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00205-6 · Cited by 240 · see citing works

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

Conboy, I. M., & Rando, T. A. (2012) · Cell Cycle · doi:10.4161/cc.20437 · Cited by 239 · see citing works

GDF11 Controls the Timing of Progenitor Cell Competence in Developing Retina

Kim, J., Wu, H., Lander, A. D., Lyons, K. M., Matzuk, M. M., & Calof, A. L. (2005) · Science · doi:10.1126/science.1110175 · Cited by 234 · see citing works

An improved method of parabiosis

Bunster, E., & Meyer, R. K. (1933) · The Anatomical Record · doi:10.1002/ar.1090570404 · Cited by 222 · see citing works

Transcriptional effects of chronic Akt activation in the heart

Cook, S. A., Matsui, T., Li, L., & Rosenzweig, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201462200 · Cited by 199 · see citing works

A Novel BMP Expressed in Developing Mouse Limb, Spinal Cord, and Tail Bud Is a Potent Mesoderm Inducer inXenopusEmbryos

Gamer, L. W., Wolfman, N. M., Celeste, A. J., Hattersley, G., Hewick, R. M., & Rosen, V. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9191 · Cited by 170 · see citing works

Redundancy of myostatin and growth/differentiation factor 11 function

McPherron, A. C., Huynh, T. V., & Lee, S.-J. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-24 · Cited by 164 · see citing works

Signal Transduction Pathway through Activin Receptors as a Therapeutic Target of Musculoskeletal Diseases and Cancer

Tsuchida, K., Nakatani, M., Uezumi, A., Murakami, T., & Cui, X. (2008) · Endocrine Journal · doi:10.1507/endocrj.kr-110 · Cited by 163 · see citing works

GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development

Harmon, E. B., Apelqvist, Å., Smart, N. G., Gu, X., Osborne, D. H., & Kim, S. K. (2004) · Development · doi:10.1242/dev.01535 · Cited by 160 · see citing works

GDF11 Forms a Bone Morphogenetic Protein 1-Activated Latent Complex That Can Modulate Nerve Growth Factor-Induced Differentiation of PC12 Cells

Ge, G., Hopkins, D. R., Ho, W., & Greenspan, D. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5846-5858.2005 · Cited by 158 · see citing works

Parabiosis in Physiological Studies

Finerty, J. C. (1952) · Physiological Reviews · doi:10.1152/physrev.1952.32.3.277 · Cited by 147 · see citing works

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

Souza, T. A., Chen, X., Guo, Y., Sava, P., Zhang, J., Hill, J. J., Yaworsky, P. J., & Qiu, Y. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0290 · Cited by 142 · see citing works

Impact of Exercise Training on Myostatin Expression in the Myocardium and Skeletal Muscle in a Chronic Heart Failure Model

Lenk, K., Schur, R., Linke, A., Erbs, S., Matsumoto, Y., Adams, V., & Schuler, G. C. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp020 · Cited by 136 · see citing works

Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting

Breitbart, A., Auger‐Messier, M., Molkentin, J. D., & Heineke, J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00200.2011 · Cited by 131 · see citing works

Metabolic Functions of Myostatin and GDF11

McPherron, A. C. (2010) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152210793663810 · Cited by 125 · see citing works

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

Salpeter, S. J., Khalaileh, A., Weinberg-Corem, N., Ziv, O., Glaser, B., & Dor, Y. (2013) · Diabetes · doi:10.2337/db13-0160 · Cited by 122 · see citing works

Targeted Deletion of Thioredoxin-Interacting Protein Regulates Cardiac Dysfunction in Response to Pressure Overload

Yoshioka, J., Imahashi, K., Gabel, S. A., Chutkow, W. A., Burds, A. A., Gannon, J., Schulze, P. C., MacGillivray, C., London, R. E., Murphy, E., et al. (2007) · Circulation Research · doi:10.1161/circresaha.106.160515 · Cited by 115 · see citing works

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

Fournier, B., Murray, B., Gutzwiller, S., Marcaletti, S., Marcellin, D., Bergling, S., Brachat, S., Persohn, E., Pierrel, E., Bombard, F., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06575-11 · Cited by 108 · see citing works

Myostatin expression in ventricular myocardium in a rat model of volume‐overload heart failure

Shyu, K., Lu, M.-J., Wang, B. W., Sun, H.-Y., & Chang, H. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01718.x · Cited by 100 · see citing works

Diastolic Heart Failure — A Common and Lethal Condition by Any Name

Aurigemma, G. P. (2006) · New England Journal of Medicine · doi:10.1056/nejme068128 · Cited by 93 · see citing works

Myostatin does not regulate cardiac hypertrophy or fibrosis

Cohn, R. D., Liang, H.-Y., Shetty, R., Abraham, T. P., & Wagner, K. R. (2007) · Neuromuscular Disorders · doi:10.1016/j.nmd.2007.01.011 · Cited by 88 · see citing works

Cardiac 1-adrenergic drive in pathological remodelling

Woodcock, E. A., Du, X.-J., Reichelt, M. E., & Graham, R. M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm078 · Cited by 82 · see citing works

Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability

Foryst‐Ludwig, A., Kreissl, M. C., Sprang, C., Thalke, B., Böhm, C., Benz, V., Gürgen, D., Dragun, D., Schubert, C., Mai, K., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01222.2010 · Cited by 82 · see citing works

Myostatin represses physiological hypertrophy of the heart and excitation–contraction coupling

Rodgers, B. D., Interlichia, J. P., Garikipati, D. K., Mamidi, R., Chandra, M., Nelson, O. L., Murry, C. E., & Santana, L. F. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172544 · Cited by 73 · see citing works

Loss of mXinα, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects

Gustafson-Wagner, E. A., Sinn, H. W., Chen, Y., Wang, D., Reiter, R. S., Lin, J. J., Yang, B., Williamson, R. A., Chen, J., Lin, C., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00806.2007 · Cited by 73 · see citing works

The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphism

Jackson, M. F., Luong, D., Vang, D. D., Garikipati, D. K., Stanton, J. B., Nelson, O. L., & Rodgers, B. D. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0455 · Cited by 64 · see citing works

Analysis of pancreatic endocrine development in GDF11‐deficient mice

Dichmann, D. S., Yassin, H., & Serup, P. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20953 · Cited by 62 · see citing works

Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse

Artaza, J. N., Reisz‐Porszasz, S., Dow, J., Kloner, R. A., Tsao, J., Bhasin, S., & González-Cadavid, N. F. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0072 · Cited by 56 · see citing works

β 3 Integrin‐mediated ubiquitination activates survival signaling during myocardial hypertrophy

Johnston, R. K., Balasubramanian, S., Kasiganesan, H., Baicu, C. F., Zile, M. R., & Kuppuswamy, D. (2009) · The FASEB Journal · doi:10.1096/fj.08-127480 · Cited by 56 · see citing works

Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation

McKoy, G., Bicknell, K. A., Patel, K., & BROOKS, G. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.023 · Cited by 49 · see citing works

Diastolic Heart Failure in the Elderly

Kitzman, D. W., & Daniel, K. R. (2007) · Heart Failure Clinics · doi:10.1016/j.hfc.2007.07.008 · Cited by 48 · see citing works

Improved Cutaneous Healing in Diabetic Mice Exposed to Healthy Peripheral Circulation

Pietramaggiori, G., Scherer, S. S., Alperovich, M. A., Chen, B., Orgill, D. P., & Wagers, A. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.60 · Cited by 43 · see citing works

Diastolic Heart Failure in the Elderly

Kitzman, D. W., & Daniel, K. R. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2006.09.002 · Cited by 15 · see citing works

Untitled work

Allen (1999) · doi:10.1002/(sici)1097-4652(199907)180:1

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works

Sarcopenia: Aging-Related Loss of Muscle Mass and Function

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works

TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology

Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321 · see citing works

Ageing, neurodegeneration and brain rejuvenation

Wyss-Coray, T. (2016) · Nature · doi:10.1038/nature20411 · Cited by 1,147 · see citing works

Muscle wasting in disease: molecular mechanisms and promising therapies

Cohen, S., Nathan, J. A., & Goldberg, A. L. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4467 · Cited by 1,089 · see citing works

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037 · see citing works

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap

Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A., & Paulus, W. J. (2016) · Circulation · doi:10.1161/circulationaha.116.021884 · Cited by 1,003 · see citing works

Undulating changes in human plasma proteome profiles across the lifespan

Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0673-2 · Cited by 981 · see citing works

Physiological and pathological cardiac hypertrophy

Shimizu, I., & Minamino, T. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.06.001 · Cited by 892 · see citing works

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

Ferenbach, D. A., & Bonventre, J. V. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.3 · Cited by 880 · see citing works

BMP signalling in skeletal development, disease and repair

Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 848 · see citing works

Cardioimmunology: the immune system in cardiac homeostasis and disease

Świrski, F. K., & Nahrendorf, M. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 853 · see citing works

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824 · see citing works

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

The pathophysiology of heart failure with preserved ejection fraction

Borlaug, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.83 · Cited by 726 · see citing works

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.03.002 · Cited by 686 · see citing works

Emerging interactions between skin stem cells and their niches

Hsu, Y., Li, L., & Fuchs, E. V. (2014) · Nature Medicine · doi:10.1038/nm.3643 · Cited by 563 · see citing works

Measuring biological age using omics data

Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570 · see citing works

Anemia in Clinical Practice—Definition and Classification: Does Hemoglobin Change With Aging?

Cappellini, M. D., & Motta, I. (2015) · Seminars in Hematology · doi:10.1053/j.seminhematol.2015.07.006 · Cited by 564 · see citing works

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

Rohloff, J. C., Gelinas, A. D., Jarvis, T. C., Ochsner, U. A., Schneider, D. J., Gold, L., & Janjic, N. (2014) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2014.49 · Cited by 533 · see citing works

GDF11 increases with age and inhibits skeletal muscle regeneration

Egerman, M. A., Cadena, S. M., Gilbert, J. A., Meyer, A., Nelson, H. N., Swalley, S. E., Mallozzi, C., Jacobi, C., Jennings, L. L., Clay, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.010 · Cited by 527 · see citing works

Renal Aging: Causes and Consequences

O’Sullivan, E. D., Hughes, J., & Ferenbach, D. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121308 · Cited by 484 · see citing works

The quest to slow ageing through drug discovery

Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Thomas, R., Wang, W., & Su, D.-M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-0173-8 · Cited by 442 · see citing works

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Castellano, J. M., Mosher, K. I., Abbey, R. J., McBride, A. A., James, M. L., Berdnik, D., Shen, J. C., Zou, B., Xie, X. S., Tingle, M., et al. (2017) · Nature · doi:10.1038/nature22067 · Cited by 445 · see citing works

The central role of muscle stem cells in regenerative failure with aging

Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437 · see citing works

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

Suragani, R. N. V. S., Cadena, S. M., Cawley, S. M., Sako, D., Mitchell, D., Li, R., Davies, M. V., Alexander, M. J., Devine, M., Loveday, K. S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3512 · Cited by 452 · see citing works

Aging and Autophagy in the Heart

Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.307474 · Cited by 443 · see citing works

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms5082 · Cited by 411 · see citing works

Assessment of Variability in the SOMAscan Assay

Candia, J., Cheung, F., Kotliarov, Y., Fantoni, G., Sellers, B. A., Griesman, T., Huang, J., Stuccio, S., Zingone, A., Ryan, B. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14755-5 · Cited by 399 · see citing works

The Regulation of Cell Size

Lloyd, A. C. (2013) · Cell · doi:10.1016/j.cell.2013.08.053 · Cited by 393 · see citing works

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Hausenloy, D. J., García‐Dorado, D., Bøtker, H. E., Davidson, S. M., Downey, J. M., Engel, F. B., Jennings, R. B., Lecour, S., Leor, J., Madonna, R., et al. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx049 · Cited by 354 · see citing works

The role of matrix metalloproteinases in aging: Tissue remodeling and beyond

Freitas‐Rodríguez, S., Folgueras, A. R., & López-Otı́n, C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.05.007 · Cited by 367 · see citing works

When stem cells grow old: phenotypes and mechanisms of stem cell aging

Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331 · see citing works

Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease

Almada, A. E., & Wagers, A. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.7 · Cited by 314 · see citing works

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

Hathout, Y., Brody, E. N., Clemens, P. R., Cripe, L. H., DeLisle, R. K., Furlong, P., Gordish‐Dressman, H., Hache, L. P., Henricson, E., Hoffman, E. P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507719112 · Cited by 291 · see citing works

Anemia: progress in molecular mechanisms and therapies

Sankaran, V. G., & Weiss, M. J. (2015) · Nature Medicine · doi:10.1038/nm.3814 · Cited by 279 · see citing works

TGF-β signaling in the control of hematopoietic stem cells

Blank, U., & Karlsson, S. (2015) · Blood · doi:10.1182/blood-2014-12-618090 · Cited by 277 · see citing works

Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology

Hodgkinson, C. P., Bareja, A., Gomez, J. A., & Dzau, V. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.305373 · Cited by 276 · see citing works

Targeting Age-Related Pathways in Heart Failure

Li, H., Hastings, M. H., Rhee, J., Trager, L. E., Roh, J. D., & Rosenzweig, A. (2020) · Circulation Research · doi:10.1161/circresaha.119.315889 · Cited by 270 · see citing works

The Role of the TGF-β Superfamily in Myocardial Infarction

Hanna, A., & Frangogiannis, N. G. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00140 · Cited by 253 · see citing works

Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.

Fu, Y., Huang, C., Xu, X., Gu, H., Ye, Y., Jiang, C., Qiu, Z., & Xie, X. (2015) · Cell Research · doi:10.1038/cr.2015.99 · Cited by 248 · see citing works

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

Salzer, M. C., Lafzi, A., Berenguer, A., Youssif, C., Castellanos‐Martín, A., Solanas, G., Peixoto, F. O., Attolini, C. S., Prats, N., Aguilera, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.012 · Cited by 243 · see citing works

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.012 · Cited by 233 · see citing works

Molecular mechanisms of renal aging

Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235 · see citing works

Changes in Regenerative Capacity through Lifespan

Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works

Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease

Camici, G. G., Savarese, G., Akhmedov, A., & Lüscher, T. F. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv587 · Cited by 223 · see citing works

Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response

Silva, A. C., Pereira, C., Fonseca, A. C. R. G., Pinto‐do‐Ó, P., & Nascimento, D. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.621644 · Cited by 219 · see citing works

Interorgan Communication Pathways in Physiology: Focus on Drosophila

Droujinine, I. A., & Perrimon, N. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-122024 · Cited by 205 · see citing works

Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production

Sawaki, D., Czibik, G., Pini, M., Ternacle, J., Suffee, N., Mercedes, R., Marcelin, G., Surénaud, M., Marcos, É., Gual, P., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.031358 · Cited by 217 · see citing works

Relevance of the p53–MDM2 axis to aging

Wu, D., & Prives, C. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.187 · Cited by 215 · see citing works

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., Wei, Q., & Alman, B. A. (2015) · Nature Communications · doi:10.1038/ncomms8131 · Cited by 211 · see citing works

The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life SpanPreprint

Sierra, F. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025163 · Cited by 213 · see citing works

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage

Fafián-Labora, J. A., Rodríguez-Navarro, J. A., & O’Loghlen, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.004 · Cited by 203 · see citing works

Biochemistry and Biology of GDF11 and Myostatin

Walker, R. G., Poggioli, T., Katsimpardi, L., Buchanan, S. M., Oh, J., Wattrus, S. J., Heidecker, B., Fong, Y. W., Rubin, L. L., Ganz, P., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308391 · Cited by 210 · see citing works

Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease

Smith, J. G., & Gerszten, R. E. (2017) · Circulation · doi:10.1161/circulationaha.116.025446 · Cited by 209 · see citing works

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B. R., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.023 · Cited by 206 · see citing works

The Aging Heart: Figure 1.Preprint

Chiao, Y. A., & Rabinovitch, P. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025148 · Cited by 198 · see citing works

Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age‐related disorders

Fujita, Y., Taniguchi, Y., Shinkai, S., Tanaka, M., & Ito, M. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12724 · Cited by 199 · see citing works

Circulating Growth Differentiation Factor 11/8 Levels Decline With Age

Poggioli, T., Vujić, A., Yang, P., Macias-Treviño, C., Uygur, A., Loffredo, F. S., Pancoast, J. R., Cho, M., Goldstein, J., Tandias, R. M., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.307521 · Cited by 192 · see citing works

Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models

Roh, J. D., Hill, J. A., Singh, A. S. C., Valero‐Muñoz, M., & Sam, F. (2022) · Circulation Research · doi:10.1161/circresaha.122.320257 · Cited by 193 · see citing works

Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

Buckley, M. T., Sun, E., George, B. M., Liu, L. A., Schaum, N., Xu, L., Reyes, J. M., Goodell, M. A., Weissman, I. L., Wyss‐Coray, T., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00335-4 · Cited by 189 · see citing works

Activin A more prominently regulates muscle mass in primates than does GDF8

Latres, E., Mastaitis, J., Fury, W., Miloscio, L., Trejos, J., Pangilinan, J., Okamoto, H., Cavino, K., Na, E., Papatheodorou, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15153 · Cited by 185 · see citing works

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency

Studer, L., Vera, E., & Cornacchia, D. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.004 · Cited by 186 · see citing works

Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies

Stenvinkel, P., Carrero, J. J., von Walden, F., Ikizler, T. A., & Nader, G. A. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv122 · Cited by 186 · see citing works

GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy

Smith, S., Zhang, X., Zhang, X., Gross, P., Starosta, T., Mohsin, S., Franti, M., Gupta, P., Hayes, D., Myzithras, M., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.307527 · Cited by 185 · see citing works

Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction

Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., Mentz, R. J., Borlaug, B. A., Simon, M. A., Chirinos, J. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.014 · Cited by 184 · see citing works

Nfatc1 orchestrates aging in hair follicle stem cells

Keyes, B. E., Segal, J. P., Heller, E., Lien, W., Chang, C.-Y., Guo, X., Oristian, D., Zheng, D., & Fuchs, E. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320301110 · Cited by 178 · see citing works

Heart Failure With Preserved Ejection Fraction

Loffredo, F. S., Nikolova, A., Pancoast, J. R., & Lee, R. T. (2014) · Circulation Research · doi:10.1161/circresaha.115.302929 · Cited by 181 · see citing works

Extracellular vesicles deposit <i>PCNA</i> to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Lei, Q., Gao, F., Liu, T., Ren, W., Chen, L., Cao, Y., Chen, W., Guo, S., Zhang, Q., Chen, W., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8697 · Cited by 170 · see citing works

New insights into iron regulation and erythropoiesis

Kim, A., & Nemeth, E. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000132 · Cited by 173 · see citing works

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 166 · see citing works

Mesenchymal stem cell therapy: A promising cell‐based therapy for treatment of myocardial infarction

Shafei, A., ALI, M. A. M., Ghanem, H. G., Shehata, A. I., Abdelgawad, A. A., Handal, H. R., Talaat, K. A., Ashaal, A. E., & El‐Shal, A. S. (2017) · The Journal of Gene Medicine · doi:10.1002/jgm.2995 · Cited by 165 · see citing works

Turning back time with emerging rejuvenation strategies

Mahmoudi, S., Xu, L., & Brunet, A. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0206-0 · Cited by 163 · see citing works

The Role of Exercise in Cardiac Aging

Roh, J. D., Rhee, J., Chaudhari, V., & Rosenzweig, A. (2016) · Circulation Research · doi:10.1161/circresaha.115.305250 · Cited by 160 · see citing works

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Ji, S., Xiong, M., Chen, H., Liu, Y., Zhou, L., Hong, Y., Wang, M., Wang, C., Fu, X., & Sun, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01343-5 · Cited by 166 · see citing works

Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps

Bączek, J., Silkiewicz, M., & Wojszel, Z. B. (2020) · Nutrients · doi:10.3390/nu12082401 · Cited by 159 · see citing works

Blood-to-brain communication in aging and rejuvenation

Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01238-8 · Cited by 156 · see citing works

GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation

Liu, W., Zhou, L., Zhou, C., Zhang, S., Jing, J., Xie, L., Sun, N., Duan, X., Jing, W., Liang, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms12794 · Cited by 156 · see citing works

Rejuvenating Strategies for Stem Cell-Based Therapies in Aging

Neves, J., Sousa‐Victor, P., & Jasper, H. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.01.008 · Cited by 156 · see citing works

Emerging Anti-Aging Strategies - Scientific Basis and Efficacy

Shetty, A. K., Kodali, M., Upadhya, R., & Madhu, L. N. (2018) · Aging and Disease · doi:10.14336/ad.2018.1026 · Cited by 148 · see citing works

Activin type II receptor signaling in cardiac aging and heart failure

Roh, J. D., Hobson, R., Chaudhari, V., Quintero, P. A., Yeri, A., Benson, M. D., Xiao, C., Zlotoff, D. A., Bezzerides, V. J., Houstis, N. E., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau8680 · Cited by 148 · see citing works

The aging heart

Obas, V., & Vasan, R. S. (2018) · Clinical Science · doi:10.1042/cs20171156 · Cited by 148 · see citing works

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Latres, E., Pangilinan, J., Miloscio, L., Bauerlein, R., Na, E., Potocky, T. B., Huang, Y., Eckersdorff, M., Rafique, A., Mastaitis, J., et al. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0060-8 · Cited by 143 · see citing works

Circulating Proteomic Signatures of Chronological Age

Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., et al. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu121 · Cited by 144 · see citing works

Strategies and Challenges in Clinical Trials Targeting Human Aging

Newman, J. C., Milman, S., Hashmi, S. K., Austad, S. N., Kirkland, J. L., Halter, J. B., & Barzilai, N. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw149 · Cited by 137 · see citing works

Neurogenesis in the aging brain

Apple, D. M., Fonseca, R. S., & Kokovay, E. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.116 · Cited by 140 · see citing works

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00451-9 · Cited by 134 · see citing works

Antibody‐based proteomics and biomarker research—Current status and limitations

Solier, C., & Langen, H. (2014) · PROTEOMICS · doi:10.1002/pmic.201300334 · Cited by 131 · see citing works

Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway

Demontis, F., Patel, V. K., Swindell, W. R., & Perrimon, N. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.001 · Cited by 131 · see citing works

Association of Blood Donor Age and Sex With Recipient Survival After Red Blood Cell Transfusion

Chassé, M., Tinmouth, A. T., English, S. W., Acker, J. P., Wilson, K. R., Knoll, G. A., Shehata, N., van Walraven, C., Forster, A. J., Ramsay, T., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.3324 · Cited by 130 · see citing works

Paracrine signals regulate human liver organoid maturation from iPSC

Asai, A., Aihara, E., Watson, C. L., Mourya, R., Mizuochi, T., Shivakumar, P., Phelan, K. J., Mayhew, C. N., Helmrath, M. A., Takebe, T., et al. (2017) · Development · doi:10.1242/dev.142794 · Cited by 130 · see citing works

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

Sousa‐Victor, P., Neves, J., Cedron-Craft, W., Ventura, P. B., Liao, C., Riley, R. R., Soifer, I., van Bruggen, N., Kolumam, G. A., Villeda, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0023-6 · Cited by 127 · see citing works

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Sanz-Ros, J., Romero-García, N., Mas-Bargues, C., Monleón, D., Gordevicius, J., Brooke, R. T., Dromant, M., Díaz, A., Derevyanko, A., Guío-Carrión, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq2226 · Cited by 131 · see citing works

Cellular reprogramming and epigenetic rejuvenation

Simpson, D. J., Olova, N. N., & Chandra, T. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01158-7 · Cited by 123 · see citing works

Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease

Wallin, A., Román, G. C., Esiri, M. M., Kettunen, P., Svensson, J., Paraskevas, G. P., & Kapaki, E. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170803 · Cited by 130 · see citing works

Syndrome d'alcoolisme fœtal et sténose du pylore

Dehaene, P. (1999) · Archives de Pédiatrie · doi:10.1016/s0929-693x(99)80084-0 · Cited by 4 · see citing works

M o ao

(2016)

Diversa and Du Pont in enzyme jv

(2002) · Focus on Catalysts · doi:10.1016/s1351-4180(02)01011-5

Young at Heart

Leinwand, L. A., & Harrison, B. C. (2013) · Cell · doi:10.1016/j.cell.2013.04.038 · Cited by 5 · see citing works

Rejuvenation of Aging Hearts

Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1462 · Cited by 10 · see citing works