Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 33

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial

Doenyas-Barak, Keren, Catalogna, Merav, Kutz, Ilan, Levi, Gabriela, Hadanny, Amir, Tal, Sigal, Daphna-Tekoha, Shir, Sasson, Efrat, Shechter, Yarden, Efrati, Shai·2022·PLOS ONE
DOI 10.1371/journal.pone.0264161
Open this paper in CoChat — free account

Abstract

Introduction: Post-traumatic stress disorder (PTSD) is characterized by changes in both brain activity and microstructural integrity. Cumulative evidence demonstrates that hyperbaric oxygen therapy (HBOT) induces neuroplasticity and case-series studies indicate its potentially positive effects on PTSD. The aim of the study was to evaluate HBOT’s effect in veterans with treatment resistant PTSD. Methods: Veterans with treatment resistant PTSD were 1:1 randomized to HBOT or control groups. All other brain pathologies served as exclusion criteria. Outcome measures included clinician-administered PTSD scale-V (CAPS-V) questionnaires, brief symptom inventory (BSI), BECK depression inventory (BDI), brain microstructural integrity evaluated by MRI diffuse tensor imaging sequence (DTI), and brain function was evaluated by an n-back task using functional MRI (fMRI). The treatment group underwent sixty daily hyperbaric sessions. No interventions were performed in the control group. Results: Thirty-five veterans were randomized to HBOT (N = 18) or control (n = 17) and 29 completed the protocol. Following HBOT, there was a significant improvement in CAPS-V scores and no change in the control (F = 30.57, P<0.0001, Net effect size = 1.64). Significant improvements were also demonstrated in BSI and BDI scores (F = 5.72, P = 0.024 Net effect size = 0.89, and F = 7.65, P = 0.01, Net effect size = 1.03). Improved brain activity was seen in fMRI in the left dorsolateral prefrontal, middle temporal gyri, both thalami, left hippocampus and left insula. The DTI showed significant increases in fractional anisotropy in the fronto-limbic white-matter, genu of the corpus callosum and fornix. Conclusions: HBOT improved symptoms, brain microstructure and functionality in veterans with treatment resistant PTSD.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0264161

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 25

  1. American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders: DSM-5, 10.1176/appi.books.9780890425596 · DOI · Paper page
  2. AL Gold, 2011, Decreased regional cerebral blood flow in medial prefrontal cortex during trauma-unrelated stressful imagery in Vietnam veterans with post-traumatic stress disorder, Psychol Med, 41, 2563, 10.1017/S0033291711000730 · DOI
  3. G Sartory, 2013, In search of the trauma memory: a meta-analysis of functional neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD), PLoS One, 8, 58150, 10.1371/journal.pone.0058150 · DOI · Paper page
  4. JP Hayes, 2012, Quantitative meta-analysis of neural activity in posttraumatic stress disorder, Biol Mood Anxiety Disord, 2, 9, 10.1186/2045-5380-2-9 · DOI · Paper page
  5. S Efrati, 2014, Reflections on the neurotherapeutic effects of hyperbaric oxygen, Expert Rev Neurother, 14, 233, 10.1586/14737175.2014.884928 · DOI
  6. S Efrati, 2013, Hyperbaric oxygen induces late neuroplasticity in post stroke patients—randomized, prospective trial, PLoS One, 8, 53716, 10.1371/journal.pone.0053716 · DOI · Paper page
  7. R Boussi-Gross, 2013, Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury—randomized prospective trial, PLoS One, 8, e79995, 10.1371/journal.pone.0079995 · DOI · Paper page
  8. A Hadanny, 2018, Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse-Randomized Controlled Trial, Front Psychol, 9, 2495, 10.3389/fpsyg.2018.02495 · DOI
  9. S Efrati, 2018, Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen—Case Series Presentation and Suggested Bio-Psycho-Social Mechanism, Front Psychol, 9, 848, 10.3389/fpsyg.2018.00848 · DOI
  10. BR Mozayeni, 2019, The National Brain Injury Rescue and Rehabilitation Study—a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms, Med Gas Res, 9, 1
  11. RS Miller, 2015, Effects of hyperbaric oxygen on symptoms and quality of life among service members with persistent postconcussion symptoms: a randomized clinical trial, JAMA Intern Med, 175, 43, 10.1001/jamainternmed.2014.5479 · DOI
  12. PG Harch, 2012, A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder., J Neurotrauma, 29, 168, 10.1089/neu.2011.1895 · DOI · Paper page
  13. PG Harch, 2017, Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder., Med Gas Res, 7, 156, 10.4103/2045-9912.215745 · DOI
  14. G Wolf, 2012, The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury, J Neurotrauma, 29, 2606, 10.1089/neu.2012.2549 · DOI
  15. DX Cifu, 2014, The effect of hyperbaric oxygen on persistent postconcussion symptoms, J Head Trauma Rehabil, 29, 11, 10.1097/HTR.0b013e3182a6aaf0 · DOI
  16. LK Weaver, 2018, Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial, Undersea Hyperb Med, 45, 129, 10.22462/03.04.2018.1 · DOI
  17. GM Doniger, 2013, Construct validity of mindstreams: comparison with paper-based tests
  18. Y Benjamini, 1995, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal statistical society: series B (Methodological), 57, 289, 10.1111/j.2517-6161.1995.tb02031.x · DOI · Paper page
  19. Y. Hochberg, 1988, A sharper Bonferroni procedure for multiple tests of significance, Biometrika, 75, 800, 10.1093/biomet/75.4.800 · DOI · Paper page
  20. EA Olson, 2017, Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study, Depress Anxiety, 34, 437, 10.1002/da.22615 · DOI · Paper page
  21. YW Sun, 2015, Inter-hemispheric functional and anatomical connectivity abnormalities in traffic accident-induced PTSD: a study combining fMRI and DTI, J Affect Disord, 188, 80, 10.1016/j.jad.2015.08.021 · DOI
  22. S Kida, 2019, Reconsolidation/destabilization, extinction and forgetting of fear memory as therapeutic targets for PTSD, Psychopharmacology (Berl), 236, 49, 10.1007/s00213-018-5086-2 · DOI
  23. AJ Garcia, 2010, Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons, J Appl Physiol, 109, 804, 10.1152/japplphysiol.91429.2008 · doi:10.1152/japplphysiol.91429.2008
  24. M Khacho, 2019, Mitochondria as central regulators of neural stem cell fate and cognitive function, Nat Rev Neurosci, 20, 34, 10.1038/s41583-018-0091-3 · DOI · Paper page
  25. C Hamani, 2018, Memory enhancement induced by hypothalamic/fornix deep brain stimulation, Ann Neurol, 63, 119, 10.1002/ana.21295 · DOI · Paper page

Cited by

Metadata

Authors
Doenyas-Barak, K., Catalogna, M., Kutz, I., Levi, G., Hadanny, A., Tal, S., Daphna-Tekoha, S., Sasson, E., Shechter, Y., & Efrati, S.
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2022-02-22
Volume
17
Issue
2
Pages
e0264161
ISSN
1932-6203
DOI
10.1371/journal.pone.0264161
Cited by
33
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Research Fund of Shamir Medical Center, Israel

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.