Reduced white matter integrity in the cingulum and anterior corona radiata in posttraumatic stress disorder in male combat veterans: a diffusion tensor imaging study
Open accessAbstract
Posttraumatic stress (PTSD) and alcohol use (AUD) disorders are associated with abnormal anterior cingulate cortex/ventromedial prefrontal cortex, thalamus, and amygdala function, yet microstructural white matter (WM) differences in executive-limbic tracts are likely also involved. Investigating WM in limbic-thalamo-cortical tracts, this study hypothesized (1) fractional anisotropy (FA) in dorsal cingulum, parahippocampal cingulum, and anterior corona radiata (ACR) would be lower in individuals with comorbid PTSD/AUD compared to in individuals with AUD-only and (2) that FA would be related to both AUD and PTSD severity. 22 combat veterans with comorbid PTSD/AUD or AUD-only completed DTI scans. ANCOVAs indicated lower FA in right (F(df=1,19)=9.091, P=0.0071) and left (F(df=1,19)=10.375, P=0.0045) dorsal cingulum and right ACR (F(df=1,19)=18.914, P=0.0003) for individuals with comorbid PTSD/AUD vs. individuals with AUD-only, even controlling for alcohol use. Multiple linear regressions revealed that FA in the right ACR was inversely related to PTSD severity (r=-0.683, P=0.004). FA was not significantly related to alcohol severity. Reduced WM integrity in limbic-thalamo-cortical tracts is implicated in PTSD, even in the presence of comorbid AUD. These findings suggest that diminished WM integrity in tracts important for top-down control may be an important anomaly in PTSD and/or comorbid PTSD/AUD.
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In PTSD, tract volume changes are most frequent in the left hemisphere, while dMRI changes occur in the dorsal cingulum.
“There is evidence that tract volume changes are most frequent in the left hemisphere, while the dMRI changes occur in the dorsal cingulum (e.g., Sanjuan et al., 2013).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Sanjuan et al., 2013
The Discussion (section 4) reports DTI differences in both the left and right dorsal cingulum, supporting the dMRI portion. The Methods (section 2.2) describe measurements of diffusion metrics using the same regional volume across subjects; they do not support a claim that tract-volume changes are most frequent in the left hemisphere. Page numbers were unavailable in our copy. (LLM, conf=0.88)
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- Authors
- Sanjuan, P. M., Thoma, R., Claus, E. D., Mays, N., & Caprihan, A.
- Affiliations
- Mind Research Network (US)
- University of New Mexico (US)
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 214
- Issue
- 3
- Pages
- 260-268
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3988979
- OpenAlex
- W2025513801
- Cited by
- 125
- References
- 15
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 4 · 2013: 1
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Energy
- U.S. Public Health Service (NIAAAT32AA018108-02)
- National Institute on Alcohol Abuse and Alcoholism (K23AA016544, L30 AA019906, T32AA018108)
- National Institute on Drug Abuse (L30 DA025498)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, alcoholism, comorbidities, white matter integrity, fractional anisotropy, combat veterans, PTSD symptom severity, top-down control
- MeSH terms
- Adult, Alcohol Drinking, Axons, Gyrus Cinguli, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Stress Disorders, Post-Traumatic, Thalamus, Veterans, Anisotropy, Prefrontal Cortex, Young Adult, Diffusion Tensor Imaging
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