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Cited by 47Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceBacterial Identification and Susceptibility Testing

Phenotypic and genotypic detection of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in Accra, Ghana

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Dwomoh, Felicia P., Kotey, Fleischer C. N., Dayie, Nicholas T. K. D., Osei, Mary-Magdalene, Amoa-Owusu, Felicia, Bannah, Vida, Alzahrani, Fuad M., Halawani, Ibrahim F. +3 more·2022·PLOS ONE
DOI 10.1371/journal.pone.0279715PMC PMC9803230
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Abstract

Aim: To describe the occurrence of carbapenem resistance among multidrug-resistant (MDR) Escherichia coli and Klebsiella pneumoniae isolated from clinical specimens in Accra using phenotypic and genotypic methods. Methodology: The study was cross-sectional, involving 144 clinical MDR E. coli and K. pneumoniae isolates recovered from the Central Laboratory of the Korle Bu Teaching Hospital (KBTH). The isolates were re-cultured bacteriologically, identified using standard biochemical tests, and subjected to antibiotic susceptibility testing using the Kirby-Bauer method. Carbapenem resistance was determined based on imipenem, meropenem, and ertapenem zones of inhibition, as well as minimum inhibitory concentrations (MICs). Carbapenemase production was determined phenotypically by modified Hodge test (MHT) and modified carbapenem inactivation method (mCIM), and genotypically with multiplex PCR targeting the blaKPC, blaIMP, blaNDM, blaVIM, and blaOXA-48 genes. Results: Of the 144 MDR isolates, 69.4% were E. coli, and 30.6% were K. pneumoniae. The distribution of antimicrobial resistance rates among them was ampicillin (97.2%), cefuroxime (93.1%), sulfamethoxazole-trimethoprim (86.8%), tetracycline (85.4%), cefotaxime and cefpodoxime (77.1% each), amoxicillin-clavulanate (75%), ceftriaxone (73.6%), ciprofloxacin (70.8%), levofloxacin (66.0%), cefepime (65.3%), ceftazidime (64.6%), gentamicin (48.6), piperacillin-tazobactam (40.3%), cefoxitin (14.6%), amikacin (13.9%), ertapenem and meropenem (5.6% each), and imipenem (2.8%). In total, 5.6% (8/144) of them were carbapenem-resistant (carbapenem MIC range = 0.094–32.0 μg/ml), with 75% (6/8) of these testing positive by the phenotypic tests and 62.5% (5/8) by the genotypic test (of which 80% [4/5] carried blaOXA-48 and 20% (1/5) blaNDM). The blaVIM, blaIMP, and blaKPC genes were not detected. Conclusion: Although the rates of antibiotic resistance among the isolates were high, the prevalence of carbapenemase producers was low. The finding of blaOXA-48 and blaNDM warrants upscaling of antimicrobial resistance surveillance programmes and fortification of infection prevention and control programmes in the country.

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  • In six human studies, E. coli exhibited MDR, with prevalence ranging from 41.5% to 99.6%.

    “In six “human studies”, E. coli exhibited MDR, with the prevalence ranging from 41.5% to 99.6% [18,23,27,34,36,41].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [41]

    The Methods (Study site, design, and sampling; page unavailable) describe a human clinical study that included MDR E. coli isolates, so this paper supports its inclusion as one of the cited studies. But the isolates were selected for being MDR, and the Results’ 69.4% is the proportion of selected MDR isolates that were E. coli—not the prevalence of MDR among E. coli. This paper does not establish the stated 41.5%–99.6% prevalence range. (LLM, conf=0.86)

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  1. [1]Labi A, Obeng-Nkrumah N, Addison N, Donkor ES. Salmonella blood stream infections in a tertiary care setting in Ghana. BioMed Central Infectious Diseases 2014; 14(1): 697. PMC4297363 25528352
  2. [2]Obeng-Nkrumah N, Labi AK, Acquah ME, Donkor ES. Bloodstream infections in patients with malignancies: implications for antibiotic treatment in a Ghanaian tertiary setting. BioMed Central Research Notes 2015; 8: 742. doi: 10.1186/s13104-015-1701-z 26628056 PMC4667459 · DOI
  3. [3]Tette EM, Neizer M, Nyarko MY, Sifah EK, Nartey ET, Donkor ES. Changing patterns of disease and mortality at the Children’s Hospital, Accra: Are Infections Rising? PLoS One 2016; 11(4): e0150387. doi: 10.1371/journal.pone.0150387 27045667 PMC4821618 · DOI
  4. [4]Anafo RB, Atiase Y, Dayie NTKD, Kotey FCN, Tetteh-Quarcoo PB, Duodu S, et al. Methicillin-resistant Staphylococcus aureus (MRSA) infection of diabetic foot ulcers at a tertiary care hospital in Accra, Ghana. Pathogens 2021; 10 (8): 937. 34451401 PMC8398970
  5. [5]Dayie NTKD, Bannah V, Dwomoh FP, Kotey FCN, Donkor ES (2022). Distribution and antimicrobial resistance profiles of bacterial aetiologies of childhood otitis media in Accra, Ghana. Microbiology Insights. doi: 10.1177/11786361221104446 35734305 PMC9208041 · DOI
  6. [6]Nordmann P, Naas T, Poirel L. (2011) Global spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17: 1791– 1798. doi: 10.3201/eid1710.110655. 22000347 PMC3310682 · DOI
  7. [7]Lutgring J. D. and Limbago B. M. (2016) ‘ The Problem of Carbapenemase-Producing-Carbapenem-Resistant- Enterobacteriaceae Detection’, Journal of Clinical Microbiology, 54(3), pp. 529– 534. doi: 10.1128/JCM.02771-15 26739152 PMC4767976 · DOI
  8. [8]Agyepong N.; Govinden U.; and Owusu-ofori A. (2018) ‘ Multidrug-resistant gram-negative bacterial infections in a teaching hospital in Ghana’, Antimicrobial Resistance and Infection Control. Antimicrobial Resistance & Infection Control, 7(37), pp. 1– 8. 29541448 PMC5845144
  9. [9]Donkor ES, Badoe EV, Annan JA, Nii-Trebi N. Colonisation of antibiotic resistant bacteria in a cohort of HIV infected children in Ghana. Pan African Medical Journal 2017; 2; 26: 60. PMC5398869 28451037
  10. [10]Falgenhauer L., Imirzalioglu C., Oppong K., Akenten C. W., Hogan B., Krumkamp R., et al. (2019). “ Detection and Characterization of ESBL-Producing Escherichia coli From Humans and Poultry in Ghana”. Frontiers in Microbiology. 9: p. 3358. doi: 10.3389/fmicb.2018.03358 30697208 PMC6340976 · DOI
  11. [11]Hassuna N.A., Khairalla A.S., Farahat E.M., Hammad A.M., Abdel-Fattah M. (2020). Molecular characterization of Extended-spectrum β-lactamase-producing E. coli recovered from community-acquired urinary tract infections in Upper Egypt. Sci Rep 10, 2772. 32066805 PMC7026060
  12. [12]Opintan JA, Newman MJ, Arhin RE, Donkor ES, Gyansa-Lutterodt M, Mills-Pappoe W. Laboratory-based nationwide surveillance of antimicrobial resistance in Ghana. Infection and Drug Resistance. 2015; 8: 379– 389. doi: 10.2147/IDR.S88725 26604806 PMC4655947 · DOI
  13. [14]Obeng-Nkrumah N, Labi AK, Blankson H, Awuah-Mensah G, Oduro-Mensah D, Anum J, et al. Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans. BMC Microbiol. 2019 Dec 4; 19(1): 272. doi: 10.1186/s12866-019-1629-x 31801455 PMC6894353 · DOI
  14. [15]Schwaber MJ, Carmeli Y. (2008). Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA. 300(24): 2911– 3. doi: 10.1001/jama.2008.896 19109119 · DOI
  15. [17]Ho PL, Cheung YY, Wang Y, Lo WU, Lai EL, Chow KH, et al. Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong. Eur J Clin Microbiol Infect Dis. 2016 Mar; 35(3): 379– 85. doi: 10.1007/s10096-015-2550-3 26740321 · DOI
  16. [18]Tischendorf J, de Avila RA, Safdar N. (2016) Risk of infection following colonization with carbapenem-resistant Enterobacteriaceae: A systematic review. Am J Infect Control. 44(5): 539– 43. doi: 10.1016/j.ajic.2015.12.005 26899297 PMC5262497 · DOI
  17. [19]Bartsch SM, McKinnell JA, Mueller LE, Gohil SK, Huang SS, Lee BY. (2017). Potential economic burden of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Clin Microbiol Infect. 23(1): 48.E9– 48.E16. doi: 10.1016/j.cmi.2016.09.003 27642178 PMC5547745 · DOI
  18. [20]Cejas D, Elena A, Guevara Nuñez D, Sevillano Platero P, De Paulis A, Magariños F, et al. Changing epidemiology of KPC-producing Klebsiella pneumoniae in Argentina: Emergence of hypermucoviscous ST25 and high-risk clone ST307. J Glob Antimicrob Resist. 2019 Sep; 18: 238– 242. doi: 10.1016/j.jgar.2019.06.005 31202977 · DOI
  19. [21]Su S, Li C, Zhao Y, Yu L, Wang Y, Wang Y, et al. Outbreak of KPC-2-Producing Klebsiella pneumoniae ST76 Isolates in an Intensive Care Unit and Neurosurgery Unit. Microb Drug Resist. 2020 Sep; 26(9): 1009– 1018. doi: 10.1089/mdr.2019.0363 32150494 · DOI
  20. [22]Saavedra SY, Bernal JF, Montilla-Escudero E, Arévalo SA, Prada DA, Valencia MF, et al. Complexity of Genomic Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolates in Colombia Urges the Reinforcement of Whole Genome Sequencing-Based Surveillance Programs. Clin Infect Dis. 2021 Dec 1; 73(Suppl_4): S290– S299. doi: 10.1093/cid/ciab777 34850835 PMC8634422 · DOI
  21. [23]Nordmann P, Gniadkowski M, Giske CG, Poirel L, Woodford N, Miriagou V. (2012). European Network on Carbapenemases. Identification and screening of carbapenemase-producing Enterobacteriaceae. Clin Microbiol Infect. (5): 432– 8. doi: 10.1111/j.1469-0691.2012.03815.x 22507110 · DOI
  22. [24]WHO (2015). Global Action Plan on Antimicrobial Resistance. Geneva: World Health Organisation. pp. 1–28.
  23. [25]WHO (2014). Antimicrobial Resistance Global Report on Surveillance. Geneva: World Health Organisation. pp. 1–101.
  24. [26]O’Neill Jim, (2014). Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. The review on Antimicrobial Resistance.
  25. [28]Mitgang EA, Hartley DM, Malchione MD, Koch M, Goodman JL. (2018). Review and mapping of carbapenem-resistant Enterobacteriaceae in Africa: Using diverse data to inform surveillance gaps. Int J Antimicrob Agents. 52(3): 372– 384. doi: 10.1016/j.ijantimicag.2018.05.019 29864500 · DOI
  26. [29]Savard P., Carroll K., Wilson L., & Perl T. (2013). The Challenges of Carbapenemase-Producing Enterobacteriaceae and Infection Prevention: Protecting Patients in the Chaos. Infection Control & Hospital Epidemiology, 34(7), 730– 739. doi: 10.1086/671003 23739078 · DOI
  27. [30]Manenzhe RI, Zar HJ, Nicol MP, Kaba M. (2015). The spread of carbapenemase-producing bacteria in Africa: a systematic review. J Antimicrob Chemother. 70(1): 23– 40. doi: 10.1093/jac/dku356 25261423 PMC5975721 · DOI
  28. [31]Owusu-Oduro P. (2016) ‘ Prevalence of Carbapenemase Producing Enterobacteriaceae in Urinary Tract Infection Patients in Ghana’, South American Journal of Public Health, (May), pp. 1– 12.
  29. [32]Hackman H. K., Arhin R. E., Gordon A., Mensah S. N. B., (2017) ‘ Emergence of Carbapenem-resistant Enterobacteriaceae among Extended-spectrum Beta-lactamase Producers in Accra, Ghana’, Journal of Natural Sciences Research, 7(24), pp. 1– 6.
  30. [33]Codjoe F. S, Donkor E. S, Smith T. J, Miller K. (2019) ‘ Phenotypic and Genotypic Characterization of Carbapenem-Resistant Gram-Negative Bacilli Pathogens from Hospitals in Ghana’. Microbial Drug Resistance, 25(10): 1449– 1457. doi: 10.1089/mdr.2018.0278 31237486 · DOI
  31. [34]Eichenberger E. M. and Thaden J. T. (2019) ‘ Epidemiology and mechanisms of resistance of extensively drug-resistant gram-negative bacteria’, Antibiotics, 8(2). doi: 10.3390/antibiotics8020037 30959901 PMC6628318 · DOI
  32. [36]Paveenkittiporn W., Lyman M., Biedron C. et al. Molecular epidemiology of carbapenem-resistant Enterobacterales in Thailand, 2016–2018. Antimicrob Resist Infect Control 10, 88 (2021). doi: 10.1186/s13756-021-00950-7 34090537 PMC8180034 · DOI
  33. [38]Lee K., Chong Y., Shin H. B., Kim Y.A., Yong D., Yum J. H., (2001) ‘ Modified Hodge and EDTA-disk synergy tests to screen Metallo-β-lactamase-producing strains of Pseudomonas and Acinetobacter species’, Clinical Microbiology and Infection, 7(2), pp. 88– 91. doi: 10.1046/j.1469-0691.2001.00204.x 11298149 · DOI
  34. [39]Khurana S., Mathur P., Kapil A., Valsan C., & Behera B. (2017). Molecular epidemiology of beta-lactamase producing nosocomial Gram-negative pathogens from North and South Indian hospitals. Journal of Medical Microbiology. doi: 10.1099/jmm.0.000513 28671522 · DOI
  35. [40]Poirel L, Walsh TR, Cuvillier V, Nordmann P. (2011) ‘ Multiplex PCR for detection of acquired carbapenemase genes’, Diagnostic Microbiology and Infectious Disease. Elsevier Inc., 70(1), pp. 119– 123. doi: 10.1016/j.diagmicrobio.2010.12.002 21398074 · DOI · Paper page
  36. [41]Camara M., Mane M. T., Ba-Diallo A., Dieng A., Diop-Ndiaye H., Karam F., et al. (2017) ‘carbapenemase-producing Enterobacteriaceae clinical isolates in a Senegalese teaching hospital: A cross-sectional study. African Journal of Microbiology Research, 11(44), pp. 1600– 1605. doi: 10.5897/AJMR2017.8716 · DOI
  37. [42]Olowo-Okere A, Ibrahim YKE, Olayinka BO, Ehinmidu JO, Mohammed Y, Nabti LZ, et al. (2020) ‘ Phenotypic and genotypic characterization of clinical carbapenem-resistant Enterobacteriaceae isolates from Sokoto, northwest Nigeria’, New Microbes and New Infections. 1; 37: 100727. doi: 10.1016/j.nmni.2020.100727 32939286 PMC7479348 · DOI
  38. [43]Ballot DE, Bandini R, Nana T, Bosman N, Thomas T, Davies VA, et al. (2019) ‘ A review of -multidrug-resistant Enterobacteriaceae in a neonatal unit in Johannesburg, South Africa’, BMC Pediatrics. 19(1): 320. doi: 10.1186/s12887-019-1709-y 31493789 PMC6731552 · DOI
  39. [44]Okoche D, Asiimwe BB, Katabazi FA, Kato L, Najjuka CF. (2015) ‘ Prevalence and Characterization of Carbapenem-Resistant Enterobacteriaceae Isolated from Mulago National Referral’, PLoS ONE, 18; 10(8). doi: 10.1371/journal.pone.0135745 26284519 PMC4540283 · DOI
  40. [45]Kotb S, Lyman M, Ismail G, Abd El Fattah M, Girgis SA, Etman A, et al. ‘ Epidemiology of Carbapenem-resistant Enterobacteriaceae in Egyptian intensive care units using National Healthcare-associated Infections Surveillance Data, 2011–2017’. Antimicrob Resist Infect Control. 2020 Jan 3; 9(1): 2. doi: 10.1186/s13756-019-0639-7 31911830 PMC6942386 · DOI
  41. [46]Gurung S, Kafle S, Dhungel B, Adhikari N, Thapa Shrestha U, Adhikari B, et al. (2020) ‘ Detection of OXA-48 Gene in Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae from Urine Samples’, Infection and Drug Resistance, 14; 13: 2311– 2321. doi: 10.2147/IDR.S259967 32765007 PMC7369300 · DOI
  42. [47]Zaidah AR, Mohammad NI, Suraiya S, Harun A. (2017) ‘ High burden of carbapenem-resistant Enterobacteriaceae (CRE) faecal carriage at a teaching hospital: Cost-effectiveness of screening in low-resource setting’, Antimicrobial Resistance and Infection Control, 6: 42. doi: 10.1186/s13756-017-0200-5 28473912 PMC5414356 · DOI
  43. [48]Villar H. E., Baserni M. N. and Jugo M. B. (2013) ‘ Faecal carriage of ESBL-producing Enterobacteriaceae and carbapenem-resistant Gram-negative bacilli in community settings’, Journal of Infection in Developing Countries, 7(8), pp. 630– 634. doi: 10.3855/jidc.2900 23949299 · DOI
  44. [49]Feglo P. K and Adu-Sarkodie Y. (2016) ‘ Antimicrobial Resistance Patterns of Extended Spectrum β-Lactamase Producing Klebsiella and E. coli Isolates from a Tertiary Hospital in Ghana’, European Scientific Journal, 12(30), pp. 174– 187. doi: 10.19044/esj.2016.v12n30p174 · DOI
  45. [50]Obeng-Nkrumah N, Labi AK, Addison NO, Labi JE, Awuah-Mensah G. (2016) Trends in paediatric and adult bloodstream infections in Ghanaian referral hospital: a retrospective study. Annals of Clinical Microbiology and Antimicrobials 15(1): 49. doi: 10.1186/s12941-016-0163-z 27539221 PMC4991019 · DOI
  46. [51]Quansah E, Amoah Barnie P, Omane Acheampong D, Obiri-Yeboah D, Odarkor Mills R, Asmah E, et al. (2019) ‘ Geographical Distribution of β -Lactam Resistance among Klebsiella spp. from Selected Health Facilities in Ghana’, Tropical Medicine and Infectious Disease, 4(3): 117. doi: 10.3390/tropicalmed4030117 31484298 PMC6789473 · DOI
  47. [52]Ranjbar R., Kelishadrokhi AF., Chehelgerdi M. (2019). ‘ Molecular characterization, serotypes and phenotypic and genotypic evaluation of antibiotic resistance of the Klebsiella pneumoniae strains isolated from different types of hospital-acquired infections. Infection and Drug Resistance. 12: 603– 611. 31114256 PMC6489651
  48. [53]Saravanan M., Ramachandran B. and Barabadi H. (2018) ‘ The prevalence and drug resistance pattern of extended-spectrum β–lactamases (ESBLs) producing Enterobacteriaceae in Africa’, Microbial Pathogenesis, 114(November 2017), pp. 180– 192. doi: 10.1016/j.micpath.2017.11.061 29196174 · DOI
  49. [54]Oliveira VD, Rubio FG, Almeida MT, Nogueira MC, Pignatari AC. (2015), “ Trends of 9,416 multidrug-resistant Gram-negative bacteria”, Rev Assoc Med Bras. 61(3): 244– 249. doi: 10.1590/1806-9282.61.03.244 26248247 · DOI
  50. [55]Codjoe FS, Donkor ES. (2017), “ Carbapenem Resistance: A Review”. Medical Sciences Journal, 6 (1): 1. doi: 10.3390/medsci6010001 29267233 PMC5872158 · DOI
  51. [56]Donkor ES, Codjoe FS. (2019) “ Methicillin-Resistant Staphylococcus aureus and Extended Spectrum Beta-lactamase Producing Enterobacteriaceae: A Therapeutic Challenge in the 21st Century”, The Open Microbiology Journal. Vol 13, 94– 100. doi: 10.2174/1874285801913010094 · DOI
  52. [57]Ministry of Health, Ghana National Drugs Programme(GNDP) (2017). Essential Medicines List, 7th Edition, pp. 1–53.
  53. [58]Hara LG, Gould I, Endimiani A, Pardo PR, Daikos G, Hsueh PR, et al. (2013) ‘ Detection, treatment, and prevention of Enterobacteriaceae: Recommendations from an International Working Group’, Journal of Chemotherapy, 25(3), pp. 129– 140. doi: 10.1179/1973947812Y.0000000062 23783137 · DOI
  54. [59]Park JW, Lee H, Park SY, Kim TH. (2019) ‘ Epidemiological, clinical and microbiological characteristics of Enterobacteriaceae bloodstream infection in the Republic of Korea’, Antimicrobial Resistance and Infection Control. Antimicrobial Resistance & Infection Control, 8(48), doi: 10.1186/s13756-019-0497-3 PMC6402157 30873279 · DOI
  55. [60]Nordmann P. and Poirel L. (2013) ‘ Strategies for identification of carbapenemase-producing Enterobacteriaceae’, J Antimicrob Chemother, 68(October 2012), pp. 487– 489. doi: 10.1093/jac/dks426 23104494 · DOI
  56. [61]Tzouvelekis L; Markogiannakis A; Psichogiou M; Tassios P; Daikos G. (2012) ‘ Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions’, Clinical Microbiology Reviews, 25(4), pp. 682– 707. doi: 10.1128/CMR.05035-11 23034326 PMC3485753 · DOI

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Authors
Dwomoh, F. P., Kotey, F. C. N., Dayie, N. T. K. D., Osei, M.-M., Amoa-Owusu, F., Bannah, V., Alzahrani, F. M., Halawani, I. F., Alzahrani, K. J., Egyir, B., & Donkor, E. S.
Affiliations
  • University of Ghana (GH)
  • Taif University (SA)
Corresponding author
Donkor, Eric S.
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2022-12-30
Volume
17
Issue
12
Pages
e0279715
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0279715
PMC
PMC9803230
OpenAlex
W4313306213
Cited by
47
References
2
Citations by year
2026: 7 · 2025: 8 · 2024: 22 · 2023: 10
FWCI
3.28
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • University of Ghana
  • Noguchi Memorial Institute for Medical Research, University of Ghana
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords
carbapenem resistance, carbapenemase-producing Escherichia coli, Klebsiella pneumoniae, multidrug resistance, blaKPC, blaNDM, blaVIM, blaOXA-48, blaIMP, modified Hodge test, modified carbapenem inactivation method, imipenem, meropenem, ertapenem
MeSH terms
Carbapenem-Resistant Enterobacteriaceae, Ertapenem, Meropenem, Anti-Bacterial Agents, Bacterial Proteins, beta-Lactamases, Cross-Sectional Studies, Escherichia coli, Ghana, Klebsiella pneumoniae, Microbial Sensitivity Tests, Imipenem, Carbapenems

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