Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

Gupta, N.; Limbago, B. M.; Patel, J. B.; Kallen, A. J.

doi:10.1093/cid/cir202

Cited by 1,033Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceEnterobacteriaceae and Cronobacter Research

Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

Gupta, N., Limbago, B. M., Patel, J. B., Kallen, A. J.·2011·Clinical Infectious Diseases

DOI 10.1093/cid/cir202

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Abstract

Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-β-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

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Antibiotic-induced disturbance can lead to the growth and expansion of pathogens within the intestine, including antibiotic-resistant pathogens.
“This disturbance can lead to the growth and expansion of pathogens within the intestine (including antibiotic-resistant pathogens), where these pathogens can exploit the absence of competitors and the nutrient-enriched gut environment.”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [31]
Antibiotic treatment - especially treatment with broad-spectrum antibiotics - kills members of the gut microbiota and disrupts colonization resistance.
“Antibiotic treatment – especially treatment with broad-spectrum antibiotics – kills members of the gut microbiota and disrupts colonization resistance (Fig. 1).”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [31]
Antibiotic treatment promotes intestinal colonization (and even domination) by pathogens such as Clostridioides difficile, carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant Enterococcus (VRE).
“This promotes intestinal colonization (and even domination) by pathogens such as Clostridioides difficile , carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant Enterococcus (VRE) [30–32].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [31]

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Authors: Gupta, N., Limbago, B. M., Patel, J. B., & Kallen, A. J.
Affiliations: Centers for Disease Control and Prevention (US)
ORCID: Gupta, N.
Patel, J. B.
Kallen, A. J.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2011-06-07
Volume: 53
Issue: 1
Pages: 60-67
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/cir202
OpenAlex: W2113898837
Cited by: 1,033
References: 48
Citations by year: 2026: 20 · 2025: 32 · 2024: 36 · 2023: 54 · 2022: 60 · 2021: 68 · 2020: 78 · 2019: 96 · 2018: 80 · 2017: 99 · 2016: 82 · 2015: 92 · 2014: 97 · 2013: 77 · 2012: 54
FWCI: 4.10
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: Kimberly-Clark
Centers for Disease Control and Prevention
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
Keywords: carbapenem-resistant Enterobacteriaceae, KPC, New Delhi metallo-beta-lactamase, mobile genetic elements, infection control, antimicrobial resistance, United States
MeSH terms: Bacterial Proteins, beta-Lactamases, Enterobacteriaceae, Enterobacteriaceae Infections, Humans, Carbapenems, Drug Resistance, Bacterial

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