The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria
Open accessAbstract
The variant surface antigens expressed on Plasmodium falciparum-infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every parasite genome. Here we use semi-conserved regions within short var gene sequence "tags" to make direct comparisons of var gene expression in 12 clinical parasite isolates from Kenyan children. A total of 1,746 var clones were sequenced from genomic and cDNA and assigned to one of six sequence groups using specific sequence features. The results show the following. (1) The relative numbers of genomic clones falling in each of the sequence groups was similar between parasite isolates and corresponded well with the numbers of genes found in the genome of a single, fully sequenced parasite isolate. In contrast, the relative numbers of cDNA clones falling in each group varied considerably between isolates. (2) Expression of sequences belonging to a relatively conserved group was negatively associated with the repertoire of variant surface antigen antibodies carried by the infected child at the time of disease, whereas expression of sequences belonging to another group was associated with the parasite "rosetting" phenotype, a well established virulence determinant. Our results suggest that information on the state of the host-parasite relationship in vivo can be provided by measurements of the differential expression of different var groups, and need only be defined by short stretches of sequence data.
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Self-citationBull, P. C., Lowe, B. S., Kortok, M., Molyneux, C. S., Newbold, C. I., & Marsh, K. (1998) · Nature Medicine · doi:10.1038/nm0398-358 · Cited by 645
Self-citationRapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
Self-citationNielsen, M. A., Staalsoe, T., Kurtzhals, J. A. L., Goka, B. Q., Dodoo, D., Alifrangis, M., Theander, T. G., Akanmori, B. D., & Hviid, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3444 · Cited by 207
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Structure and inference in annotated networks
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Lavstsen, T., Turner, L., Saguti, F., Magistrado, P., Rask, T. S., Jespersen, J. S., Wang, C. W., Berger, S. S., Baraka, V., Marquard, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120455109 · Cited by 269
Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
Barry, A. E., Leliwa-Sytek, A., Tavul, L., Imrie, H., Migot-Nabias, F., Brown, S. M., McVean, G. A. V., & Day, K. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030034 · Cited by 199
Trimnell, A. R., Kraemer, S. M., Mukherjee, S., Phippard, D. J., Janes, J. H., Flamoe, E., Su, X.-Z., Awadalla, P., & Smith, J. D. (2006) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2006.03.012 · Cited by 165
Evolutionary analysis of the most polymorphic gene family in falciparum malaria
Otto, T. D., Assefa, S. A., Böhme, U., Sanders, M. J., Kwiatkowski, D. P., Pf3k consortium, Berriman, M., & Newbold, C. (2019) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15590.1 · Cited by 90
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Metadata
- Authors
- Bull, P. C., Berriman, M., Kyes, S., Quail, M. A., Hall, N., Kortok, M. M., Marsh, K., & Newbold, C. I.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-11-18
- Volume
- 1
- Issue
- 3
- Pages
- e26
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2040754029
- Cited by
- 189
- References
- 5
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bull, P. C., Berriman, M., Kyes, S., Quail, M. A., Hall, N., Kortok, M. M., Marsh, K., & Newbold, C. I. (2005). Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.0010026
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