The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Suppression of Plant Resistance Gene-Based Immunity by a Fungal Effector
Open accessAbstract
The innate immune system of plants consists of two layers. The first layer, called basal resistance, governs recognition of conserved microbial molecules and fends off most attempted invasions. The second layer is based on Resistance (R) genes that mediate recognition of effectors, proteins secreted by pathogens to suppress or evade basal resistance. Here, we show that a plant-pathogenic fungus secretes an effector that can both trigger and suppress R gene-based immunity. This effector, Avr1, is secreted by the xylem-invading fungus Fusarium oxysporum f.sp. lycopersici (Fol) and triggers disease resistance when the host plant, tomato, carries a matching R gene (I or I-1). At the same time, Avr1 suppresses the protective effect of two other R genes, I-2 and I-3. Based on these observations, we tentatively reconstruct the evolutionary arms race that has taken place between tomato R genes and effectors of Fol. This molecular analysis has revealed a hitherto unpredicted strategy for durable disease control based on resistance gene combinations.
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Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
Chisholm, S. T., Coaker, G., Day, B., & Staskawicz, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.008 · Cited by 2,957
Fusarium oxysporum : exploring the molecular arsenal of a vascular wilt fungus
Pietro, A. D., Madrid, M. P., Caracuel, Z., Delgado‐Jarana, J., & Roncero, M. I. G. (2003) · Molecular Plant Pathology · doi:10.1046/j.1364-3703.2003.00180.x · Cited by 464
Cited by
Fungal endophytes: modifiers of plant disease
Busby, P. E., Ridout, M., & Newcombe, G. (2016) · Plant Molecular Biology · doi:10.1007/s11103-015-0412-0 · Cited by 445
The role of chitin detection in plant–pathogen interactions
Kombrink, A., Sánchez-Vallet, A., & Thomma, B. P. H. J. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.07.010 · Cited by 121
(2024) · doi:10.7554/elife.89280.3 · Cited by 64
Rocafort, M., Bowen, J. K., Hassing, B., Cox, M. P., McGreal, B., de la Rosa, S., Plummer, K. M., Bradshaw, R. E., & Mesarich, C. H. (2022) · BMC Biology · doi:10.1186/s12915-022-01442-9 · Cited by 52
A pathogen effector FOLD diversified in symbiotic fungi
Teulet, A., Quan, C., Evangelisti, E., Wanke, A., Yang, W., & Schornack, S. (2023) · New Phytologist · doi:10.1111/nph.18996 · Cited by 40
Metadata
- Authors
- Houterman, P. M., Cornelissen, B. J. C., & Rep, M.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-05-09
- Volume
- 4
- Issue
- 5
- Pages
- e1000061
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2040305822
- Cited by
- 365
- References
- 3
- FWCI
- 19.28
- Type
- journal article
- Language
- en
- Open access
- gold
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