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The Aedes aegypti Toll Pathway Controls Dengue Virus Infection
Open accessAbstract
Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans. To date, the features of insects' innate immune defenses against viruses have mainly been studied in the fruit fly Drosophila melanogaster, which appears to utilize different immune pathways against different types of viruses, in addition to an RNA interference-based defense system. We have used the recently released whole-genome sequence of the Ae. aegypti mosquito, in combination with high-throughput gene expression and RNA interference (RNAi)-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments. We have further addressed the impact of the mosquito's endogenous microbial flora on virus infection. Our findings indicate a significant role for the Toll pathway in regulating resistance to dengue virus, as indicated by an infection-responsive regulation and functional assessment of several Toll pathway-associated genes. We have also shown that the mosquito's natural microbiota play a role in modulating the dengue virus infection, possibly through basal-level stimulation of the Toll immune pathway.
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Cites
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
Cited by
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Biochemistry and Molecular Biology of Flaviviruses
Barrows, N. J., Campos, R. K., Liao, K.-C., Prasanth, K. R., Soto-Acosta, R., Yeh, S.-C., Schott-Lerner, G., Pompon, J., Sessions, O. M., Bradrick, S. S., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00719 · Cited by 341
Paradkar, P. N., Trinidad, L., Voysey, R., Duchemin, J.-B., & Walker, P. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205231109 · Cited by 329
Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts
Lobo, F. P., Mota, B. E. F., Pena, S. D. J., Azevedo, V., Macedo, A. M., Tauch, A., Machado, C. R., & Franco, G. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006282 · Cited by 191
Metadata
- Authors
- Xi, Z., Ramirez, J. L., & Dimopoulos, G.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-07-04
- Volume
- 4
- Issue
- 7
- Pages
- e1000098
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2030551855
- Cited by
- 930
- References
- 1
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xi, Z., Ramirez, J. L., & Dimopoulos, G. (2008). The Aedes aegypti Toll Pathway Controls Dengue Virus Infection. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1000098
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
