The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway
Open accessAbstract
Although West Nile virus (WNV) and other arthropod-borne viruses are a major public health problem, the mechanisms of antiviral immunity in mosquitoes are poorly understood. Dicer-2, responsible for the RNAi-mediated response through the C-terminal RNase-III domain, also contains an N-terminal DExD/H-box helicase domain similar to mammalian RIG-I/MDA5 which, in Drosophila , was found to be required for activation of an antiviral gene, Vago . Here we show that the Culex orthologue of Vago ( Cx Vago) is up-regulated in response to WNV infection in a Dicer-2–dependent manner. Further, our data show that Cx Vago is a secreted peptide that restricts WNV infection by activation of the Jak-STAT pathway. Thus, Vago appears to function as an IFN-like antiviral cytokine in mosquitoes.
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Cites
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Cited by
Insect immunology and hematopoiesis
Hillyer, J. F. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.12.006 · Cited by 561
Biochemistry and Molecular Biology of Flaviviruses
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Metadata
- Authors
- Paradkar, P. N., Trinidad, L., Voysey, R., Duchemin, J.-B., & Walker, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-10
- Volume
- 109
- Issue
- 46
- Pages
- 18915-18920
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003859935
- Cited by
- 329
- References
- 31
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Paradkar, P. N., Trinidad, L., Voysey, R., Duchemin, J.-B., & Walker, P. J. (2012). Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1205231109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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