The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection
Open accessAbstract
Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.
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CD 4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
Okoye, A. A., & Picker, L. J. (2013) · Immunological Reviews · doi:10.1111/imr.12066 · Cited by 567
Microbial Translocation Across the GI Tract
Brenchley, J. M., & Douek, D. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075001 · Cited by 496
Jacquelin, B., Mayau, V., Targat, B., Liovat, A.-S., Kunkel, D., Petitjean, G., Dillies, M.-A., Roques, P., Butor, C., Silvestri, G., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40093 · Cited by 481
Estes, J. D., Harris, L. D., Klatt, N. R., Tabb, B., Pittaluga, S., Paiardini, M., Barclay, G. R., Smedley, J., Pung, R., Oliveira, K. M., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001052 · Cited by 477
Self-citation
Metadata
- Authors
- Favre, D., Lederer, S., Kanwar, B., Ma, Z.-M., Proll, S., Kasakow, Z., Mold, J., Swainson, L., Barbour, J. D., Baskin, C. R., Palermo, R., Pandrea, I., Miller, C. J., Katze, M. G., & McCune, J. M.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-02-13
- Volume
- 5
- Issue
- 2
- Pages
- e1000295
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W1994287107
- Cited by
- 405
- References
- 65
- FWCI
- 17.96
- Type
- journal article
- Language
- en
- Open access
- gold
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- Favre, D., Lederer, S., Kanwar, B., Ma, Z.-M., Proll, S., Kasakow, Z., Mold, J., Swainson, L., Barbour, J. D., Baskin, C. R., Palermo, R., Pandrea, I., Miller, C. J., Katze, M. G., & McCune, J. M. (2009). Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1000295
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