Microbial Translocation Across the GI Tract

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

The Pathophysiology and Treatment of Sepsis

Hotchkiss, R. S., & Karl, I. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021333 · Cited by 4,098 · see citing works

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559 · see citing works

Hepatogastroenterology

Chen, L., Li, N., & Ye, H. (2012) · Hepatogastroenterology · doi:10.5754/hge12469 · Cited by 3,199 · see citing works

Inflammatory Bowel Disease

Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183 · see citing works

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works

The gut flora as a forgotten organ

O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791 · see citing works

Bone Marrow Transplant

Ford, R. C., & Eisenberg, S. (1990) · Nursing Clinics of North America · doi:10.1016/s0029-6465(22)02934-6 · Cited by 2,734 · see citing works

Interleukin-17 Family Members and Inflammation

Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371 · see citing works

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330 · see citing works

Phenotypic and functional features of human Th17 cells

Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works

CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

Brenchley, J. M., Schacker, T. W., Ruff, L. E., Price, D. A., Taylor, J. H., Beilman, G. J., Nguyen, P. L., Khoruts, A., Larson, M. C., Haase, A. T., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040874 · Cited by 1,836 · see citing works

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828 · see citing works

. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.

Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617 · see citing works

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584 · see citing works

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442 · cited 1× · see citing works

Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection

Veazey, R. S., DeMaria, M. A., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998) · Science · doi:10.1126/science.280.5362.427 · Cited by 1,404 · see citing works

IL-22 Increases the Innate Immunity of Tissues

Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,362 · see citing works

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288 · see citing works

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Mattapallil, J. J., Douek, D. C., Hill, B. J., Nishimura, Y., Martin, M. A., & Roederer, M. (2005) · Nature · doi:10.1038/nature03501 · Cited by 1,269 · see citing works

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

Aujla, S. J., Chan, Y. R., Zheng, M., Fei, M., Askew, D. J., Pociask, D. A., Reinhart, T. A., McAllister, F. M., Edeal, J., Gaus, K., et al. (2008) · Nature Medicine · doi:10.1038/nm1710 · Cited by 1,162 · see citing works

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works

Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract

Mehandru, S., Poles, M. A., Tenner‐Racz, K., Horowitz, A., Hurley, A., Hogan, C., Boden, D., Rácz, P., & Markowitz, M. H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041196 · Cited by 1,143 · see citing works

. Plasma levels of soluble CD14 independently predict mortality in HIV infection.

Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq118 · Cited by 1,106 · see citing works

I nterleukin -10 and R elated C ytokines and R eceptors

Pestka, S., Krause, C. D., Sarkar, D., Walter, M. R., Shi, Y., & Fisher, P. B. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104622 · Cited by 1,097 · see citing works

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

Ziegler, E. J., McCutchan, J. A., Fierer, J., Glauser, M. P., SADOFF, J. C., Douglas, H., & Braude, A. I. (1982) · New England Journal of Medicine · doi:10.1056/nejm198211113072001 · Cited by 1,044 · see citing works

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082683 · Cited by 1,043 · see citing works

Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage

Giorgi, J. V., Hultin, L. E., McKeating, J. A., Johnson, T. D., Owens, B. M., Jacobson, L. P., Shih, R., Lewis, J., Wiley, D. J., Phair, J. P., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314660 · Cited by 1,032 · see citing works

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

Sugimoto, K., Ogawa, A., Mizoguchi, E., Shimomura, Y., Andoh, A., Bhan, A. K., Blumberg, R. S., Xavier, R. J., & Mizoguchi, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33194 · Cited by 1,016 · see citing works

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 997 · see citing works

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

Migueles, S. A., Sabbaghian, M. S., Shupert, W. L., Bettinotti, M. P., Marincola, F. M., Martino, L., Hallahan, C. W., Selig, S. M., Schwartz, D. H., Sullivan, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050567397 · Cited by 995 · see citing works

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., Desimone, C., Song, X.-Y., & Diehl, A. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50048 · Cited by 930 · see citing works

Bacterial contamination of pancreatic necrosis

Beger, H. G., Bittner, R., Block, S., & Büchler, M. W. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90579-2 · Cited by 925 · see citing works

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

Smythies, L. E., Sellers, M. T., Clements, R. H., Mosteller‐Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M., & Smith, P. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200519229 · Cited by 924 · see citing works

Severe CD4⁺T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

Guadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S. (2003) · Journal of Virology · doi:10.1128/jvi.77.21.11708-11717.2003 · Cited by 866 · see citing works

Requirement of Interleukin‐17A for Systemic Anti– <i>Candida albicans</i> Host Defense in Mice

Huang, W., Na, L., Fidel, P. L., & Schwarzenberger, P. (2004) · The Journal of Infectious Diseases · doi:10.1086/422329 · Cited by 859 · see citing works

T Cell Activation Is Associated with Lower CD4+T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy

Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B. M., Hagos, E., Lampiris, H. W., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852 · see citing works

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

Yang, S. Q., Lin, H. Z., Lane, M. D., Clemens, M. G., & Diehl, A. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2557 · Cited by 808 · see citing works

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

Deeks, S. G., Ramirez, C. M., Liu, L., Guo, H., Gascon, R., Narváez, A. B., Hunt, P. W., Martin, J. N., Kahn, J. S., Levy, J. A., et al. (2004) · Blood · doi:10.1182/blood-2003-09-3333 · Cited by 803 · see citing works

Diversity of human colonic butyrate‐producing bacteria revealed by analysis of the butyryl‐CoA:acetate CoA‐transferase gene

Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762 · see citing works

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology · doi:10.1038/ni.1736 · Cited by 756 · see citing works

VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743 · see citing works

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

Takatori, H., Kanno, Y., Watford, W. T., Tato, C. M., Weiss, G. E., Ivanov, I. I., Littman, D. R., & O’Shea, J. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072713 · Cited by 737 · see citing works

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

Walker, A. W., Sanderson, J. D., Churcher, C. M., Parkes, G. C., Hudspith, B. N., Rayment, N. B., Brostoff, J., Parkhill, J., Dougan, G., & Petrovska, L. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-7 · Cited by 727 · see citing works

The Liver Sieve: Considerations Concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse

Wisse, E., Zanger, R. D., Charels, K., Smissen, P. V. D., & McCuskey, R. S. (1985) · Hepatology · doi:10.1002/hep.1840050427 · Cited by 712 · see citing works

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor- viral RNA interactions

Beignon, A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26032 · Cited by 674 · see citing works

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

Brenchley, J. M., Paiardini, M., Knox, K. S., Asher, A. I., Cervasi, B., Asher, T. E., Scheinberg, P., Price, D. A., Hage, C. A., Kholi, L. M., et al. (2008) · Blood · doi:10.1182/blood-2008-05-159301 · Cited by 647 · see citing works

Relationship between T Cell Activation and CD4 + T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

Hunt, P. W., Brenchley, J. M., Sinclair, E., McCune, J. M., Roland, M. E., Page, K. A., Hsue, P. Y., Emu, B., Krone, M., Lampiris, H. W., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/524143 · Cited by 639 · see citing works

Interleukin 22 (IL‐22) plays a protective role in T cell‐mediated murine hepatitis: IL‐22 is a survival factor for hepatocytes via STAT3 activation

Radaeva, S., Sun, R., Pan, H., Hong, F., & Gao, B. (2004) · Hepatology · doi:10.1002/hep.20184 · Cited by 638 · see citing works

The structure and function of human IgA

Kerr, M. A. (1990) · Biochemical Journal · doi:10.1042/bj2710285 · Cited by 599 · see citing works

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

Meier, A., Chang, J. J., Chan, E. S., Pollard, R. B., Sidhu, H. K., Kulkarni, S., Wen, F., Lindsay, R. J., Orellana, L., Mildvan, D., et al. (2009) · Nature Medicine · doi:10.1038/nm.2004 · Cited by 596 · see citing works

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

Jiang, W., Lederman, M. M., Hunt, P. W., Sieg, S. F., Haley, K. P., Rodriguez, B. A., LANDAY, A. L., Martin, J. N., Sinclair, E., Asher, A. I., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/597476 · Cited by 591 · see citing works

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., & Honjo, T. (2002) · Science · doi:10.1126/science.1077336 · Cited by 590 · see citing works

Enteropathy Associated with the Acquired Immunodeficiency Syndrome

Kotler, D. P., GAETZ, H. P., LANGE, M., KLEIN, E. B., & HOLT, P. R. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-4-421 · Cited by 590 · see citing works

Selective IgA Deficiency

Yel, L. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9357-x · Cited by 582 · see citing works

HIV disease: fallout from a mucosal catastrophe?

Brenchley, J. M., Price, D. A., & Douek, D. C. (2006) · Nature Immunology · doi:10.1038/ni1316 · Cited by 579 · see citing works

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A., & Artis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.009 · Cited by 573 · see citing works

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

Sawa, S., Lochner, M., Satoh‐Takayama, N., Dulauroy, S., Berard, M., Kleinschek, M. A., Cua, D., Santo, J. P. D., & Eberl, G. (2011) · Nature Immunology · doi:10.1038/ni.2002 · Cited by 568 · see citing works

Intestinal Microbiota of 6‐week‐old Infants Across Europe: Geographic Influence Beyond Delivery Mode, Breast‐feeding, and Antibiotics

Fallani, M., Young, D., Scott, J. A., Norin, E. L., Amarri, S., Adam, R., Aguilera, J., Khanna, S., Gil, Á., Edwards, C. A., et al. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d1b11e · Cited by 559 · see citing works

Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess

Bode, C., Kugler, V., & Bode, J. C. (1987) · Journal of Hepatology · doi:10.1016/s0168-8278(87)80003-x · Cited by 529 · see citing works

C-Reactive Protein as a Marker for Inflammatory Bowel Disease

Vermeire, S., Assche, G. V., & Rutgeerts, P. J. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200409000-00026 · Cited by 514 · see citing works

Oral use of <i>Lactobacillus rhamnosus</i> GR-1 and <i>L. fermentum</i> RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women

Reid, G., Charbonneau, D., Erb, J., Kochanowski, B., Beuerman, D., Poehner, R., & Bruce, A. W. (2003) · FEMS Immunology &amp; Medical Microbiology · doi:10.1016/s0928-8244(02)00465-0 · Cited by 514 · see citing works

The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to-Moderately Active Ulcerative Colitis

Sood, A., Midha, V., Makharia, G. K., Ahuja, V., Singal, D., Goswami, P., & Tandon, R. K. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.07.016 · Cited by 513 · see citing works

Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

Ancuta, P., Kamat, A., Kunstman, K. J., Kim, E.-Y., Autissier, P., Wurcel, A., Zaman, T., Stone, D., Mefford, M., Morgello, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002516 · Cited by 499 · see citing works

Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells

Prasad, S. B., Mingrino, R., Kaukinen, K., Hayes, K. L., Powell, R. M., MacDonald, T. T., & Collins, J. E. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700316 · Cited by 493 · see citing works

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

Estes, J. D., Harris, L. D., Klatt, N. R., Tabb, B., Pittaluga, S., Paiardini, M., Barclay, G. R., Smedley, J. V., Pung, R., Oliveira, K. M., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001052 · Cited by 477 · see citing works

Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis

Zocco, M. A., Verme, L. Z. D., Cremonini, F., Piscaglia, A. C., Nista, E. C., Candelli, M., Novi, M., Rigante, D., Cazzato, I. A., Ojetti, V., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02927.x · Cited by 472 · see citing works

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works

Probiotics Restore Bowel Flora and Improve Liver Enzymes in Human Alcohol-Induced Liver Injury: A Pilot Study

Kirpich, I., Solovieva, N., Leikhter, S., Shidakova, N. A., Lebedeva, O. V., Sidorov, P., Bazhukova, T. A., Soloviev, A., Barve, S., McClain, C., et al. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.08.006 · Cited by 464 · see citing works

Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay

Fukui, H., Brauner, B., Bode, J. C., & Bode, C. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90933-3 · Cited by 461 · see citing works

The role of the gut microbiota in nonalcoholic fatty liver disease

Abu-Shanab, A., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2010.172 · Cited by 457 · see citing works

Animal Models of Steatosis

Koteish, A. A., & Diehl, A. M. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-12932 · Cited by 447 · see citing works

The role of the intestinal microbiota in the development of atopic disorders

Penders, J., Stobberingh, E. E., van den Brandt, P. A., & Thijs, C. T. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01462.x · Cited by 435 · see citing works

THE LEAKY GUT OF ALCOHOLISM: POSSIBLE ROUTE OF ENTRY FOR TOXIC COMPOUNDS

Bjarnason, I., Ward, K., & Peters, T. B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92109-3 · Cited by 432 · see citing works

Graft-versus-Host Disease and Survival in Patients with Aplastic Anemia Treated by Marrow Grafts from HLA-Identical Siblings

Storb, R. F., Prentice, R. L., Buckner, C. D., Clift, R. A., Appelbaum, F. R., Deeg, J., Doney, K., Hansen, J. A., Mason, M. W., Sanders, J. E., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302103080602 · Cited by 431 · see citing works

Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes

Bažil, V., & Strominger, J. L. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.5.1567 · Cited by 430 · see citing works

Is Lactobacillus GG helpful in children with Crohn’s disease? Results of a preliminary, open-label study

Gupta, P., Andrew, H., Kirschner, B. S., & Guandalini, S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200010000-00024 · Cited by 429 · see citing works

Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis

Lumsden, A. B., Henderson, M. J., & Kutner, M. H. (1988) · Hepatology · doi:10.1002/hep.1840080207 · Cited by 427 · see citing works

IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways

Kao, C.-Y., Chen, Y., Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R. W., & Wu, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3482 · Cited by 424 · see citing works

Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80.

Lee, S. H., Starkey, P. M., & Gordon, S. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.161.3.475 · Cited by 423 · see citing works

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

Clayburgh, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24970 · Cited by 419 · see citing works

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

Johansen, F., Pekna, M., Norderhaug, I. N., Haneberg, B., Hietala, M. A., Krajči, P., Betsholtz, C., & Brandtzæg, P. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.915 · Cited by 417 · see citing works

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

Favre, D., Lederer, S., Kanwar, B., Ma, Z.-M., Proll, S. C., Kasakow, Z., Mold, J. E., Swainson, L. A., Barbour, J. D., Baskin, C. R., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000295 · Cited by 403 · see citing works

Tight junctions as targets of infectious agents

Guttman, J. A., & Finlay, B. B. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.028 · Cited by 398 · see citing works

Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases.

Sartor, R. B. (1997) · PubMed · Cited by 395 · see citing works

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

Zolotarevsky, Y., Hecht, G. A., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J., & Turner, J. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34235 · Cited by 385 · see citing works

Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge

Knöll, P., Schlaak, J., Uhrig, A., Kempf, P., Büschenfelde, K. M. Z., & Gerken, G. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80433-1 · Cited by 384 · see citing works

Effect of alcohol consumption on the gut.

Bode, C., & Christian Bode, J. (2003) · Best Practice &amp; Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00034-9 · Cited by 379 · see citing works

Early increase in intestinal permeability in patients with severe acute pancreatitis: Correlation with endotoxemia, organ failure, and mortality

Ammori, B., Leeder, P., King, R., Barclay, G., Martin, I., Larvin, M., & Mcmahon, M. (1999) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(99)80067-5 · Cited by 346 · see citing works

Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex‐Germ‐Free Mouse

Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., & Setoyama, H. (1995) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1995.tb02242.x · Cited by 346 · see citing works

LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.

Lamping, N., Dettmer, R., Schröder, N. W. J., Pfeil, D., Hallatschek, W., Burger, R., & Schumann, R. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2338 · Cited by 345 · see citing works

Regional specialization in the mucosal immune system: what happens in the microcompartments?

Brandtzæg, P., Bækkevold, E. S., Farstad, I. N., Jahnsen, F. L., Johansen, F., Nilsen, E. M., & Yamanaka, T. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01413-3 · Cited by 342 · see citing works

Inflammatory bowel disease

Teitelbaum, D. H., & Coran, A. G. (2006) · CRC Press eBooks · doi:10.1201/b13237-67 · Cited by 341 · see citing works

Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease.

Cooke, K. R., Hill, G. R., Crawford, J. M., Bungard, D., Brinson, Y. S., Delmonte, J., & Ferrara, J. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4285 · Cited by 336 · see citing works

Probiotics inhibit nuclear factor-κB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition

Petrof, E. O., Kojima, K., Ropeleski, M. J., Musch, M. W., Tao, Y., Simone, C. D., & Chang, E. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.001 · Cited by 330 · see citing works

Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

De Palma, G., Nadal, I., Medina, M., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-63 · Cited by 330 · see citing works

Intestinal Macrophages Lack CD14 and CD89 and Consequently Are Down-Regulated for LPS- and IgA-Mediated Activities

Smith, P. D., Smythies, L. E., Mosteller‐Barnum, M., Sibley, D. A., Russell, M. W., Merger, M., Sellers, M. T., Orenstein, J. M., Shimada, T., Graham, M. F., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2651 · Cited by 327 · see citing works

C(−260)→T Polymorphism in the Promoter of the CD14 Monocyte Receptor Gene as a Risk Factor for Myocardial Infarction

Hubacek, J. A., Pitha, J. V., Škodová, Z., Stanĕk, V., & Poledne, R. (1999) · Circulation · doi:10.1161/01.cir.99.25.3218 · Cited by 327 · see citing works

Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection

Sandler, N. G., Koh, C., Roque, A., Eccleston, J. L., Siegel, R. B., Demino, M., Kleiner, D. E., Deeks, S. G., Liang, T. J., Heller, T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.063 · Cited by 307 · see citing works

Jejunal microflora in patients with chronic alcohol abuse.

Jc, B., Bode, C., Heidelbach, R., Hk, D., & Ga, M. (1984) · PubMed · Cited by 303 · see citing works

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

Marchetti, G. C., Bellistrì, G. M., Borghi, E., Tincati, C., Ferramosca, S., Francesca, M. L., Morace, G., Gori, A., & Monforte, A. D. (2008) · AIDS · doi:10.1097/qad.0b013e3283112d29 · Cited by 296 · see citing works

The host–microbe interface within the gut

Shanahan, F. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2002.0342 · Cited by 296 · see citing works

Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Mehandru, S., Poles, M. A., Tenner‐Racz, K., Jean-Pierre, P., Manuelli, V., Lopez, P., Shet, A., Low, A., Mohri, H., Boden, D., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030484 · Cited by 287 · see citing works

Human Immunodeficiency Virus-Related Microbial Translocation and Progression of Hepatitis C

Balagopal, A., Philp, F. H., Astemborski, J. A., Block, T. M., Mehta, A. S., Long, R. E., Kirk, G. D., Mehta, S. H., Cox, A. L., Thomas, D. L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.022 · Cited by 282 · see citing works

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

Vereecke, L., Sze, M., Guire, C. M., Rogiers, B., Chu, Y., Schmidt‐Supprian, M., Pasparakis, M., Beyaert, R., & Loo, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092474 · Cited by 278 · see citing works

Paneth cell differentiation in the developing intestine of normal and transgenic mice.

Bry, L., Falk, P., Huttner, K. M., Ouellette, A. J., Midtvedt, T., & Gordon, J. I. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10335 · Cited by 273 · see citing works

Lipopolysaccharide-Binding Protein Plasma Levels and Liver TNF-Alpha Gene Expression in Obese Patients: Evidence for the Potential Role of Endotoxin in the Pathogenesis of Non-Alcoholic Steatohepatitis

Guerra-Ruiz, A. R., Casafont, F., Crespo, J., Cayón, A., Mayorga, M. M., Estébanez, Á., Fernández-Escalante, J. C., & Pons‐Romero, F. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9243-7 · Cited by 268 · see citing works

Modulatory effects of sCD14 and LBP on LPS-host cell interactions

Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x46565 · Cited by 268 · see citing works

Differentiation and self-renewal in the mouse gastrointestinal epithelium

Gordon, J. I., & Hermiston, M. L. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90047-7 · Cited by 258 · see citing works

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

Lochner, M., Ohnmacht, C., Presley, L. L., Bruhns, P., Si‐Tahar, M., Sawa, S., & Eberl, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100052 · Cited by 254 · see citing works

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

Schreiber, S., Nikolaus, S., Hampe, J., Hämling, J., Koop, I., Groessner, B., Lochs, H., & Raedler, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)03339-x · Cited by 252 · see citing works

Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection

Arnsten, J. H., Freeman, R., Howard, A. A., Floris-Moore, M., Lo, Y., & Klein, R. S. (2007) · AIDS · doi:10.1097/qad.0b013e3280148c05 · Cited by 251 · see citing works

Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection

Guadalupe, M., Sankaran, S., George, M. D., Reay, E., Verhoeven, D. E., Shacklett, B. L., Flamm, J., Wegelin, J. A., Prindiville, T. P., & Dandekar, S. (2006) · Journal of Virology · doi:10.1128/jvi.00120-06 · Cited by 248 · see citing works

Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance

Caradonna, L., Amati, L., Magrone, T., Pellegrino, N. M., Jirillo, E., & Caccavo, D. (2000) · Journal of Endotoxin Research · doi:10.1177/09680519000060030101 · Cited by 247 · see citing works

Predictive Value of Immunologic and Virologic Markers After Long or Short Duration of HIV-1 Infection

Giorgi, J. V., Lyles, R. H., Matud, J. L., Yamashita, T. E., Mellors, J. W., Hultin, L. E., Jamieson, B. D., Margolick, J. B., Rinaldo, C. R., Phair, J., et al. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200204010-00004 · Cited by 246 · see citing works

CD4+ T Cells Mediate Abscess Formation in Intra-abdominal Sepsis by an IL-17-Dependent Mechanism

Chung, D. R., Kasper, D. L., Panzo, R. J., Chtinis, T., Grusby, M. J., Sayegh, M. H., & Tzianabos, A. O. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.1958 · Cited by 243 · see citing works

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

Cecchinato, V., Trindade, C. J., Laurence, A. D. J., Héraud, J., Brenchley, J. M., Ferrari, M. G., Zaffiri, L., Tryniszewska, E. A., Tsai, W. P., Vaccari, M., et al. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.14 · Cited by 242 · see citing works

Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human Immunodeficiency Virus Pathogenesis

Gori, A., Tincati, C., Rizzardini, G., Torti, C., Quirino, T., Haarman, M., Amor, K. B., van Schaik, J., Vriesema, A. J. M., Knol, J., et al. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01729-07 · Cited by 232 · see citing works

Modulatory effects of sCD14 and LBP on LPS-host cell interactions

Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1177/09680519050110040701 · Cited by 231 · see citing works

Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease

Pastor, Ó., López–Sanromán, A., Albéniz, E., Martínez, A. D. L. H., Sevillano, E. R., & Albillos, A. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20019 · Cited by 229 · see citing works

Significance of systemic endotoxaemia in inflammatory bowel disease.

Gardiner, K. R., HALLIDAY, M. I., Barclay, G. R., Milne, L., Brown, D. J., Stephens, S., Maxwell, R., & Rowlands, B. J. (1995) · Gut · doi:10.1136/gut.36.6.897 · Cited by 226 · see citing works

Intestinal macrophages: unique effector cells of the innate immune system

Smith, P. D., Ochsenbauer‐Jambor, C., & Smythies, L. E. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00288.x · Cited by 225 · see citing works

Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2

Brubaker, P. L., & Anini, Y. (2003) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y03-107 · Cited by 220 · see citing works

Dietary Composition and Nonalcoholic Fatty Liver Disease

Solga, S. F., Alkhuraishe, A. R., Clark, J. M., TORBENSON, M., Greenwald, A., Diehl, A. M., & Magnuson, T. H. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000043367.69470.b7 · Cited by 214 · see citing works

Persistent Microbial Translocation and Immune Activation in HIV‐1–Infected South Africans Receiving Combination Antiretroviral Therapy

Cassol, E., Malfeld, S., Mahasha, P. W., der Merwe, V., Cassol, S. A., Seebregts, C. J., Alfano, M., Poli, G., & Rossouw, T. M. (2010) · The Journal of Infectious Diseases · doi:10.1086/655229 · Cited by 213 · see citing works

Role of the faecal stream in the maintenance of Crohn's colitis.

Harper, P. H., Lee, E. C., Kettlewell, M. G. W., Bennett, M. K., & Jewell, D. P. (1985) · Gut · doi:10.1136/gut.26.3.279 · Cited by 202 · see citing works

Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function

Hopkins, A. M., Walsh, S. V., Verkade, P., Boquet, P., & Nusrat, A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00300 · Cited by 202 · see citing works

Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1

Wu, Z., Nybom, P., & Magnusson, K.-E. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00025.x · Cited by 195 · see citing works

Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses

Macal, M., Sankaran, S., Chun, T.-W., Reay, E., Flamm, J., Prindiville, T., & Dandekar, S. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.35 · Cited by 195 · see citing works

Modulation of tight junction structure and function by cytokines

Walsh, S. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00048-x · Cited by 188 · see citing works

Biostructure of Fecal Microbiota in Healthy Subjects and Patients With Chronic Idiopathic Diarrhea

Swidsinski, A., Loening–Baucke, V., Verstraelen, H., Osowska, S., & Doerffel, Y. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.017 · Cited by 178 · see citing works

Structural and functional changes of the duodenum in human norovirus infection

Troeger, H., Loddenkemper, C., Schneider, T., Schreier, E., Epple, H.-J., Zeitz, M., Fromm, M., & Schulzke, J.-D. (2008) · Gut · doi:10.1136/gut.2008.160150 · Cited by 175 · see citing works

Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo‐controlled trial with rifaximin

Prantera, C., Lochs, H. H., Campieri, M., Scribano, M. L., Sturniolo, G. C., CASTIGLIONE, F., & Cottone, M. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02879.x · Cited by 163 · see citing works

Gut-liver axis: a new point of attack to treat chronic liver damage?

Loguercio, C., Simone, T. D., Federico, A. D., Terracciano, F., Tuccillo, C., CHICCO, M. D., Cartenı̀, M., & Blanco, C. D. V. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05942.x · Cited by 155 · see citing works

Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea

Sharpstone, D., Neild, P., Crane, R., Taylor, C. M., Hodgson, C., Sherwood, R., Gazzard, B., & Bjarnason, I. (1999) · Gut · doi:10.1136/gut.45.1.70 · Cited by 155 · see citing works

Definition of sepsis

Matot, I., & Sprung, C. L. (2001) · Intensive Care Medicine · doi:10.1007/pl00003795 · Cited by 153 · see citing works

Letter to the Editor

Gionchetti, P., Rizzello, F., Ferrieri, A., Venturi, A., Brignola, C., Ferretti, M., Peruzzo, S., Miglioli, M., & Campieri, M. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026648812439 · Cited by 150 · see citing works

Somatic Mutation, Monoclonality and Stochastic Models of Stem Cell Organization in the Intestinal Crypt

Loeffler, M., Birke, A., Winton, D. J., & Potten, C. S. (1993) · Journal of Theoretical Biology · doi:10.1006/jtbi.1993.1031 · Cited by 149 · see citing works

Probiotic Yogurt Consumption is Associated With an Increase of CD4 Count Among People Living With HIV/AIDS

Irvine, S. L., Hummelen, R., Hekmat, S., Looman, C. W. N., Habbema, J. D. F., & Reid, G. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181d8fba8 · Cited by 147 · see citing works

Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohnʼs disease

Buchman, A. L., Katz, S., Fang, J. C., Bernstein, C. N., & Abou‐Assi, S. G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21117 · Cited by 144 · see citing works

High-Density Lipoprotein Suppresses the Type I Interferon Response, a Family of Potent Antiviral Immunoregulators, in Macrophages Challenged With Lipopolysaccharide

Suzuki, M., Pritchard, D. K., Becker, L., Hoofnagle, A. N., Tanimura, N., Bammler, T. K., Beyer, R. P., Bumgarner, R. E., Vaisar, T., de Beer, M. C., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.961193 · Cited by 143 · see citing works

IgA deficiency: clinical correlates and responses to pneumococcal vaccine

Edwards, E., Razvi, S., & Cunningham‐Rundles, C. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.12.005 · Cited by 139 · see citing works

Histochemical, Lectin-Histochemical and Morphometrical Characteristics of Intestinal Goblet Cells of Germfree and Conventional Mice.

Kandori, H., Hirayama, K., TAKEDA, M., & Doi, K. (1996) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.45.155 · Cited by 138 · see citing works

Prevalence and Diagnosis of Celiac Disease in IgA-Deficient Children

Meini, A., Pillan, M. N., Ugazio, A. G., Villanacci, V., Monafò, V., & Plebani, A. (1996) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63329-7 · Cited by 135 · see citing works

Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype

Sato, W., Aranami, T., & Yamamura, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7525 · Cited by 134 · see citing works

Development of A New, Simple Rat Model of Early Alcohol–Induced Liver Injury Based on Sensitization of Kupffer Cells

Enomoto, N., Yamashina, S., Kono, H., Schemmer, P., Rivera, C. A., Enomoto, A., Nishiura, T., Nishimura, T., Brenner, D. A., & Thurman, R. G. (1999) · Hepatology · doi:10.1002/hep.510290633 · Cited by 132 · see citing works

Simian Immunodeficiency Virus–Induced Intestinal Cell Apoptosis Is the Underlying Mechanism of the Regenerative Enteropathy of Early Infection

Li, Q., Estes, J. D., Duan, L., Jessurun, J., Pambuccian, S. E., Forster, C. L., Wietgrefe, S. W., Zupancic, M., Schacker, T. W., Reilly, C., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/525046 · Cited by 131 · see citing works

CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART

Massanella, M., Negredo, E., Pérez‐Álvarez, N., Puig, J., Ruiz‐Hernandez, R., Bofill, M., Clotet, B., & Blanco, J. (2010) · AIDS · doi:10.1097/qad.0b013e328337b957 · Cited by 130 · see citing works

Helicobacter pylori Activates Myosin Light-Chain Kinase To Disrupt Claudin-4 and Claudin-5 and Increase Epithelial Permeability

Fedwick, J. P., Lapointe, T. K., Meddings, J. B., Sherman, P. M., & Buret, A. G. (2005) · Infection and Immunity · doi:10.1128/iai.73.12.7844-7852.2005 · Cited by 129 · see citing works

Evidence that sustained growth suppression of intestinal anaerobic bacteria reduces the risk of acute graft-versus-host disease after sibling marrow transplantation

Beelen, D., Haralambie, E., Brandt, H., Linzenmeier, G., Muller, K., Quabeck, K., Sayer, H., Graeven, U., Mahmoud, H., & Schaefer, U. (1992) · Blood · doi:10.1182/blood.v80.10.2668.2668 · Cited by 128 · see citing works

Utilization of the Intestinal Tract as a Delivery System for Urogenital Probiotics

Morelli, L., Zonenenschain, D., Piano, M. D., & Cognein, P. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128938.32835.98 · Cited by 126 · see citing works

In Vitro Binding of Potent Mutagenic Pyrolyzates to Intestinal Bacteria

Morotomi, M., & Mutal, M. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/77.1.195 · Cited by 123 · see citing works

IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues

Gurney, A. L. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.016 · Cited by 120 · see citing works

Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance

Caradonna, L., Amati, L., Magrone, T., Pellegrino, N. M., Jirillo, E., & Caccavo, D. (2000) · Journal of Endotoxin Research · doi:10.1179/096805100101532063 · Cited by 120 · see citing works

Bifidobacterium pseudocatenulatum is associated with atopic eczema: A nested case-control study investigating the fecal microbiota of infants

Gore, C., Munro, K., Lay, C., Bibiloni, R., Morris, J., Woodcock, A. A., Čustović, A., & Tannock, G. W. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.061 · Cited by 116 · see citing works

The association of giardiasis with reduced intestinal secretory immunoglobulin A

Zinneman, H. H., & Kaplan, A. P. (1972) · Digestive Diseases and Sciences · doi:10.1007/bf02231148 · Cited by 115 · see citing works

Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.

Roth, K. A., Hertz, J., & Gordon, J. I. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.5.1791 · Cited by 115 · see citing works

Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 Infections

Nowroozalizadeh, S., Månsson, F., da Silva, Z. J., Repits, J., Dabo, B., Pereira, C. C., Biague, A. J., Albert, J., Nielsen, J. O., Aaby, P., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/651430 · Cited by 115 · see citing works

CpG Motifs of Bacterial DNA Essentially Contribute to the Perpetuation of Chronic Intestinal Inflammation

Obermeier, F., Dunger, N., Strauch, U., Hofmann, C., Bleich, A., Grunwald, N., Hedrich, H. J., Aschenbrenner, E., Schlegelberger, B., Rogler, G., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.061 · Cited by 112 · see citing works

Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat

Pappo, I., Becovier, H., Berry, E. M., & Freund, H. R. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90078-z · Cited by 111 · see citing works

Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation

Lorenz, E., Schwartz, D. A., Martin, P. J., Gooley, T. A., Lin, M.-T., Chien, J. W., Hansen, J. A., & Clark, J. G. (2001) · Transplantation and Cellular Therapy · doi:10.1053/bbmt.2001.v7.pm11529488 · Cited by 109 · see citing works

Tumor necrosis factor: immunologic, antitumor, metabolic, and cardiovascular activities.

Grünfeld, C., & Palladino, M. A. (1990) · PubMed · Cited by 106 · see citing works

The Microbiota and Allergies/Asthma

Huffnagle, G. B. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000549 · Cited by 103 · see citing works

The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease

Cooke, K. R., Olkiewicz, K. M., Erickson, N. T., & Ferrara, J. L. M. (2002) · Journal of Endotoxin Research · doi:10.1177/09680519020080061301 · Cited by 101 · see citing works

CONCENTRATIONS OF LIPOPOLYSACCHARIDE-BINDING PROTEIN, BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN, SOLUBLE CD14 AND PLASMA LIPIDS IN RELATION TO ENDOTOXAEMIA IN PATIENTS WITH ALCOHOLIC LIVER DISEASE

Schäfer, C. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.1.81 · Cited by 99 · see citing works

Role of endotoxin in the hypermetabolic state after acute ethanol exposure

Rivera, C. A., Bradford, B. U., Seabra, V., & Thurman, R. G. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1252 · Cited by 99 · see citing works

Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor α

Ruemmele, F. M., Beaulieu, J., Dionne, S., Levy, E. H., Seidman, E. G., Cerf–Bensussan, N., & Lentze, M. J. (2002) · Gut · doi:10.1136/gut.51.6.842 · Cited by 97 · see citing works

Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases

Oliver, K. M., Taylor, C. T., & Cummins, E. P. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2575 · Cited by 91 · see citing works

Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohnʼs disease and murine colitis

Pasternak, B. A., D’Mello, S., Jurickova, I., Han, X., Willson, T. A., Flick, L. M., Petiniot, L. K., Uozumi, N., Divanovic, S., Trauernicht, A. K., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21132 · Cited by 91 · see citing works

Endogenous endotoxin-core antibody (EndoCAb) as a marker of endotoxin exposure and a prognostic indicator: a review.

Barclay, G. R. (1995) · PubMed · Cited by 90 · see citing works

Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohnʼs disease

Lakatos, P. L., Kiss, L. S., Palatka, K., Altorjay, I., Antal‐Szalmás, P., Pályu, E., Udvardy, M., Molnár, T., Farkas, K., Veres, G., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21402 · Cited by 86 · see citing works

Loss of IL-17–Producing CD8 T Cells during Late Chronic Stage of Pathogenic Simian Immunodeficiency Virus Infection

Nigam, P., Kwa, S., Velu, V., & Amara, R. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002807 · Cited by 81 · see citing works

HIV suppression by HAART preserves cognitive function in advanced, immune-reconstituted AIDS patients

McCutchan, J. A., Wu, J. W., Robertson, K., Koletar, S. L., Ellis, R. J., Cohn, S. E., Taylor, M. J., Woods, S. P., Heaton, R. K., Currier, J. S., et al. (2007) · AIDS · doi:10.1097/qad.0b013e3280ef6acd · Cited by 81 · see citing works

The Early Increase in Intestinal Permeability and Systemic Endotoxin Exposure in Patients with Severe Acute Pancreatitis Is Not Associated with Systemic Bacterial Translocation: Molecular Investigation of Microbial DNA in the Blood

Ammori, B. J., Fitzgerald, P., Hawkey, P. M., & McMahon, M. J. (2003) · Pancreas · doi:10.1097/00006676-200301000-00004 · Cited by 79 · see citing works

Dietary Plasma Protein Supplements Prevent the Release of Mucosal Proinflammatory Mediators in Intestinal Inflammation in Rats

Pérez‐Bosque, A., Miró, L., Polo, J., Russell, L., Campbell, J. M., Weaver, E. M., Crenshaw, J., & Moretó, M. (2009) · Journal of Nutrition · doi:10.3945/jn.109.112466 · Cited by 75 · see citing works

Phagocytosis, killing, lymphocyte-mediated antibacterial activity, serum autoantibodies, and plasma endotoxins in inflammatory bowel disease

Caradonna, L., Amati, L., Lella, P., Jirillo, E., & Caccavo, D. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02085.x · Cited by 72 · see citing works

Immune reconstitution in human immunodeficiency virus type 1-infected children with different virological responses to anti-retroviral therapy

Anselmi, A., Vendrame, D., Rampon, O., Giaquinto, C., Zanchetta, M., & Rossi, A. D. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03526.x · Cited by 72 · see citing works

Mucosal Bacterial Growth in the Upper Gastrointestinal Tract in Alcoholics (Heavy Drinkers)

Hauge, T., Persson, J., & Danielsson, D. G. (2009) · Digestion · doi:10.1159/000201507 · Cited by 69 · see citing works

Natural Human Antibodies to Gram-Negative Bacteria: Immunoglobulins G, A, and M

Cohen, I. R., & Norins, L. C. (1966) · Science · doi:10.1126/science.152.3726.1257 · Cited by 69 · see citing works

Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution

Balagopal, A., Ray, S. C., de Oca, R. M., Sutcliffe, C. G., Vivekanandan, P., Higgins, Y., Mehta, S. H., Moore, R. D., Sulkowski, M., Thomas, D. L., et al. (2009) · AIDS · doi:10.1097/qad.0b013e3283324344 · Cited by 67 · see citing works

Biological and Clinical Significance of Endotoxemia in the Course of Hepatitis C Virus Infection

Caradonna, L., Mastronardi, M., Magrone, T., Cozzolongo, R., Cuppone, R., Manghisi, O. G., Caccavo, D., Pellegrino, N. M., Amoroso, A., Jirillo, E., et al. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612024606983 · Cited by 66 · see citing works

Altered small-intestinal permeability associated with diarrhoea in human-immunodeficiency-virus-infected Caucasian and African subjects

Kapembwa, M. S., Fleming, S. C., Sewankambo, N. K., Serwadda, D., Lucas, S. B., Moody, A. H., & Griffin, G. E. (1991) · Clinical Science · doi:10.1042/cs0810327 · Cited by 65 · see citing works

Relationship of antibodies to endotoxin core to mortality in medical patients with sepsis syndrome

Strutz, F. M., Heller, G., Krasemann, K., Krone, B., & Muller, G. A. (1999) · Intensive Care Medicine · doi:10.1007/s001340050877 · Cited by 60 · see citing works

Systemic toll-like receptor ligands modify B-cell responses in human inflammatory bowel disease

McDonnell, M. E., Liang, Y., Noronha, A. M., Coukos, J. A., Kasper, D. L., Farraye, F. A., & Ganley-Leal, L. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21424 · Cited by 60 · see citing works

Dietary Plasma Proteins Modulate the Immune Response of Diffuse Gut-Associated Lymphoid Tissue in Rats Challenged with Staphylococcus aureus Enterotoxin B

Pérez‐Bosque, A., Miró, L., Polo, J., Russell, L., Campbell, J. M., Weaver, E. M., Crenshaw, J., & Moretó, M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.533 · Cited by 59 · see citing works

Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50copies/ml HIV-1 RNA

Baroncelli, S., Galluzzo, C. M., Pirillo, M. F., Mancini, M. G., Weimer, L. E., Andreotti, M., Amici, R., Vella, S., Giuliano, M., & Palmisano, L. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.09.011 · Cited by 58 · see citing works

Scavenger receptor pathway for lipopolysaccharide binding to Kupffer and endothelial liver cells in vitro

Shnyra, A., & Lindberg, A. A. (1995) · Infection and Immunity · doi:10.1128/iai.63.3.865-873.1995 · Cited by 58 · see citing works

A Study of Intestinal Permeability in Relation to the Inflammatory Response and Plasma Endocab IgM Levels in Patients with Acute Pancreatitis

Penalva, J. C., Martínez, J. F., Laveda, R., Esteban, A., Muñoz, C., Sáez, J., Such, J. M., Navarro, S., Feu, F., Sánchez–Payá, J., et al. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000129060.46654.e0 · Cited by 55 · see citing works

Cytokine association with bacterial DNA in serum of patients with inflammatory bowel disease

Gutiérrez, A., Francés, R., Amorós, A., Zapater, P., Garmendia, M., NDongo, M., Caño, R., Jover, R., Such, J. M., & Pérez‐Mateo, M. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20806 · Cited by 55 · see citing works

Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus

Corl, B. A., Harrell, R. J., Moon, H. K., Phillips, O., Weaver, E. M., Campbell, J. M., Arthington, J. D., & Odle, J. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.12.011 · Cited by 51 · see citing works

Serum proteins and lymphoid tissues in germ-free mice fed a chemically defined, water soluble, low molecular weight diet.

Wöstmann, B. S. J., Pleasants, J. R., Bealmear, P. M., & Kincade, P. W. (1970) · PubMed Central · Cited by 49 · see citing works

Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patients

Papasavvas, E., Pistilli, M., Reynolds, G., Bucki, R., Azzoni, L., Chehimi, J., Janmey, P. A., DiNubile, M. J., Ondercin, J., Kostman, J. R., et al. (2009) · AIDS · doi:10.1097/qad.0b013e32831e9c76 · Cited by 49 · see citing works

Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers

Singh, R., Bullard, J., Kalra, M., Assefa, S., Kaul, A., Vonfeldt, K., Strom, S. C., Conrad, R., Sharp, H. L., & Kaul, R. (2010) · Clinical Immunology · doi:10.1016/j.clim.2010.09.006 · Cited by 46 · see citing works

The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease

Cooke, K. R., Olkiewicz, K. M., Erickson, N. T., & Ferrara, J. L. M. (2002) · Journal of Endotoxin Research · doi:10.1179/096805102125001046 · Cited by 46 · see citing works

Role of the microbiota in immunity and inflammation.

Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · see citing works

Interactions between the microbiota, immune and nervous systems in health and disease

Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327 · see citing works

The Human Microbiota in Health and Disease

Wang, B., Yao, M., Lv, L., Ling, Z., & Li, L. (2017) · Engineering · doi:10.1016/j.eng.2017.01.008 · Cited by 861 · see citing works

Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature · doi:10.1038/nature15367 · Cited by 839 · see citing works

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

Sonnenberg, G. F., Monticelli, L. A., Alenghat, T., Fung, T. C., Hutnick, N. A., Kunisawa, J., Shibata, N., Grunberg, S., Sinha, R., Zahm, A. M., et al. (2012) · Science · doi:10.1126/science.1222551 · Cited by 738 · see citing works

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Scheithauer, T. P. M., Rampanelli, E., Nieuwdorp, M., Vallance, B. A., Verchere, C. B., van Raalte, D. H., & Herrema, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571731 · Cited by 694 · see citing works

The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease

Guerrant, R. L., DeBoer, M. D., Moore, S. R., Scharf, R. J., & Lima, A. A. M. (2013) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2012.239 · Cited by 604 · see citing works

Leaky Gut As a Danger Signal for Autoimmune Diseases

Mu, Q., Kirby, J. L., Reilly, C. M., & Luo, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00598 · Cited by 618 · see citing works

Immunopathology of inflammatory bowel disease

Wallace, K. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i1.6 · Cited by 581 · see citing works

CD 4 + T‐cell depletion in HIV infection: mechanisms of immunological failure

Okoye, A. A., & Picker, L. J. (2013) · Immunological Reviews · doi:10.1111/imr.12066 · Cited by 571 · see citing works

Development of intestinal microbiota in infants and its impact on health

Matamoros, S., Guen, C. G., Vacon, F. L., Potel, G., & de la Cochetière, M.-F. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2012.12.001 · Cited by 533 · see citing works

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

Dinh, D. M., Volpe, G. E., Duffalo, C., Bhalchandra, S., Tai, A., Kane, A. V., WANKE, C. A., & Ward, H. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu409 · Cited by 531 · see citing works

Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

Marchetti, G. C., Tincati, C., & Silvestri, G. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00050-12 · Cited by 502 · see citing works

The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease

Anders, H., Andersen, K., & Stecher, B. (2013) · Kidney International · doi:10.1038/ki.2012.440 · Cited by 495 · see citing works

The endotoxin hypothesis of neurodegeneration

Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457 · see citing works

Gut Microbiota Linked to Sexual Preference and HIV Infection

Noguera-Julián, M., Rocafort, M., Guillén, Y., Rivera, J., Casadellà, M., Nowak, P., Hildebrand, F., Zeller, G., Parera, M., Bellido, R., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.032 · Cited by 448 · see citing works

Immune activation and HIV persistence: implications for curative approaches to HIV infection

Klatt, N. R., Chomont, N., Douek, D. C., & Deeks, S. G. (2013) · Immunological Reviews · doi:10.1111/imr.12065 · Cited by 439 · see citing works

Microbial translocation, immune activation, and HIV disease

Klatt, N. R., Funderburg, N., & Brenchley, J. M. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.09.001 · Cited by 390 · see citing works

Type 2 immunity in allergic diseases

Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Ardıçlı, S., Li, M., D’Avino, P., Beha, C., Babayev, H., Zhao, B., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01261-2 · Cited by 413 · see citing works

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

Leeansyah, E., Ganesh, A., Quigley, M. F., Sönnerborg, A. B., Andersson, J., Hunt, P. W., Somsouk, M., Deeks, S. G., Martin, J. N., Moll, M., et al. (2012) · Blood · doi:10.1182/blood-2012-07-445429 · Cited by 372 · see citing works

Residual Immune Dysregulation Syndrome in Treated HIV infection

Lederman, M. M., Funderburg, N., Sékaly, R., Klatt, N. R., & Hunt, P. W. (2013) · Advances in immunology · doi:10.1016/b978-0-12-407707-2.00002-3 · Cited by 348 · see citing works

Hookworm infection

Loukas, A. C., Hotez, P. J., Diemert, D. J., Yazdanbakhsh, M., McCarthy, J. S., Corrêa‐Oliveira, R., Croese, J., & Bethony, J. M. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.88 · Cited by 336 · see citing works

Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing

Kurashima, Y., & Kiyono, H. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052424 · Cited by 331 · see citing works

Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction

Zhou, X., Li, J., Guo, J., Geng, B., Ji, W., Zhao, Q., Li, J., Liu, X., Liu, J., Guo, Z.-Z., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0441-4 · Cited by 305 · see citing works

Cancer-promoting effects of microbial dysbiosis

Sheflin, A. M., Whitney, A. K., & Weir, T. L. (2014) · Current Oncology Reports · doi:10.1007/s11912-014-0406-0 · Cited by 301 · see citing works

Environmental Enteric Dysfunction: Pathogenesis, Diagnosis, and Clinical Consequences

Keusch, G. T., Denno, D. M., Black, R. E., Duggan, C., Guerrant, R. L., Lavery, J. V., Nataro, J. P., Rosenberg, I. H., Ryan, E. T., Tarr, P. I., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu485 · Cited by 294 · see citing works

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

Alkanani, A. K., Hara, N., Gottlieb, P. A., Ir, D., Robertson, C. E., Wagner, B. D., Frank, D. N., & Zipris, D. (2015) · Diabetes · doi:10.2337/db14-1847 · Cited by 287 · see citing works

Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications

Le Bastard, Q., Al‐Ghalith, G. A., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Knights, D., & Montassier, E. (2018) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.14451 · Cited by 263 · see citing works

Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome

Handley, S., Thackray, L. B., Zhao, G.-Y., Presti, R., Miller, A. D., Droit, L., Abbink, P., Maxfield, L. F., Kambal, A., Duan, E.-N., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.024 · Cited by 287 · see citing works

Innate Lymphoid Cell Interactions with Microbiota: Implications for Intestinal Health and Disease

Sonnenberg, G. F., & Artis, D. (2012) · Immunity · doi:10.1016/j.immuni.2012.10.003 · Cited by 272 · see citing works

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

Banerjee, S., Sindberg, G., Wang, F., Meng, J., Sharma, U., Zhang, L., Dauer, P., Chen, C., Dalluge, J., Johnson, T., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.9 · Cited by 266 · see citing works

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

Bowers, N. L., Helton, E. S., Huijbregts, R. P. H., Goepfert, P., Heath, S. L., & Hel, Z. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003993 · Cited by 256 · see citing works

Nonhuman primate models of human viral infections

Estes, J. D., Wong, S. W., & Brenchley, J. M. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0005-7 · Cited by 252 · see citing works

HIV infection is associated with compositional and functional shifts in the rectal mucosal microbiota

McHardy, I. H., Li, X., Tong, M., Ruegger, P., Jacobs, J., Borneman, J., Anton, P., & Braun, J. (2013) · Microbiome · doi:10.1186/2049-2618-1-26 · Cited by 234 · see citing works

Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease

Uhde, M., Ajamian, M., Caio, G., GIORGIO, R. D., Indart, A. C., Green, P. H., Verna, E. C., Volta, U., & Alaedini, A. (2016) · Gut · doi:10.1136/gutjnl-2016-311964 · Cited by 232 · see citing works

Inside the Mucosal Immune System

McGhee, J. R., & Fujihashi, K. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001397 · Cited by 225 · see citing works

Neutrophils: from IBD to the gut microbiota

Danne, C., Skerniškytė, J., Marteyn, B. S., & Sokol, H. (2023) · Nature reviews: Gastroenterology & hepatology · doi:10.1038/s41575-023-00871-3 · Cited by 227 · see citing works

Environmental enteric dysfunction pathways and child stunting: A systematic review

Harper, K. M., Mutasa, M., Prendergast, A. J., Humphrey, J. H., & Manges, A. R. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006205 · Cited by 225 · see citing works

Preventing environmental enteric dysfunction through improved water, sanitation and hygiene: an opportunity for stunting reduction in developing countries

Mbuya, M. N. N., & Humphrey, J. H. (2015) · Maternal and Child Nutrition · doi:10.1111/mcn.12220 · Cited by 217 · see citing works

Gut microbiota and colorectal cancer

Gao, R., Gao, Z., Huang, L., & Qin, H. (2017) · European Journal of Clinical Microbiology &amp; Infectious Diseases · doi:10.1007/s10096-016-2881-8 · Cited by 205 · see citing works

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

Song, W., Tiruthani, K., Wang, Y., Shen, L., Hu, M., Dorosheva, O., Qiu, K., Kinghorn, K., Liu, R., & Huang, L. (2018) · Advanced Materials · doi:10.1002/adma.201805007 · Cited by 194 · see citing works

HIV as a Cause of Immune Activation and Immunosenescence

Sokoya, T., Steel, H. C., Nieuwoudt, M., & Rossouw, T. M. (2017) · Mediators of Inflammation · doi:10.1155/2017/6825493 · Cited by 194 · see citing works

Protective Microbiota: From Localized to Long-Reaching Co-Immunity

Chiu, L., Bazin, T., Truchetet, M., Schaeverbeke, T., Delhaès, L., & Pradeu, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01678 · Cited by 192 · see citing works

Gut microbiota: a key player in health and disease. A review focused on obesity

Villanueva-Millán, M. J., Pérez‐Matute, P., & Oteo, J. A. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0390-3 · Cited by 185 · see citing works

Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo

Bittel, M., Reichert, P., Sarfati, I., Dressel, A., Leikam, S., Uderhardt, S., Stolzer, I., Phu, T. A., Ng, M., Vu, N. K., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12159 · Cited by 180 · see citing works

Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection

Wang, C., Li, Q., & Ren, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01873 · Cited by 167 · see citing works

The price of immunity

Goldszmid, R. S., & Trinchieri, G. (2012) · Nature Immunology · doi:10.1038/ni.2422 · Cited by 164 · see citing works

The gut microbiome and HIV-1 pathogenesis

Dillon, S. M., Frank, D. N., & Wilson, C. C. (2016) · AIDS · doi:10.1097/qad.0000000000001289 · Cited by 162 · see citing works

IVIg Immune Reconstitution Treatment Alleviates the State of Persistent Immune Activation and Suppressed CD4 T Cell Counts in CVID

Paquin‐Proulx, D., Santos, B. A. N., Carvalho, K. I., Toledo-Barros, M. A. M., de Oliveira, A. K. B., Kokron, C. M., Kalil, J. E., Moll, M., Kallas, E. G., & Sandberg, J. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075199 · Cited by 158 · see citing works

Immunosenescence and inflammaging: Mechanisms and role in diseases

Ajoolabady, A., Praticò, D., Tang, D., Zhou, S., Franceschi, C., & Ren, J. T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102540 · Cited by 160 · see citing works

Immunopathogenesis of lymphatic filarial disease

Babu, S., & Nutman, T. B. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0346-4 · Cited by 150 · see citing works

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism

Fung, T. C., Bessman, N. J., Hepworth, M. R., Kumar, N., Shibata, N., Kobuley, D. E., Wang, K., Ziegler, C. G. K., Goc, J., Shima, T., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.019 · Cited by 149 · see citing works

Nonhuman primate models in AIDS research

Evans, D. T., & Silvestri, G. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328361cee8 · Cited by 148 · see citing works

Cross talk between neutrophils and the microbiota

Zhang, D., & Frenette, P. S. (2019) · Blood · doi:10.1182/blood-2018-11-844555 · Cited by 148 · see citing works

HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy

Gosselin, A., Salinas, T. R. W., Planas, D., Wacleche, V. S., Zhang, Y., Fromentin, R., Chomont, N., Cohen, É. A., Shacklett, B. L., Mehraj, V., et al. (2016) · AIDS · doi:10.1097/qad.0000000000001309 · Cited by 136 · see citing works

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome

McAleer, J. P., Nguyen, N. L. H., Chen, K., Kumar, P., Ricks, D. M., Binnie, M., Armentrout, R., Pociask, D. A., Hein, A., Yu, A. C., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502566 · Cited by 126 · see citing works

Immunology of pediatric HIV infection

Tobin, N. H., & Aldrovandi, G. M. (2013) · Immunological Reviews · doi:10.1111/imr.12074 · Cited by 124 · see citing works

Pathobiology of HIV / SIV ‐associated changes in secondary lymphoid tissues

Estes, J. D. (2013) · Immunological Reviews · doi:10.1111/imr.12070 · Cited by 118 · see citing works

Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence

Zam, W. (2018) · Journal of Nutrition and Metabolism · doi:10.1155/2018/1367984 · Cited by 117 · see citing works

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells

Antonopoulos, C. H., Sanadi, C. E. E., Kaiser, W. J., Mocarski, E. S., & Dubyak, G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300645 · Cited by 114 · see citing works

Blood Microbiome Profile in CKD

Shah, N. B., Allegretti, A. S., Nigwekar, S. U., Kalim, S., Zhao, S. J., Lelouvier, B., Servant, F., Serena, G., Thadhani, R., Raj, D. S., et al. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12161018 · Cited by 115 · see citing works

Spotlight on the Gut Microbiome in Menopause: Current Insights

Peters, B. A., Santoro, N. F., Kaplan, R. C., & Qi, Q. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s340491 · Cited by 125 · see citing works

Toll-Like Receptor 2 Activation by β2→1-Fructans Protects Barrier Function of T84 Human Intestinal Epithelial Cells in a Chain Length–Dependent Manner

Vogt, L. M., Meyer, D., Pullens, G., Faas, M. M., Venema, K., Ramasamy, U. S., Schols, H. A., & de Vos, P. (2014) · Journal of Nutrition · doi:10.3945/jn.114.191643 · Cited by 114 · see citing works

Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease

Kaur, H., Nagamoto‐Combs, K., Golovko, S. A., Golovko, M. Y., Klug, M. G., & Combs, C. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.009 · Cited by 112 · see citing works

The Th17/Treg Ratio, IL-1RA and sCD14 Levels in Primary HIV Infection Predict the T-cell Activation Set Point in the Absence of Systemic Microbial Translocation

Chevalier, M. F., Petitjean, G., Dunyach‐Remy, C., Didier, C., Girard, P., Manea, M. E., Campa, P., Meyer, L., Rouzioux, C., Lavigne, J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003453 · Cited by 112 · see citing works

Severe COVID-19: A Review of Recent Progress With a Look Toward the Future

Xie, P., Ma, W., Tang, H., & Liu, D. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00189 · Cited by 110 · see citing works

Altered gut microbiome composition in HIV infection

Bandera, A., Benedetto, I. D., Bozzi, G., & Gori, A. (2017) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000429 · Cited by 111 · see citing works

The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis

Wacleche, V. S., LANDAY, A. L., Routy, J., & Ancuța, P. (2017) · Viruses · doi:10.3390/v9100303 · Cited by 105 · see citing works

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

Pallikkuth, S., Micci, L., Ende, Z. S., Iriele, R. I., Cervasi, B., Lawson, B., McGary, C. S., Rogers, K. A., Else, J. G., Silvestri, G., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003471 · Cited by 103 · see citing works

HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation

Gootenberg, D. B., Paer, J. M., Luévano, J. M., & Kwon, D. S. (2016) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000341 · Cited by 101 · see citing works

The potential of the microbiota to influence vaccine responses

Lynn, D. J., & Pulendran, B. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5mr0617-216r · Cited by 97 · see citing works

Sex differences in gut fermentation and immune parameters in rats fed an oligofructose-supplemented diet

Shastri, P., McCarville, J. L., Kalmokoff, M. L., Brooks, S. P. J., & Green-Johnson, J. M. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0031-0 · Cited by 98 · see citing works

Multiple Organ Dysfunction Syndrome in Humans and Animals

Osterbur, K., Mann, F. A., Kuroki, K., & DeClue, A. E. (2014) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12364 · Cited by 97 · see citing works

Identification and Characterization of Blood and Neutrophil-Associated Microbiomes in Patients with Severe Acute Pancreatitis Using Next-Generation Sequencing

Li, Q., Wang, C., Tang, C. X., Zhao, X., He, Q., & Li, J. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00005 · Cited by 96 · see citing works

Gut barrier dysfunction and microbial translocation in cancer cachexia

Klein, G. L., Petschow, B. W., Shaw, A. L., & Weaver, E. M. (2013) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000017 · Cited by 95 · see citing works

Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia

Amadi, B., Besa, E. C., Zyambo, K., Kaonga, P., Louis-Auguste, J., Chandwe, K., Tarr, P. I., Denno, D. M., Nataro, J. P., Faubion, W. A., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.07.017 · Cited by 93 · see citing works

Lupus mesenteric vasculitis: Clinical features and associated factors for the recurrence and prognosis of disease

Yuan, S., Ye, Y., Chen, D., Qiu, Q., Zhan, Z., Lian, F., Li, H., Liang, L., Xu, H., & Yang, X. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.11.005 · Cited by 93 · see citing works

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

Kristoff, J., Haret-Richter, G. S., Ma, D., Ribeiro, R. M., Xu, C., Cornell, E. S., Stock, J. L., He, T., Mobley, A. D., Ross, S., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75090 · Cited by 91 · see citing works

Endomicroscopic and Transcriptomic Analysis of Impaired Barrier Function and Malabsorption in Environmental Enteropathy

Kelly, P. M., Besa, E. C., Zyambo, K., Louis-Auguste, J., Lees, J. D., Banda, T., Soko, R., Banda, R., Amadi, B., & Watson, A. J. M. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004600 · Cited by 91 · see citing works

Insights into the Pathogenesis of Disease in Human Lymphatic Filariasis

Nutman, T. B. (2013) · Lymphatic Research and Biology · doi:10.1089/lrb.2013.0021 · Cited by 90 · see citing works

The microbiome in autoimmune rheumatic disease

Konig, M. F. (2020) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.101473 · Cited by 89 · see citing works

HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms

Planas, D., Zhang, Y., Monteiro, P., Goulet, J.-P., Gosselin, A., Grandvaux, N., Hope, T. J., Fassati, A., Routy, J., & Ancuța, P. (2017) · JCI Insight · doi:10.1172/jci.insight.93230 · Cited by 88 · see citing works

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Shah, Z., & Alsegiani, A. S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335837 · Cited by 85 · see citing works

A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First‐Degree Relatives of Systemic Lupus Erythematosus Patients

Ogunrinde, E., Zhou, Z., Luo, Z., Alekseyenko, A. V., Li, Q., Macêdo, D. S., Kamen, D. L., Oates, J. C., Gilkeson, G. S., & Jiang, W. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40935 · Cited by 82 · see citing works

The intestinal immune system and gut barrier function in obesity and ageing

Shemtov, S. J., Emani, R., Bielska, O., Covarrubias, A. J., Verdin, E. M., Andersen, J. K., & Winer, D. A. (2022) · FEBS Journal · doi:10.1111/febs.16558 · Cited by 83 · see citing works

IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation

Conrey, P. E., Denu, L., O’Boyle, K. C., Rozich, I., Green, J., Maslanka, J. R., Lubin, J., Duranova, T., Haltzman, B. L., Gianchetti, L., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.ade2335 · Cited by 81 · see citing works

Effector and memory T cell responses to commensal bacteria

Belkaid, Y., Bouladoux, N. J., & Hand, T. W. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.003 · Cited by 80 · see citing works

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

Hauwermeiren, F. V., Armaka, M., Karagianni, N., Kranidioti, K., Vandenbroucke, R. E., Loges, S., Roy, M. V., Staelens, J., Puimège, L., Palagani, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65624 · Cited by 78 · see citing works

Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells

Zhou, Z., Bian, C., Luo, Z., Guille, C., Ogunrinde, E., Wu, J., Zhao, M., Fitting, S., Kamen, D. L., Oates, J. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44448-0 · Cited by 78 · see citing works

Preventing Bacterial Translocation in Patients with Leaky Gut Syndrome: Nutrition and Pharmacological Treatment Options

Twardowska, A., Makaro, A., Binienda, A., Fichna, J., & Sałaga, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063204 · Cited by 78 · see citing works

The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection

Mazzuti, L., Turriziani, O., & Mezzaroma, I. (2023) · Biomedicines · doi:10.3390/biomedicines11010159 · Cited by 77 · see citing works

Anti-inflammatory activities of green tea catechins along the gut–liver axis in nonalcoholic fatty liver disease: lessons learned from preclinical and human studies

Hodges, J. K., Sasaki, G. Y., & Bruno, R. S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108478 · Cited by 76 · see citing works

Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis

Brandl, C., Bucci, L., Schett, G. A., & Zaiss, M. M. (2021) · European Journal of Immunology · doi:10.1002/eji.202048876 · Cited by 75 · see citing works

Recent advances in the epithelial barrier theory

Pat, Y., Yazıcı, D., D’Avino, P., Li, M., Ardıçlı, S., Ardıçlı, Ö., Mitamura, Y., Akdiş, M., Dhir, R., Nadeau, K. C., et al. (2024) · International Immunology · doi:10.1093/intimm/dxae002 · Cited by 75 · see citing works

Circulating Biomarkers of Pulmonary and Extrapulmonary Tuberculosis in Children

Kumar, N. P., Rajamanickam, A., Andrade, B. B., Suresh, N., Ganesh, R., Shankar, J., Kumaraswami, V., Nutman, T. B., & Babu, S. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00038-13 · Cited by 76 · see citing works

The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

Sampsell, K., Hao, D., & Reimer, R. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239239 · Cited by 70 · see citing works

Mucosal immunity in human and simian immunodeficiency lentivirus infections

Brenchley, J. M. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.15 · Cited by 70 · see citing works

Anatomical localization of commensal bacteria in immune cell homeostasis and disease

Fung, T. C., Artis, D., & Sonnenberg, G. F. (2014) · Immunological Reviews · doi:10.1111/imr.12186 · Cited by 68 · see citing works

Intestinal permeation enhancers to improve oral bioavailability of macromolecules: reasons for low efficacy in humans

Maher, S., Geoghegan, C., & Brayden, D. J. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1825375 · Cited by 71 · see citing works

Editorial Microbial Translocation and Infectious Diseases: What Is the Link?

Douek, D., Paiardini, M., Ceccarelli, G., & Vullo, V. (2012)

Microbial Translocation: from Myth to Mechanism

Marshall, J. C. (2002) · Springer eBooks · doi:10.1007/978-88-470-2213-3_10

Systemic Immunoregulatory Consequences of Gut Commensal Translocation

McPherson, A. C., Pandey, S., Bender, M. J., & Meisel, M. (2021) · Trends in Immunology · doi:10.1016/j.it.2020.12.005 · Cited by 50 · see citing works

Deciphering mechanisms and implications of bacterial translocation in human health and disease

Jin, S., Wetzel, D., & Schirmer, M. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102147 · Cited by 39 · see citing works

Bacterial Translocation to the Mesentery

Ha, C. W. Y., & Devkota, S. (2023) · Progress in inflammation research · doi:10.1007/978-3-031-17774-3_6 · Cited by 2 · see citing works