Cited by 212Listeria monocytogenes in Food SafetyNeonatal and Maternal InfectionsReproductive System and Pregnancy

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Placental Syncytiotrophoblast Constitutes a Major Barrier to Vertical Transmission of Listeria monocytogenes

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Robbins, Jennifer R., Skrzypczynska, Kasia M., Zeldovich, Varvara B., Kapidzic, Mirhan, Bakardjiev, Anna I.·2010·PLoS Pathogens

DOI 10.1371/journal.ppat.1000732PMC PMC2809766

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Abstract

Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L. monocytogenes can infect non-phagocytic cells by two means: direct invasion and cell-to-cell spread. The relative contribution of each method to placental infection is controversial, as is the anatomical site of invasion. Here, we report for the first time the use of first trimester placental organ cultures to quantitatively analyze L. monocytogenes infection of the human placenta. Contrary to previous reports, we found that the syncytiotrophoblast, which constitutes most of the placental surface and is bathed in maternal blood, was highly resistant to L. monocytogenes infection by either internalin-mediated invasion or cell-to-cell spread. Instead, extravillous cytotrophoblasts-which anchor the placenta in the decidua (uterine lining) and abundantly express E-cadherin-served as the primary portal of entry for L. monocytogenes from both extracellular and intracellular compartments. Subsequent bacterial dissemination to the villous stroma, where fetal capillaries are found, was hampered by further cellular and histological barriers. Our study suggests the placenta has evolved multiple mechanisms to resist pathogen infection, especially from maternal blood. These findings provide a novel explanation why almost all placental pathogens have intracellular life cycles: they may need maternal cells to reach the decidua and infect the placenta.

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Authors: Robbins, J. R., Skrzypczynska, K. M., Zeldovich, V. B., Kapidzic, M., & Bakardjiev, A. I.
Affiliations: University of California, San Francisco (US)
Corresponding author: Bakardjiev, Anna I.
ORCID: Robbins, Jennifer R.
Kapidzic, Mirhan
Bakardjiev, Anna I.
Venue: PLoS Pathogens
Publisher: Public Library of Science (PLoS)
Published: 2010-01-22
Volume: 6
Issue: 1
Pages: e1000732
ISSN: 1553-7366 (ISSN-L)
1553-7374
DOI: 10.1371/journal.ppat.1000732
PMC: PMC2809766
OpenAlex: W2047338466
Cited by: 212
References: 78
Citations by year: 2026: 14 · 2025: 17 · 2024: 7 · 2023: 15 · 2022: 12 · 2021: 23 · 2020: 17 · 2019: 11 · 2018: 7 · 2017: 15 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 18 · 2012: 12
FWCI: 11.86
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Pathogens (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Exhibit - A Showcase of Scholarship, Creativity and Preservation Provided by Xavier University Library (Xavier University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Science Foundation
National Institutes of Health
National Institute of Allergy and Infectious Diseases (K08AI064951, T32AI060537)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Listeria monocytogenes in Food Safety
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: Listeria monocytogenes, syncytiotrophoblast, placenta, vertical transmission, maternal-fetal infection, extravillous cytotrophoblast, E-cadherin, cell-to-cell transmission, decidua, placental barrier
MeSH terms: Female, Fluorescent Antibody Technique, Humans, Image Processing, Computer-Assisted, Listeriosis, Listeria monocytogenes, Organ Culture Techniques, Placenta Diseases, Pregnancy, Pregnancy Complications, Infectious, Trophoblasts, Infectious Disease Transmission, Vertical, Microscopy, Confocal

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Placental Syncytiotrophoblast Constitutes a Major Barrier to Vertical Transmission of Listeria monocytogenes

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