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Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

Borjabad, Alejandra, Morgello, Susan, Chao, Wei, Kim, Seon-Young, Brooks, Andrew I., Murray, Jacinta, Potash, Mary Jane, Volsky, David J.·2011·PLoS Pathogens
DOI 10.1371/journal.ppat.1002213PMC PMC3164642
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  • Intersection of the microglia signature gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets.

    “We then intersected this gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders derived from microarray or RNA-seq analysis of intact tissue (39–53). Two-sided Fisher’s exact tests revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets (Table S3).”

    From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [48]

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Authors
Borjabad, A., Morgello, S., Chao, W., Kim, S.-Y., Brooks, A. I., Murray, J., Potash, M. J., & Volsky, D. J.
Venue
PLoS Pathogens
Publisher
Public Library of Science (PLoS)
Published
2011-09-01
Volume
7
Issue
9
Pages
e1002213
ISSN
1553-7374
DOI
10.1371/journal.ppat.1002213
PMC
PMC3164642
Cited by
105
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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