Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks

Maere, S., Heymans, K., & Kuiper, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bti551 · Cited by 4,251 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

Merico, D., Isserlin, R., Stueker, O., Emili, A., & Bader, G. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013984 · Cited by 2,235 · see citing works

Pathways to neuronal injury and apoptosis in HIV-associated dementia

Kaul, M., Garden, G. A., & Lipton, S. A. (2001) · Nature · doi:10.1038/35073667 · Cited by 1,211 · see citing works

Linking lipids to Alzheimer's disease: cholesterol and beyond

Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works

HIV dementia: an evolving disease

McArthur, J. C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.042 · Cited by 469 · see citing works

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

Jacotot, E. D., Ravagnan, L., Loeffler, M. W., Ferri, K. F., Vieira, H. L. A., Zamzami, N., Costantini, P., Druillennec, S., Hoebeke, J., Briand, J. P., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.33 · Cited by 450 · see citing works

HIV-Infected Adults With a CD4 Cell Count Greater Than 500 Cells/mm3 on Long-Term Combination Antiretroviral Therapy Reach Same Mortality Rates as the General Population

Lewden, C., Chêne, G., Morlat, P., Raffi, F., Dupon, M., Dellamonica, P., Pellegrin, J., Katlama, C., Dabis, F., & Leport, C. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318134257a · Cited by 401 · see citing works

Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

Liu, Y., Jones, M., Hingtgen, C. M., Bu, G., Laribee, R. N., Tanzi, R. E., Moir, R. D., Nath, A., & He, J. J. (2000) · Nature Medicine · doi:10.1038/82199 · Cited by 380 · see citing works

Presenting and exploring biological pathways with PathVisio

van Iersel, M., Kelder, T., Pico, A. R., Hanspers, K., Coort, S. L., Conklin, B. R., & Evelo, C. T. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-399 · Cited by 360 · see citing works

HIV-1 transcription and latency: an update

Lint, C. M. V., Bouchat, S., & Marcello, A. (2013) · Retrovirology · doi:10.1186/1742-4690-10-67 · Cited by 336 · see citing works

AltAnalyze and DomainGraph: analyzing and visualizing exon expression data

Emig, D., Salomonis, N., Baumbach, J., Lengauer, T., Conklin, B. R., & Albrecht, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq405 · Cited by 324 · see citing works

Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients

Green, D. A., Masliah, E., Vinters, H. V., Beizai, P., Moore, D. J., & Achim, C. L. (2005) · AIDS · doi:10.1097/01.aids.0000161770.06158.5c · Cited by 299 · see citing works

Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.

Kopp, J. B., Klotman, M. E., Adler, S. H., Bruggeman, L. A., Dickie, P., Marinos, N. J., Eckhaus, M., Bryant, J., Notkins, A. L., & Klotman, P. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1577 · Cited by 298 · see citing works

Dementia and Neurocognitive Disorders Due to HIV-1 Infection

Ances, B. M., & Ellis, R. J. (2007) · Seminars in Neurology · doi:10.1055/s-2006-956759 · Cited by 291 · see citing works

HIV-associated nephropathy in transgenic mice expressing HIV-1 genes

Dickie, P., Felser, J. M., Eckhaus, M., Bryant, J., Silver, J. E., Marinos, N. J., & Notkins, A. L. (1991) · Virology · doi:10.1016/0042-6822(91)90759-5 · Cited by 281 · see citing works

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

Haughey, N. J., Bandaru, V. V. R., Bae, M. H., & Mattson, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.003 · Cited by 271 · see citing works

Perturbation of sphingolipid metabolism and ceramide production in HIV‐dementia

Haughey, N. J., Cutler, R. G., Tamara, A., McArthur, J. C., Vargas, D. L., Pardo, C. A., Turchan-Cholewo, J. T., Nath, A., & Mattson, M. P. (2004) · Annals of Neurology · doi:10.1002/ana.10828 · Cited by 267 · see citing works

HIV tat and neurotoxicity

King, J. E., Eugenin, E. A., Buckner, C. M., & Berman, J. W. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.11.014 · Cited by 230 · see citing works

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Bryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913828107 · Cited by 209 · see citing works

Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals

Rotger, M., Dang, K. K., Fellay, J., Heinzen, E. L., Feng, S., Descombes, P., Shianna, K. V., Ge, D., Günthard, H. F., Goldstein, D. B., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000781 · Cited by 169 · see citing works

HIV TAT Forms Pores in Membranes by Inducing Saddle‐Splay Curvature: Potential Role of Bidentate Hydrogen Bonding

Mishra, A., Gordon, V. D., Yang, L., Coridan, R. H., & Wong, G. C. L. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200704444 · Cited by 167 · see citing works

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

Fitting, S., Ignatowska-Jankowska, B. M., Bull, C., Skoff, R. P., Lichtman, A. H., Wise, L. E., Fox, M. A., Su, J., Medina, A. E., Krahe, T. E., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.026 · Cited by 162 · see citing works

Correlates of Lending Needles/Syringes Among HIV-Seropositive Injection Drug Users

Metsch, L. R., Pereyra, M. R., Purcell, D. W., Latkin, C. A., Malow, R. M., Gomez, C. A., & Latka, M. H. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181576818 · Cited by 159 · see citing works

Statins: Multiple neuroprotective mechanisms in neurodegenerative diseases

Wang, Q., Yan, J., Chen, X., Li, J., Yang, Y., Weng, J., Deng, C., & Yenari, M. A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.04.006 · Cited by 157 · see citing works

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.

Bandaru, V. R., Troncoso, J., Wheeler, D., Pletnikova, O., Wang, J., Conant, K., & Haughey, N. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.024 · Cited by 157 · see citing works

Altered cholesterol and fatty acid metabolism in Huntington disease

Block, R. C., Dorsey, E. R., Beck, C. A., Brenna, J. T., & Shoulson, I. (2010) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2009.11.003 · Cited by 152 · see citing works

Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse

Carey, A. N., Sypek, E. I., Singh, H. D., Kaufman, M. J., & McLaughlin, J. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.019 · Cited by 130 · see citing works

Associative and predictive biomarkers of dementia in HIV-1–infected patients

Bandaru, V. V. R., McArthur, J. C., Sacktor, N. C., Cutler, R. G., Knapp, E. E., Mattson, M. P., & Haughey, N. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260610.79853.47 · Cited by 115 · see citing works

Synaptogenesis of hippocampal neurons in primary cell culture

Grabrucker, A. M., Vaida, B., Bockmann, J., & Boeckers, T. M. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0881-z · Cited by 115 · see citing works

Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease.

Eugenin, E., Morgello, S., Klotman, M., Mosoian, A., Lento, P., Berman, J., & Schecter, A. (2008) · American Journal of Pathology · doi:10.2353/ajpath.2008.070457 · Cited by 109 · see citing works

Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance

Shibuya, Y., Chang, C. C. Y., Huang, L.-H., Bryleva, E. Y., & Chang, T.-Y. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2567-14.2014 · Cited by 108 · see citing works

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

Borjabad, A., Morgello, S., Chao, W., Kim, S.-Y., Brooks, A. I., Murray, J., Potash, M. J., & Volsky, D. J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002213 · Cited by 105 · see citing works

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

Hill, A. L., Rosenbloom, D. I. S., Goldstein, E., Hanhauser, E., Kuritzkes, D. R., Siliciano, R. F., & Henrich, T. J. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005535 · Cited by 102 · see citing works

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

Norman, J. P., Perry, S. W., Reynolds, H. M., Kiebala, M., Bentley, K. L. D. M., Trejo, M., Volsky, D. J., Maggirwar, S. B., Dewhurst, S., Masliah, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003731 · Cited by 101 · see citing works

Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease

Murphy, S. R., Chang, C. C. Y., Dogbevia, G., Bryleva, E. Y., Bowen, Z., Hasan, M. T., & Chang, T. (2013) · Molecular Therapy · doi:10.1038/mt.2013.118 · Cited by 100 · see citing works

HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?

Kulpa, D. A., & Chomont, N. (2015) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30490-8 · Cited by 97 · see citing works

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

Shibuya, Y., Niu, Z., Bryleva, E. Y., Harris, B. T., Murphy, S. R., Kheirollah, A., Bowen, Z. D., Chang, C. C. Y., & Chang, T. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.002 · Cited by 87 · see citing works

Cholesterol-mediated Neurite Outgrowth Is Differently Regulated between Cortical and Hippocampal Neurons

Ko, M., Zou, K., Minagawa, H., Yu, W., Gong, J.-S., Yanagisawa, K., & Michikawa, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509164200 · Cited by 87 · see citing works

Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing

Hearps, A. C., Martin, G. E., Rajasuriar, R., & Crowe, S. M. (2014) · Current HIV/AIDS Reports · doi:10.1007/s11904-013-0190-8 · Cited by 82 · see citing works

Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease

Levine, A. J., Miller, J. A., Shapshak, P., Gelman, B. B., Singer, E. J., Hinkin, C. H., Commins, D., Morgello, S., Grant, I., & Horvath, S. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-4 · Cited by 72 · see citing works

Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein

Gonzalez-Hernandez, M. J., Cavalcoli, J. D., Sartor, M. A., Contreras-Galindo, R., Meng, F., Dai, M., Dube, D., Saha, A. K., Gitlin, S. D., Omenn, G. S., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00556-14 · Cited by 72 · see citing works

The 3‐hydroxy‐3‐methylglutaryl co‐enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons

Pooler, A. M., Xi, S. C., & Wurtman, R. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03763.x · Cited by 72 · see citing works

ACAT inhibition and amyloid beta reduction

Bhattacharyya, R., & Kovacs, D. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.04.003 · Cited by 71 · see citing works

Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia

Cutler, R. G., Haughey, N. J., Tammara, A., McArthur, J. C., Nath, A., Reid, R., Vargas, D. L., Pardo, C. A., & Mattson, M. P. (2004) · Neurology · doi:10.1212/01.wnl.0000134662.19883.06 · Cited by 67 · see citing works

TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation

Lei, L., Xiong, Y., Chen, J., Yang, J.-B., Wang, Y., Yang, X., Chang, C. C. Y., Song, B., Chang, T., & Li, B.-L. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800484-jlr200 · Cited by 67 · see citing works

Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats

Repunte‐Canonigo, V., Lefèbvre, C., George, O., Kawamura, T., Morales, M., Koob, G. F., Califano, A., Masliah, E., & Sanna, P. P. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-26 · Cited by 65 · see citing works

Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration

Maisa, A., Hearps, A. C., Angelovich, T. A., Pereira, C. F., Zhou, J., Shi, M. D. Y., Palmer, C. S., Müller, W. A., Crowe, S. M., & Jaworowski, A. (2015) · AIDS · doi:10.1097/qad.0000000000000739 · Cited by 62 · see citing works

A lipid storage–like disorder contributes to cognitive decline in HIV-infected subjects

Bandaru, V. V. R., Mielke, M. M., Sacktor, N., McArthur, J. C., Grant, I., Letendre, S., Chang, L., Wojna, V., Pardo, C., Calabresi, P., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a9565e · Cited by 61 · see citing works

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity

Natarajaseenivasan, K., Cotto, B., Shanmughapriya, S., Lombardi, A. A., Datta, P. K., Madesh, M., Elrod, J. W., Khalili, K., & Langford, D. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0422-3 · Cited by 60 · see citing works

Ezetimibe Alone Reduces Low‐Density Lipoprotein Cholesterol in HIV‐Infected Patients Receiving Combination Antiretroviral Therapy

Wohl, D. A., Waters, D. D., Simpson, R. J., Richard, S., Schnell, A., Napravnik, S., Keys, J., Eron, J. J., & Hsue, P. Y. (2008) · Clinical Infectious Diseases · doi:10.1086/592116 · Cited by 57 · see citing works

Cocaine and HIV-1 Interplay: Molecular Mechanisms of Action and Addiction

Buch, S. J., Yao, H., Guo, M., Mori, T., Su, T., & Wang, J. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9297-0 · Cited by 55 · see citing works

Transcriptome analysis of monocyte-HIV interactions

den Bergh, R. V., Florence, É., Vlieghe, E., Boonefaes, T., Grooten, J., Houthuys, E., Tran, H. T. T., Gali, Y., BAETSELIER, P. D., Vanham, G., et al. (2010) · Retrovirology · doi:10.1186/1742-4690-7-53 · Cited by 54 · see citing works

Transcriptome Sequencing of Gene Expression in the Brain of the HIV-1 Transgenic Rat

Li, M. D., Cao, J., Wang, S., Wang, J., Sarkar, S., Vigorito, M., Ma, J. Z., & Chang, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059582 · Cited by 44 · see citing works

The Expression of Cholesterol Metabolism Genes in Monocytes From HIV-Infected Subjects Suggests Intracellular Cholesterol Accumulation

Feeney, E. R., McAuley, N., O’Halloran, J. A., Rock, C., Low, J., Satchell, C. S., Lambert, J. S., Sheehan, G. J., & Mallon, P. W. G. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis723 · Cited by 44 · see citing works

B cell lymphoma in hiv transgenic mice

Curreli, S., Krishnan, S., Reitz, M. S., Lunardi-Iskandar, Y., Lafferty, M. K., Demo, A. G., Zella, D., Gallo, R. C., & Bryant, J. (2013) · Retrovirology · doi:10.1186/1742-4690-10-92 · Cited by 40 · see citing works

Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors

Wu, J. Q., Sassé, T. R., Wolkenstein, G., Conceicao, V. N. D., Saksena, M. M., Soedjono, M., Perera, S. S., Wang, B., Dwyer, D. E., & Saksena, N. K. (2012) · Virology · doi:10.1016/j.virol.2012.10.026 · Cited by 39 · see citing works

Differential gene expression in HIV-infected individuals following ART

Massanella, M., Singhania, A., Beliakova‐Bethell, N., Pier, R., Lada, S. M., White, C., Pérez‐Santiago, J., Blanco, J., Richman, D. D., Little, S. J., et al. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.07.017 · Cited by 36 · see citing works

Hepatitis C virus infection mediates cholesteryl ester synthesis to facilitate infectious particle production

Read, S. A., Tay, E. S. E., Shahidi, M., George, J., & Douglas, M. W. (2014) · Journal of General Virology · doi:10.1099/vir.0.065300-0 · Cited by 36 · see citing works

Dysregulation of mitochondrial bioenergetics and quality control by HIV‐1 Tat in cardiomyocytes

Tahrir, F. G., Shanmughapriya, S., Ahooyi, T. M., Knezevic, T., Gupta, M. K., Kontos, C. D., McClung, J. M., Madesh, M., Gordon, J., Feldman, A. M., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26002 · Cited by 33 · see citing works

Global Mapping of the Macrophage-HIV-1 Transcriptome Reveals that Productive Infection Induces Remodeling of Host Cell DNA and Chromatin

Deshiere, A., Joly-Beauparlant, C., Breton, Y., Ouellet, M., Raymond, F., Lodge, R., Barat, C., Roy, M.-A., Corbeil, J., & Tremblay, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-05566-9 · Cited by 33 · see citing works

Targeting the latent reservoir to achieve functional HIV cure

Cary, D. C., & Peterlin, B. M. (2016) · F1000Research · doi:10.12688/f1000research.8109.1 · Cited by 31 · see citing works

Progression of temporal processing deficits in the HIV-1 transgenic rat

McLaurin, K. A., Booze, R. M., & Mactutus, C. F. (2016) · Scientific Reports · doi:10.1038/srep32831 · Cited by 31 · see citing works

Cocaine and HIV‐1 Tat disrupt cholesterol homeostasis in astrocytes: Implications for HIV‐associated neurocognitive disorders in cocaine user patients

Cotto, B., Natarajaseenivasan, K., Ferrero, K., Wesley, L., Sayre, M., & Langford, D. (2018) · Glia · doi:10.1002/glia.23291 · Cited by 30 · see citing works

HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum

Paydar, M. J., Roscoe, R. F., Denton, A. R., Mactutus, C. F., & Booze, R. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188404 · Cited by 30 · see citing works

Synaptodendritic injury with HIV-Tat protein: What is the therapeutic target?

Nath, A., & Steiner, J. P. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.11.004 · Cited by 28 · see citing works

Network analysis of hippocampal neurons by microelectrode array in the presence of HIV‐1 Tat and cocaine

Ahooyi, T. M., Shekarabi, M., Decoppet, E. A., Langford, D., Khalili, K., & Gordon, J. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26322 · Cited by 24 · see citing works

Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse

Lapierre, J., Rodriguez, M., Ojha, C. R., & El‐Hage, N. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9788-3 · Cited by 23 · see citing works

Unraveling Individual Differences In The HIV-1 Transgenic Rat: Therapeutic Efficacy Of Methylphenidate

McLaurin, K. A., Li, H., Booze, R. M., Fairchild, A. J., & Mactutus, C. F. (2018) · Scientific Reports · doi:10.1038/s41598-017-18300-2 · Cited by 17 · see citing works

Caspase-1-associated immune activation in an accelerated SIV-infected rhesus macaque model

Kearns, A. C., Robinson, J. A., Shekarabi, M., Liu, F., Qin, X., & Burdo, T. H. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0630-8 · Cited by 16 · see citing works

Selective developmental alterations in The HIV-1 transgenic rat: Opportunities for diagnosis of pediatric HIV-1

McLaurin, K. A., Booze, R. M., & Mactutus, C. F. (2016) · Journal of NeuroVirology · doi:10.1007/s13365-016-0476-x · Cited by 16 · see citing works

A transcriptome-based model of central memory CD4 T cell death in HIV infection

Olvera-García, G., Aguilar-García, T., Gutiérrez-Jasso, F., Imaz-Rosshandler, I., Rangel‐Escareño, C., Orozco, L., Aguilar-Delfín, I., Vázquez-Pérez, J. A., Zúñiga, J., Pérez-Patrigeón, S., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-3308-8 · Cited by 16 · see citing works

Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet

Xu, N., Meng, H., Liu, T., Feng, Y., Qi, Y., Zhang, D.-H., & Wang, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.122 · Cited by 12 · see citing works

HIV associated dementia: Role for neurosteroids

Perumal, M. B., & Dhanasekaran, S. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.02.008 · Cited by 6 · see citing works

Sustained Increase of HDL Cholesterol Over a 72-Week Period in HIV-Infected Patients Exposed to an Antiretroviral Regimen Including Lopinavir/Ritonavir

Meynard, J., Lacombe, K., Poirier, J., Massot, O., Lefebvre, B., Bouchaud, O., Guiard–Schmid, J., Martinez, A., Benlian, P., & Girard, P. (2008) · Journal of the International Association of Physicians in AIDS Care · doi:10.1177/1545109708326088 · Cited by 6 · see citing works

Lipid changes and tolerability in a cohort of adult HIV-infected patients who switched to rilpivirine/emtricitabine/tenofovir due to intolerance to previous combination ART: the PRO-STR study

Ocampo, A., Domingo, P., Fernández, P., Diz-Arén, J., Barberá, J. R., Sepúlveda, M. A., Salgado, X., Rodriguez, M., Santos, J., Yzusqui, M., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky175 · Cited by 4 · see citing works

Comorbidities of HIV infection

Sviridov, D., Mukhamedova, N., Makarov, A. А., Adzhubei, A. A., & Bukrinsky, M. (2019) · AIDS · doi:10.1097/qad.0000000000002385 · Cited by 66 · see citing works

Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation

Aksenova, M. V., Sybrandt, J., Cui, B., Sikirzhytski, V., Ji, H., Odhiambo, D. A., Lucius, M. D., Turner, J. R., Broude, E. V., Peña, E. A., et al. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09885-8 · Cited by 23 · see citing works

Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus

Cirino, T. J., Harden, S. W., McLaughlin, J. P., & Frazier, C. J. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00029.2020 · Cited by 26 · see citing works

Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects

Paris, J. J., Lière, P., Kim, S., Mahdi, F., Buchanan, M. E., Nass, S. R., Qrareya, A. N., Mohammed, S., Pianos, A., Fernandez, N., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100211 · Cited by 26 · see citing works

Alzheimer’s-Like Pathology at the Crossroads of HIV-Associated Neurological Disorders

Chemparthy, D. T., Kannan, M., Gordon, L., Buch, S. J., & Sil, S. (2021) · Vaccines · doi:10.3390/vaccines9080930 · Cited by 26 · see citing works

HIV-1 Tat Dysregulates the Hypothalamic-Pituitary-Adrenal Stress Axis and Potentiates Oxycodone-Mediated Psychomotor and Anxiety-Like Behavior of Male Mice

Mohammed, S., Mahdi, F., & Paris, J. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218212 · Cited by 24 · see citing works

Impact of native and external factors on exosome release: understanding reactive exosome secretion and its biogenesis

Hariharan, H. P., Kesavan, Y., & Sella, R. N. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06733-y · Cited by 21 · see citing works

HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status

Qrareya, A. N., Mahdi, F., Kaufman, M. J., Ashpole, N. M., & Paris, J. J. (2020) · GeroScience · doi:10.1007/s11357-020-00268-z · Cited by 19 · see citing works

Crossroads of Drug Abuse and HIV Infection: Neurotoxicity and CNS Reservoir

Sonti, S., Tyagi, K., Pande, A., Daniel, R., Sharma, A. L., & Tyagi, M. (2022) · Vaccines · doi:10.3390/vaccines10020202 · Cited by 17 · see citing works

Neuro‐HIV —New insights into pathogenesis and emerging therapeutic targets

Sviridov, D., & Bukrinsky, M. (2023) · The FASEB Journal · doi:10.1096/fj.202301239rr · Cited by 17 · see citing works

HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV

Cheng, Y., Jung, J., Guo, L., Shuboni-Mulligan, D. D., Chen, J.-F., Hu, W., & Guo, M.-L. (2025) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2024.09.011 · Cited by 16 · see citing works

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein

Torkzaban, B., Natarajaseenivasan, K., Ahooyi, T. M., Shekarabi, M., Amini, S., Langford, D., & Khalili, K. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03033-4 · Cited by 16 · see citing works

HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments

Zhao, X., Zhang, F., Kandel, S. R., Brau, F., & He, J. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110765 · Cited by 16 · see citing works

Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells

Ahooyi, T. M., Torkzaban, B., Shekarabi, M., Tahrir, F. G., Decoppet, E. A., Cotto, B., Langford, D., Amini, S., & Khalili, K. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1702-2 · Cited by 15 · see citing works

Pathophysiology and Clinical Management of Dyslipidemia in People Living with HIV: Sailing through Rough Seas

Papantoniou, E., Arvanitakis, K., Markakis, K., Papadakos, S. P., Tsachouridou, Ο., Popovic, D. S., Koufakis, T., Germanidis, G. S., & Kotsa, K. (2024) · Life · doi:10.3390/life14040449 · Cited by 14 · see citing works

Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

Qrareya, A. N., Mahdi, F., Kaufman, M. J., Ashpole, N. M., & Paris, J. J. (2022) · Aging · doi:10.18632/aging.204166 · Cited by 10 · see citing works

HIV-associated dyslipidemia: pathogenesis and its management

Wan, Z., Dai, B., Zhu, X., Huang, Y., & Zhu, B. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002879 · Cited by 11 · see citing works

HIV-1 and drug abuse comorbidity: Lessons learned from the animal models of NeuroHIV

Sil, S., Thangaraj, A., Chivero, E. T., Niu, F., Kannan, M., Liao, K., Silverstein, P. S., Periyasamy, P., & Buch, S. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135863 · Cited by 11 · see citing works

Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy

Mohammed, S., Qrareya, A. N., Mahdi, F., Moss, E. M., Akins, N. S., Li, J., Le, H. V., & Paris, J. J. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13047 · Cited by 8 · see citing works

Cross-talk between lipid homeostasis and endoplasmic reticulum stress in neurodegeneration: Insights for HIV-1 associated neurocognitive disorders (HAND)

Torkzaban, B., Ahooyi, T. M., Duggan, M. R., Amini, S., & Khalili, K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104880 · Cited by 8 · see citing works

Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids

Natarajaseenivasan, K., Garcia, A., Velusamy, P., Shanmughapriya, S., & Langford, D. (2022) · iScience · doi:10.1016/j.isci.2022.105407 · Cited by 6 · see citing works

HIV Tat Expression and Cocaine Exposure Lead to Sex- and Age-Specific Changes of the Microbiota Composition in the Gut

Li, L., Zhao, X., & He, J. J. (2023) · Microorganisms · doi:10.3390/microorganisms11030799 · Cited by 3 · see citing works

Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals

Guo, M., Cheng, Y., Pineda, D. M., Dempsey, R. E., & Yang, L. (2024) · Aging and Disease · doi:10.14336/ad.2024.0125 · Cited by 3 · see citing works

Investigating cocaine- and abstinence-induced effects on astrocyte gene expression in the nucleus accumbensPreprint

Franklin, J. P., Testen, A., Mieczkowski, P. A., Hepperla, A. J., Crynen, G. C., Simon, J. M., Wood, J., Harder, E. V., Bellinger, T. J., Witt, E. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.05.606656 · Cited by 1 · see citing works

Cocaine exacerbates neurological impairments and neuropathologies in the iTat model of HIV-associated neurocognitive disorder through genome-wide alterations of DNA methylation and gene expressionPreprint

Zhao, X., Zhang, F., Kandel, S. R., Brau, F., & He, J. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.22.469603

Chronic Cocaine Exposure Alters Genome-Wide DNA Methylation and Gene Expression and Exacerbates the Neurological Impairments and Neuropathologies in the Long-Term HIV Tat-Expressing Mouse Model of HIV Associated Neurocognitive DisorderPreprint

Zhao, X., Zhang, F., Kandel, S. R., Brau, F., & He, J. J. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3985171

Impairment of cholesterol homeostasis induced by Nef-containing extracellular vesicles as a factor in HAND pathogenesis

Bukrinsky, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00037-7

The role of HIV-associated neuroendocrine dysfunction in HAND

Paris, J. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00006-7

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells is associated with neuroinflammatory signaling in antiretroviral treated SIV-infected rhesus macaques

Acharya, A., Ambikan, A. T., Neogi, U., Lamberty, B. G., Callen, S. E., Buch, S. J., Fox, H. S., & Byrareddy, S. N. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03801-7

Cocaine and HIV‐1 Tat disrupt cholesterol homeostasis in astrocytes: Implications for HIV‐associated neurocognitive disorders in cocaine user patients

Cotto, B., Natarajaseenivasan, K., Ferrero, K., Wesley, L., Sayre, M., & Langford, D. (2018) · Glia · doi:10.1002/glia.23291 · Cited by 30 · see citing works

Cocaine and HIV-1 Tat Alter Astrocyte Energetics and Essential Neuronal Substrate Supply

Cotto, B. (2019) · TUScholarShare (Temple University)

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein

(2020) · TUScholarShare (Temple University) · doi:10.34944/dspace/4630

HIV-1 Tat and Cocaine Impair Survival of Cultured Primary Neuronal Cells via a Mitochondrial Pathway

Simone, F. I. D., Darbinian, N., Amini, S., Madesh, M., White, M. K., Elrod, J. W., Datta, P. K., Langford, D., & Khalili, K. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9669-6 · Cited by 40 · see citing works

Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat

Wayman, W. N., Dodiya, H. B., Persons, A. L., Kashanchi, F., Kordower, J. H., Hu, X., & Napier, T. C. (2012) · Neuroreport · doi:10.1097/wnr.0b013e3283578050 · Cited by 26 · see citing works