The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry
Open accessAbstract
To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. Here we report that IFN prevents emergence of viral genomes from the endosomal pathway, and that IFITM3 is both necessary and sufficient for this function. Notably, viral pseudoparticles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. We further demonstrate that IFN expands Rab7 and LAMP1-containing structures, and that IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses. Collectively our data are consistent with the prediction that viruses that fuse in the late endosomes or lysosomes are vulnerable to IFITM3's actions, while viruses that enter at the cell surface or in the early endosomes may avoid inhibition. Multiple viruses enter host cells through the late endocytic pathway, and many of these invaders are attenuated by IFN. Therefore these findings are likely to have significance for the intrinsic immune system's neutralization of a diverse array of threats.
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Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578
Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252
Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057
TRIM5 is an innate immune sensor for the retrovirus capsid lattice
Pertel, T., Hausmann, S., Morger, D., Züger, S., Guerra, J., Lascano, J., Reinhard, C., Santoni, F. A., Uchil, P. D., Chatel, L., et al. (2011) · Nature · doi:10.1038/nature09976 · Cited by 645
Self-citation(1998) · The Lancet · doi:10.1016/s0140-6736(98)10190-3 · Cited by 351
Lawe, D. C., Chawla, A., Merithew, E., Dumas, J., Carrington, W., Fogarty, K., Lifshitz, L., Tuft, R., Lambright, D., & Corvera, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109239200 · Cited by 156
Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
Savidis, G., McDougall, W. M., Meraner, P., Perreira, J. M., Portmann, J. M., Trincucci, G., John, S. P., Aker, A. M., Renzette, N., Robbins, D. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.028 · Cited by 363
Self-citationIFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread
Compton, A. A., Bruel, T., Porrot, F., Mallet, A., Sachse, M., Euvrard, M., Liang, C., Casartelli, N., & Schwartz, O. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.11.001 · Cited by 231
Hwang, Y., Kim, J., Shin, J.-Y., Kim, J.-I., Seo, J.-S., Webster, M. J., Lee, D., & Kim, S. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.94 · Cited by 189
Chin, C. R., Perreira, J. M., Savidis, G., Portmann, J. M., Aker, A. M., Feeley, E. M., Smith, M. C., & Brass, A. L. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.036 · Cited by 166
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Metadata
- Authors
- Feeley, E. M., Sims, J. S., John, S. P., Chin, C. R., Pertel, T., Chen, L.-M., Gaiha, G. D., Ryan, B. J., Donis, R. O., Elledge, S. J., & Brass, A. L.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-10-27
- Volume
- 7
- Issue
- 10
- Pages
- e1002337
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2048648611
- Cited by
- 387
- References
- 6
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Feeley, E. M., Sims, J. S., John, S. P., Chin, C. R., Pertel, T., Chen, L.-M., Gaiha, G. D., Ryan, B. J., Donis, R. O., Elledge, S. J., & Brass, A. L. (2011). IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1002337
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