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Vaccines for Gonorrhea: Can We Rise to the Challenge?

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S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages

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S100 Proteins in the Innate Immune Response to Pathogens

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PerR controls Mn‐dependent resistance to oxidative stress inNeisseria gonorrhoeae

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The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence

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Neisseria gonorrhoeae Evades Calprotectin-Mediated Nutritional Immunity and Survives Neutrophil Extracellular Traps by Production of TdfH

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Neisseria gonorrhoeae requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells

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Commentary

Bloomfield, P. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.06.013 · Cited by 58 · see citing works

The Zinc-Responsive Regulon of Neisseria meningitidis Comprises 17 Genes under Control of a Zur Element

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The fbpABC Operon Is Required for Ton-Independent Utilization of Xenosiderophores by Neisseria gonorrhoeae Strain FA19

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Gonococcal Defenses against Antimicrobial Activities of Neutrophils

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Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue

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New Complementation Constructs for Inducible and Constitutive Gene Expression in Neisseria gonorrhoeae and Neisseria meningitidis

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Subversion of nutritional immunity by the pathogenic Neisseriae

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Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract

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Fur-Mediated Activation of Gene Transcription in the Human Pathogen Neisseria gonorrhoeae

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Dual Zinc Transporter Systems in Vibrio cholerae Promote Competitive Advantages over Gut Microbiome

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Neisserial TonB-dependent outer-membrane proteins: detection, regulation and distribution of three putative candidates identified from the genome sequences The GenBank accession number for the sequence of tdfH from meningococcal strain IR1074 reported in this paper is AF227418.

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Structural insight into the lactoferrin receptors from pathogenic Neisseria

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Identification and characterization of a high-affinity zinc uptake system in Neisseria gonorrhoeae

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The Neisseria meningitidis ZnuD Zinc Receptor Contributes to Interactions with Epithelial Cells and Supports Heme Utilization when Expressed in Escherichia coli

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Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis

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Demonstration and Characterization of a Specific Interaction between Gonococcal Transferrin Binding Protein A and TonB

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The Mouse S100A15 Ortholog Parallels Genomic Organization, Structure, Gene Expression, and Protein-Processing Pattern of the Human S100A7/A15 Subfamily During Epidermal Maturation

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Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin)

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ZnuD, a Potential Candidate for a Simple and Universal Neisseria meningitidis Vaccine

Hubert, K., Devos, N., Mordhorst, I., Tans, C., Baudoux, G., Feron, C., Goraj, K., Tommassen, J., Vogel, U., Poolman, J. T., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01312-12 · Cited by 28 · see citing works

Commentary

Maldonado, N. G., & Takhar, S. S. (2012) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2012.10.015 · Cited by 27 · see citing works

Beyond the Crystal Structure: Insight into the Function and Vaccine Potential of TbpA Expressed by Neisseria gonorrhoeae

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S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureusdetection

Andresen, E., Lange, C. G., Strodthoff, D., Goldmann, T., Fischer, N., Sahly, H., Branscheid, D., & Heine, H. (2011) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-11-10 · Cited by 22 · see citing works

PubMed Central (PMC)

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Neisseria gonorrhoeae and humans perform an evolutionary LINE dance

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Vaccines for Gonorrhea: Can We Rise to the Challenge?

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Characterization of the Effects of Iron on Neisseria Gonorrhoeae Surface Protein Modulation and Host Cell Interactions

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Characterization of TonB-Dependent Metal Transporters within Neisseria gonorrhoeae

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DRUG AND VACCINE DEVELOPMENT FOR NEISSERIA GONORRHOEAEA

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Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

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Regulation of zinc-dependent enzymes by metal carrier proteins

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Neisseria gonorrhoeae vaccines: a contemporary overview

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The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis

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Recent Progress Towards a Gonococcal Vaccine

Maurakis, S. A., & Cornelissen, C. N. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.881392 · Cited by 37 · see citing works

Diisonitrile Lipopeptides Mediate Resistance to Copper Starvation in Pathogenic Mycobacteria

Buglino, J. A., Ozakman, Y., Xu, Y., Chowdhury, F., Tan, D. S., & Glickman, M. S. (2022) · mBio · doi:10.1128/mbio.02513-22 · Cited by 31 · see citing works

Structural Basis for Evasion of Nutritional Immunity by the Pathogenic Neisseriae

Yadav, R., Noinaj, N., Ostan, N., Moraes, T. F., Stoudenmire, J. L., Maurakis, S. A., & Cornelissen, C. N. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02981 · Cited by 27 · see citing works

Integrated Bioinformatic Analyses and Immune Characterization of New Neisseria gonorrhoeae Vaccine Antigens Expressed during Natural Mucosal Infection

Zhu, T., McClure, R., Harrison, O. B., Genco, C. A., & Massari, P. (2019) · Vaccines · doi:10.3390/vaccines7040153 · Cited by 25 · see citing works

Molecular Insight into TdfH-Mediated Zinc Piracy from Human Calprotectin by Neisseria gonorrhoeae

Kammerman, M. T., Bera, A. K., Wu, R., Harrison, S., Maxwell, C. N., Lundquist, K. P., Noinaj, N., Chazin, W., & Cornelissen, C. N. (2020) · mBio · doi:10.1128/mbio.00949-20 · Cited by 23 · see citing works

Clinical and genomic analysis of virulence-related genes in bloodstream infections caused by Acinetobacter baumannii

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Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae

Branch, A. H., Stoudenmire, J. L., Seib, K. L., & Cornelissen, C. N. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.909888 · Cited by 17 · see citing works

IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube

Garcia, E. M., Lenz, J. D., Schaub, R. E., Hackett, K. T., Salgado‐Pabón, W., & Dillard, J. P. (2024) · Nature Communications · doi:10.1038/s41467-024-48141-3 · Cited by 19 · see citing works

Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity

Kelliher, J. L., Brazel, E. B., Radin, J. N., Joya, E. S., Solórzano, P. K. P., Neville, S. L., McDevitt, C. A., & Kehl‐Fie, T. E. (2020) · Infection and Immunity · doi:10.1128/iai.00102-20 · Cited by 12 · see citing works

Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

Stoudenmire, J. L., Greenawalt, A. N., & Cornelissen, C. N. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1017348 · Cited by 12 · see citing works

Adjuvant-dependent impacts on vaccine-induced humoral responses and protection in preclinical models of nasal and genital colonization by pathogenic Neisseria

Islam, E. A., Fegan, J. E., Zeppa, J. J., Ahn, S. K., Ng, D., Currie, E. G., Lam, J., Moraes, T. F., & Gray‐Owen, S. D. (2024) · Vaccine · doi:10.1016/j.vaccine.2025.126709 · Cited by 11 · see citing works

Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity

Liyayi, I. K., Forehand, A. L., Ray, J. C., & Criss, A. K. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011091 · Cited by 8 · see citing works

Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae

Fegan, J. E., Islam, E. A., Curran, D. M., Ng, D., Au, N. H., Currie, E. G., Zeppa, J. J., Lam, J., Schryvers, A. B., Moraes, T. F., et al. (2025) · npj Vaccines · doi:10.1038/s41541-024-01054-0 · Cited by 11 · see citing works

Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands

Maurakis, S. A., & Cornelissen, C. N. (2020) · Journal of Visualized Experiments · doi:10.3791/60903 · Cited by 9 · see citing works

Transcriptional and Translational Responsiveness of the Neisseria gonorrhoeae Type IV Secretion System to Conditions of Host Infections

Callaghan, M. M., Klimowicz, A. K., Shockey, A. C., Kane, J., Pepperell, C. S., & Dillard, J. P. (2021) · Infection and Immunity · doi:10.1128/iai.00519-21 · Cited by 9 · see citing works

Point Mutations in TbpA Abrogate Human Transferrin Binding in Neisseria gonorrhoeae

Greenawalt, A. N., Stoudenmire, J. L., Lundquist, K. P., Noinaj, N., Gumbart, J. C., & Cornelissen, C. N. (2022) · Infection and Immunity · doi:10.1128/iai.00414-22 · Cited by 8 · see citing works

Macrophage-Mediated Defensive Mechanisms Involving Zinc Homeostasis in Bacterial Infection

Na-Phatthalung, P., Min, J., & Wang, F. (2021) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000058 · Cited by 8 · see citing works

Temporal modelling of the biofilm lifecycle (TMBL) establishes kinetic analysis of plate-based bacterial biofilm dynamics

Enriquez, K. T., Plummer, W. D., Neufer, P. D., Chazin, W., Dupont, W. D., & Skaar, E. P. (2023) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2023.106808 · Cited by 7 · see citing works

Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins

Ray, J. C., Smirnov, A., Maurakis, S. A., Harrison, S., Ke, E., Chazin, W., Cornelissen, C. N., & Criss, A. K. (2022) · Infection and Immunity · doi:10.1128/iai.00009-22 · Cited by 7 · see citing works

Multifaceted Role of Copper Homeostasis in Gut Health: From Molecular Mechanisms to Therapeutic Interventions

Lu, F., Wang, X., Xue, X., Liu, L. Z., Li, D., Liu, A. F., Qin, S., & Liu, L. (2026) · Cells · doi:10.3390/cells15060545 · Cited by 6 · see citing works

Comparative analysis of the physical properties of murine and human S100A7: Insight into why zinc piracy is mediated by human but not murine S100A7

Harrison, S., Naretto, A., Balakrishnan, S., Perera, Y. R., & Chazin, W. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105292 · Cited by 6 · see citing works

Mutagenesis of the Loop 3 α-Helix of Neisseria gonorrhoeae TdfJ Inhibits S100A7 Binding and Utilization

Maurakis, S. A., Stoudenmire, J. L., Rymer, J. K., Chazin, W., & Cornelissen, C. N. (2022) · mBio · doi:10.1128/mbio.01670-22 · Cited by 4 · see citing works

The C‐terminal extension of calprotectin mediates zinc chelation and modulates Staphylococcus aureus biomass accumulation

Perera, Y. R., Enriquez, K. T., Rodriguez, A., Garcia, V., Akizuki, T., Naretto, A., Togashi, M., Guillen, R., Skaar, E. P., & Chazin, W. (2025) · Protein Science · doi:10.1002/pro.70294 · Cited by 4 · see citing works

Immunoinformatics Prediction of an Epitope Based Peptide Vaccine for Neisseria Gonorrhea Dihydrolipoamide Acetyltransferase ProteinPreprint

Elhag, M., Sati, A. O. M., Abdelmoneim, A. H., Saadaldin, M. M., Taha, T. S., & Hassan, M. A. (2021) · Preprints.org · doi:10.20944/preprints202101.0141.v1 · Cited by 3 · see citing works

Neisseria gonorrhoeae antimicrobial susceptibility testing: application of traditional agar dilution to a high-throughput 96-well microtiter assay

Kuipers, J. E., Seidel, L., Garnier, N. E., & Khursigara, C. M. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.03249-24 · Cited by 2 · see citing works

A periplasmic zinc capture protein enhances the resistance of Neisseria gonorrhoeae to nutritional immunity

Liyayi, I. K., Bera, A. K., Perera, Y. R., Ferdausi, N., Bhatia, I., Noinaj, N., Chazin, W., Cornelissen, C. N., & Criss, A. K. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426176122 · Cited by 2 · see citing works

The Neisseria meningitidis iron acquisition protein HpuA moonlights as an adhesin and inhibits host cell migrationPreprint

Shortt, G., Ren, X., Otto, B. M., & MacKichan, J. K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.25.481912 · Cited by 2 · see citing works

Dual species transcriptomics reveals core metabolic and immunologic processes in the interaction between primary human neutrophils and Neisseria gonorrhoeae strainsPreprint

Edwards, V. L., Potter, A. D., D’Mello, A., Gray, M. C., Shetty, A. C., Zhao, X., Hill, K. M., Ragland, S. A., Criss, A. K., & Tettelin, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.28.482360 · Cited by 2 · see citing works

IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tubePreprint

Garcia, E. M., Lenz, J. D., Hackett, K. T., Salgado‐Pabón, W., & Dillard, J. P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.28.518270 · Cited by 2 · see citing works

Characterizing the dual regulation of Neisseria gonorrhoeae tdfJ in response to zinc and ironPreprint

Padmanabhan, S., Stoudenmire, J. L., Branch, A. H., & Cornelissen, C. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.01.606247 · Cited by 2 · see citing works

Bacterial Nutrient Acquisition and Its Function in Diseases

Soni, V., & Upadhyay, A. (2026) · Springer eBooks · doi:10.1007/978-3-031-46895-7_5 · Cited by 1 · see citing works

Investigating the importance of selected surface-exposed loops in HpuB for hemoglobin binding and utilization by Neisseria gonorrhoeae

Awate, O. A., Ng, D., Stoudenmire, J. L., Moraes, T. F., & Cornelissen, C. N. (2024) · Infection and Immunity · doi:10.1128/iai.00211-24 · Cited by 1 · see citing works

S100 Proteins

Heizmann, C. W. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_225 · Cited by 1 · see citing works

S100 Proteins

Heizmann, C. W. (2021) · Springer eBooks · doi:10.1007/978-3-030-21573-6_225-2 · Cited by 1 · see citing works

Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against Neisseria gonorrhoeaePreprint

Fegan, J. E., Islam, E. A., Curran, D. M., Ng, D., Au, N., Currie, E. G., Zeppa, J. J., Lam, J., Schryvers, A. B., Moraes, T. F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.07.611798 · Cited by 1 · see citing works

S100 Proteins

Heizmann, C. W. (2020) · Springer eBooks · doi:10.1007/978-3-030-21573-6_225-1

Investigating the importance of surface exposed loops in the gonococcal HpuB transporter for hemoglobin binding and utilizationPreprint

Awate, O. A., Ng, D., Stoudenmire, J. L., Moraes, T. F., & Cornelissen, C. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.30.564842

Structural insights into zinc piracy by Neisseria gonorrhoeae to overcome nutritional immunity

Gheinani, P. T., Bera, A., Stoudenmire-Saylor, J., Lien, Y., Harrison, S. A., Criss, A., Chazin, W. J., Noinaj, N., & Cornelissen, C. N. (2025) · Structure · doi:10.1016/j.str.2025.11.014

Neisseria gonorrhoeae: mechanisms of immune evasion, antimicrobial resistance, and vaccine development challenges

Onofrio, I., & MacLennan, C. A. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1824540

Alternative ribosomal protein RpmE2 is produced under zinc limitation in Neisseria gonorrhoeae and slows translation and bacterial growth

Forehand, A. L., Malezyna, K., Thomas, K. S., Glomski, I. J., Cornelissen, C. N., Jomaa, A., & Criss, A. K. (2026) · mBio · doi:10.1128/mbio.01137-26

Study Progress on Pseudomonas plecoglossicida—Virulence Factors, Prevention and Control Methods, and Interaction with Host

Chen, L., Wang, J., Ma, X., Yanling, Y., 林位琅, Qian, H., & Zhuang, Z. (2026) · Toxins · doi:10.3390/toxins18110463

Characterization of the Novel Interaction Between Neisseria gonorrhoeae TdfJ and its Human Ligand S100A7

Maurakis, S. A. (2019) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/hx8b-cj32

Mutagenesis of the Loop 3 α-Helix of Neisseria gonorrhoeae TdfJ Inhibits S100A7 Binding and Utilization

Maurakis, S. A., Stoudenmire, J. L., Rymer, J. K., Chazin, W., & Cornelissen, C. N. (2022) · mBio · doi:10.1128/mbio.01670-22 · Cited by 4 · see citing works

Functional and Immune Characterization of the Gonococcal Zinc Importer TdfJ

Maurakis, S. A. (2023) · Digital Archive @ GSU · doi:10.57709/31312707 · Cited by 1 · see citing works

Resistance of Neisseria gonorrhoeae to nutritional immunity protein-mediated zinc limitation during epithelial infection

Ray, J. C. (2022) · Libra · doi:10.18130/8wwf-zz20

Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins

Ray, J. C., Smirnov, A., Maurakis, S. A., Harrison, S., Ke, E., Chazin, W., Cornelissen, C. N., & Criss, A. K. (2022) · Infection and Immunity · doi:10.1128/iai.00009-22 · Cited by 7 · see citing works