The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Differential Gene Expression of Eph Receptors and Ephrins in Benign Human Tissues and Cancers
Abstract
Background: Eph receptors and their ligands, the ephrins, represent a large class of cell–cell communication molecules with well-defined developmental functions. Their role in healthy adult tissues and in human disease is still largely unknown, although diverse roles in carcinogenesis have been postulated. Methods: We established a set of fluorescent PCR probes and primers for the definition of individual gene expression profiles of 12 different Eph receptors and 8 ephrins in 13 different healthy tissues. The mRNA expression profiles were studied in human lung, colorectal, kidney, liver, and brain cancers. Results: The family of Eph receptors/ephrins was widely expressed in adult tissues with organ-site-specific patterns: EphB6 was highest in the thymus, compatible with an involvement in T-cell maturation. Brain and testis shared a unique pattern with EphA6, EphA8, and EphB1 being the most prominent. EphA7 had a high abundance in the kidney vasculature. Ephrin-A3 was up-regulated 26-fold in lung cancer, and EphB2 was up-regulated 9-fold in hepatocellular carcinoma. EphA8 was down-regulated in colon cancer, and EphA1/EphA8 was down-regulated in glioblastomas. Conclusion: Eph/Ephrin genes are widely expressed in all adult organs with certain organ-site-specific patterns. Because their function in adult tissues remains unknown, further analysis of their role in disease may disclose new insights beyond their well-defined meaning in development.
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The ephrins and Eph receptors in angiogenesis
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Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo
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Cited by
Miao, H., Li, D.-Q., Mukherjee, A., Guo, H., Petty, A., Cutter, J., Basilion, J. P., Sedor, J., Wu, J., Danielpour, D., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.04.009 · Cited by 533
The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors: Function and Therapeutic Targeting
Wykosky, J., & Debinski, W. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0244 · Cited by 300
Dependence receptors: a new paradigm in cell signaling and cancer therapy
Goldschneider, D., & Mehlen, P. (2010) · Oncogene · doi:10.1038/onc.2010.13 · Cited by 169
Nissinen, L., Farshchian, M., Riihilä, P., & Kähäri, V.-M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2457-z · Cited by 80
Metadata
- Authors
- Hafner, C., Schmitz, G., Meyer, S., Bataille, F., Hau, P., Langmann, T., Dietmaier, W., Landthaler, M., & Vogt, T.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-01
- Volume
- 50
- Issue
- 3
- Pages
- 490-499
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2105912939
- Cited by
- 323
- References
- 32
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hafner, C., Schmitz, G., Meyer, S., Bataille, F., Hau, P., Langmann, T., Dietmaier, W., Landthaler, M., & Vogt, T. (2004). Differential Gene Expression of Eph Receptors and Ephrins in Benign Human Tissues and Cancers. Clinical Chemistry. https://doi.org/10.1373/clinchem.2003.026849
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