Cited by 172Gout, Hyperuricemia, Uric AcidDiet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

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Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community

Chien, Kuo-Liong, Chen, Ming-Fong, Hsu, Hsiu-Ching, Chang, Wei-Tien, Su, Ta-Chen, Lee, Yuan-Teh, Hu, Frank B·2008·Clinical Chemistry

DOI 10.1373/clinchem.2007.095190

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Abstract

BACKGROUND: Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals. METHODS: We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes. RESULTS: High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20-2.23; P for trend <0.001]. After additional adjustment for metabolic syndrome, the RR for comparing the participants in the fifth and first uric acid quintiles was 1.40 (95% CI, 1.02-1.92; P for trend = 0.027). In joint analyses, participants who were in the highest uric acid quintile and also had metabolic syndrome had a 3.3-fold greater risk of diabetes (95% CI, 2.27-4.94) than those in the lowest uric acid quintile and without metabolic syndrome. CONCLUSIONS: These findings suggest a modest positive association between plasma uric acid concentration and the incidence of type 2 diabetes in Chinese individuals. The association between hyperuricemia and diabetes was partly mediated through the metabolic syndrome.

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Authors: Chien, K.-L., Chen, M.-F., Hsu, H.-C., Chang, W.-T., Su, T.-C., Lee, Y.-T., & Hu, F. B.
Affiliations: Harvard University (US)
National Taiwan University Hospital (TW)
Corresponding author: Lee, Yuan-Teh
Hu, Frank B
ORCID: Chien, Kuo-Liong
Chang, Wei-Tien
Su, Ta-Chen
Hu, Frank B
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2008-02-01
Volume: 54
Issue: 2
Pages: 310-316
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2007.095190
OpenAlex: W2149640217
Cited by: 172
References: 40
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 6 · 2014: 11 · 2013: 14 · 2012: 13
FWCI: 7.54
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor, 4359 d)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council
American Heart Association
Topics: Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: plasma uric acid, hyperuricemia, type 2 diabetes, diabetes incidence, metabolic syndrome, Chinese population, prospective cohort
MeSH terms: Adult, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Taiwan, Uric Acid, Biomarkers, Multivariate Analysis, Asian People

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Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community

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