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Cited by 181

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer

Menendez, Javier A, Vazquez-Martin, Alejandro, Ortega, Francisco Jose, Fernandez-Real, Jose Manuel·2009·Clinical Chemistry
DOI 10.1373/clinchem.2008.115352
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Abstract

Background: An emerging paradigm supports the notion that deregulation of fatty acid synthase (FASN)-catalyzed de novo FA biogenesis could play a central role in the pathogenesis of metabolic diseases sharing the hallmark of insulin-resistance. Content: We reviewed pharmacological and genetic alterations of FASN activity that have been shown to significantly influence energy expenditure rates, fat mass, insulin sensitivity, and cancer risk. This new paradigm proposes that insulin-resistant conditions such as obesity, type 2 diabetes, and cancer arise from a common FASN-driven “lipogenic state”. An important question then is whether the development or the progression of insulin-related metabolic disorders can be prevented or reversed by the modulation of FASN status. If we accept the paradigm of FASN dysfunction as a previously unrecognized link between insulin resistance, type 2 diabetes, and cancer, the use of insulin sensitizers in parallel with forthcoming FASN inhibitors should be a valuable therapeutic approach that, in association with lifestyle interventions, would concurrently improve energy-flux status, ameliorate insulin sensitivity, and alleviate the risk of lipogenic carcinomas. Conclusions: Although the picture is currently incomplete and researchers in the field have plenty of work ahead, the latest clinical and experimental evidence that we discuss illuminates a functional and drug-modifiable link that connects FASN-driven endogenous FA biosynthesis, insulin action, and glucose homeostasis in the natural history of insulin-resistant pathologies.

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Metadata

Authors
Menendez, J. A., Vazquez-Martin, A., Ortega, F. J., & Fernandez-Real, J. M.
Venue
Clinical Chemistry
Publisher
Oxford University Press (OUP)
Published
2009-03-01
Volume
55
Issue
3
Pages
425-438
ISSN
  • 0009-9147 (ISSN-L)
  • 1530-8561
DOI
10.1373/clinchem.2008.115352
OpenAlex
W2135004013
Cited by
181
References
10
FWCI
4.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer. https://app.cochat.ai/papers/10.1373/clinchem.2008.115352
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Menendez, J. A., Vazquez-Martin, A., Ortega, F. J., & Fernandez-Real, J. M. (2009). Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer. Clinical Chemistry. https://doi.org/10.1373/clinchem.2008.115352

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.