Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults

Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works

Physical Status: The Use and Interpretation of Anthropometry

Frisancho, A. R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.830 · Cited by 6,621 · see citing works

Prevalence and trends in obesity among US adults, 1999–2000

Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190 · see citing works

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866 · see citing works

Actual causes of death in the United States

McGinnis, J. M. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510180077038 · Cited by 5,480 · see citing works

Actual Causes of Death in the United States, 2000

Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211 · see citing works

Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.

(1998) · Obesity Research · doi:10.1037/e565682010-001 · Cited by 4,339 · see citing works

Banting lecture 1988. Role of insulin resistance in human disease.

Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801 · see citing works

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,283 · see citing works

Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

Lagergren, J., Bergström, R., Lindgren, A., & Nyrén, O. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903183401101 · Cited by 3,012 · see citing works

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome

Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961 · see citing works

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,761 · see citing works

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer

Calle, E. E., Heath Jr., C. W., Coates, R. J., Liff, J. M., Franceschi, S., Talamini, R., Chantarakul, N., Koetsawang, S., Rachawat, D., Morabia, A., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)08233-0 · Cited by 2,450 · see citing works

Global strategy on diet, physical activity and health

Samuelson, G. (2004) · Food & Nutrition Research · doi:10.3402/fnr.v48i2.1503 · Cited by 2,322 · see citing works

Obesity and the Environment: Where Do We Go from Here?

Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180 · see citing works

Changing patterns in the incidence of esophageal and gastric carcinoma in the United States

Devesa, S. S., Blot, W. J., & Fraumeni, J. F. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10 · Cited by 2,096 · see citing works

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

Chan, J. M., Stampfer, M. J., Giovannucci, E. L., Gann, P. H., Ma, J., Wilkinson, P., Hennekens, C. H., & Pollak, M. (1998) · Science · doi:10.1126/science.279.5350.563 · Cited by 1,992 · see citing works

American Cancer Society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity

Kushi, L. H., Byers, T., Doyle, C., Bandera, E. V., McCullough, M., Gansler, T., Andrews, K. S., Thun, M. J., & The American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee (2006) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.5.254 · Cited by 1,901 · see citing works

Annual Deaths Attributable to Obesity in the United States

Allison, D. B. (1999) · JAMA · doi:10.1001/jama.282.16.1530 · Cited by 1,868 · see citing works

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B. J., ROSNER, B. A., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,822 · see citing works

Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies

The Endogenous Hormones and Breast Cancer Collaborative Group (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.8.606 · Cited by 1,793 · see citing works

Use and misuse of population attributable fractions

Rockhill, B., Newman, B., & Weinberg, C. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.1.15 · Cited by 1,683 · see citing works

Nutritional Regulation of the Insulin-Like Growth Factors*

Thissen, J., Ketelslegers, J., & Underwood, L. E. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-80 · Cited by 1,578 · see citing works

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259 · see citing works

Pathophysiology of insulin resistance in human disease

Reaven, G. M. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.473 · Cited by 1,235 · see citing works

The worldwide obesity epidemic

James, P. T., Leach, R., Kalamara, E., & Shayeghi, M. (2001) · Obesity Research · doi:10.1038/oby.2001.123 · Cited by 1,201 · see citing works

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,190 · see citing works

Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. Writing Group for the Women's Health Initiative Investigators. JAMA 2002; 288(3): 321-333

Gebbie, A. E. (2002) · Journal of Family Planning and Reproductive Health Care · doi:10.1783/147118902101196685 · Cited by 1,178 · see citing works

Variations in mortality by weight among 750,000 men and women

Lew, E. A., & Garfinkel, L. (1979) · Journal of Chronic Diseases · doi:10.1016/0021-9681(79)90119-x · Cited by 1,175 · see citing works

The insulin-like growth factor system and cancer

LeRoith, D., & Roberts, C. T. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00159-9 · Cited by 1,124 · see citing works

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.620 · Cited by 1,118 · see citing works

Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women

Endogenous Hormones Breast Cancer Collaborative Group (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg022 · Cited by 1,093 · see citing works

PKB/Akt

Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,071 · see citing works

Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk

Schairer, C. (2000) · JAMA · doi:10.1001/jama.283.4.485 · Cited by 1,046 · see citing works

Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.

Kaaks, R., Lukanova, A., & Kurzer, M. S. (2002) · PubMed · Cited by 1,038 · see citing works

Physical Activity, Obesity, and Risk for Colon Cancer and Adenoma in Men

Giovannucci, E. L., Ascherio, A., Rimm, E. B., Colditz, G. A., Stampfer, M. J., & Willett, W. C. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-5-199503010-00002 · Cited by 1,011 · see citing works

The Effects Of Obesity, Smoking, And Drinking On Medical Problems And Costs

Sturm, R. (2002) · Health Affairs · doi:10.1377/hlthaff.21.2.245 · Cited by 987 · see citing works

Dual Effects of Weight and Weight Gain on Breast Cancer Risk

Huang, Z., Hankinson, S. E., Colditz, G. A., Stampfer, M. J., Hunter, D. J., Manson, J. E., Hennekens, C. H., ROSNER, B. A., Speizer, F. E., & Willett, W. C. (1997) · JAMA · doi:10.1001/jama.1997.03550170037029 · Cited by 948 · see citing works

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854 · see citing works

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

Khandwala, H. M., McCutcheon, I. E., Flyvbjerg, A., & Friend, K. E. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.3.0399 · Cited by 842 · see citing works

The Insulin-Related Ovarian Regulatory System in Health and Disease

Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 839 · see citing works

Insulin and colon cancer

Giovannucci, E. L. (1995) · Cancer Causes & Control · doi:10.1007/bf00052777 · Cited by 801 · see citing works

Insulin Resistance — Mechanisms, Syndromes, and Implications

Epstein, F. H., Moller, D. E., & Flier, J. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251307 · Cited by 800 · see citing works

Overweight as an avoidable cause of cancer in Europe

Bergström, A., Pisani, P., Tenet, V., Wolk, A., & Adami, H. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(200002)9999:9999 · Cited by 772 · see citing works

Hormonal Etiology of Epithelial Ovarian Cancer, With a Hypothesis Concerning the Role of Androgens and Progesterone

Risch, H. A. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.23.1774 · Cited by 771 · see citing works

Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis

Everhart, J. (1995) · JAMA · doi:10.1001/jama.273.20.1605 · Cited by 747 · see citing works

IARC Handbooks of Cancer Prevention

Feig, S. A. (2003) · Cancer · doi:10.1002/cncr.11334 · Cited by 745 · see citing works

Criteria for definition of overweight in transition: background and recommendations for the United States

Kuczmarski, R. J., & Flegal, K. M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1074 · Cited by 705 · see citing works

Obesity, Hypertension, and the Risk of Kidney Cancer in Men

Chow, W., Gridley, G., Fraumeni, J. F., & Järvholm, B. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011023431804 · Cited by 667 · see citing works

Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer

Michaud, D. S. (2001) · JAMA · doi:10.1001/jama.286.8.921 · Cited by 663 · see citing works

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

Kaaks, R. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.19.1592 · Cited by 655 · see citing works

Cancer Incidence in a Population-Based Cohort of Patients Hospitalized With Diabetes Mellitus in Denmark

Wideroff, L., Gridley, G., Chow, W. H., Linet, M., Mellemkjaer, L., Olsen, J. H., Keehn, S., & Borch-Johnsen, K. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.18.1360 · Cited by 627 · see citing works

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

Bergman, R. N., & Ader, M. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00323-4 · Cited by 622 · see citing works

Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia

Chow, W., Blot, W. J., Vaughan, T. L., Risch, H. A., Gammon, M. D., Stanford, J. L., Dubrow, R., Schoenberg, J. B., Mayne, S. T., Farrow, D. C., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.2.150 · Cited by 622 · see citing works

Weight Loss in Breast Cancer Patient Management

Chlebowski, R. T., Aiello, E. J., & McTiernan, A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.4.1128 · Cited by 618 · see citing works

Energy balance and cancer: the role of insulin and insulin-like growth factor-I

Kaaks, R., & Lukanova, A. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200070 · Cited by 615 · see citing works

Screening and Interventions for Obesity in Adults: Summary of the Evidence for the U.S. Preventive Services Task Force

McTigue, K. M., Harris, R., Hemphill, B., Lux, L. J., Sutton, S. F., Bunton, A. J., & Lohr, K. N. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-11-200312020-00013 · Cited by 601 · see citing works

Exercise and Insulin Sensitivity: A Review

Borghouts, L. B., & KEIZER, H. A. (2000) · International Journal of Sports Medicine · doi:10.1055/s-2000-8847 · Cited by 598 · see citing works

A prospective study of obesity and cancer risk (Sweden)

Wolk, A., Gridley, G., Svensson, M., Nyrén, O., McLaughlin, J. K., Fraumeni, J. F., & Adami, H.-O. (2001) · Cancer Causes & Control · doi:10.1023/a:1008995217664 · Cited by 581 · see citing works

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575 · see citing works

The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk

Key, T., & Pike, M. (1988) · British Journal of Cancer · doi:10.1038/bjc.1988.44 · Cited by 554 · see citing works

Invited Review: Effects of acute exercise and exercise training on insulin resistance

Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535 · see citing works

Resistin and obesity-associated insulin resistance

Steppan, C. M., & Lazar, M. A. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00522-7 · Cited by 525 · see citing works

State‐Level Estimates of Annual Medical Expenditures Attributable to Obesity*

Finkelstein, E. A., Fiebelkorn, I. C., & Wang, G. (2004) · Obesity Research · doi:10.1038/oby.2004.4 · Cited by 520 · see citing works

Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.

Vaughan, T. L., Davis, S., Kristal, A. R., & Thomas, D. B. (1995) · PubMed · Cited by 516 · see citing works

Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*

EHRMAN, D. A., Barnes, R. B., & Rosenfield, R. L. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-322 · Cited by 502 · see citing works

Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer

Schoen, R. E., Tangen, C. M., Kuller, L. H., Burke, G. L., Cushman, M., Tracy, R. P., Dobs, A. S., & Savage, P. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.13.1147 · Cited by 500 · see citing works

Diet, Body Size, and Breast Cancer

Hunter, D. J., & Willett, W. C. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036096 · Cited by 493 · see citing works

Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

McKeown‐Eyssen, G. (1994) · PubMed · Cited by 474 · see citing works

A global response to a global problem: the epidemic of overnutrition.

Chopra, M., Galbraith, S., & Darnton‐Hill, I. (2002) · Europe PMC (PubMed Central) · Cited by 472 · see citing works

Age Changes in Body Composition Revealed by Computed Tomography

Borkan, G. A., Hults, D. E., Gerzof, S. G., Robbins, A. H., & Silbert, C. K. (1983) · Journal of Gerontology · doi:10.1093/geronj/38.6.673 · Cited by 460 · see citing works

Obesity and cancer risk: a danish record-linkage study

Møller, H., Mellemgaard, A., Lindvig, K., & Olsen, J. H. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)90254-2 · Cited by 449 · see citing works

Obesity and Estrogen as Risk Factors for Gastroesophageal Reflux Symptoms

Nilsson, M., Johnsen, R., Ye, W., Hveem, K., & Lagergren, J. (2003) · JAMA · doi:10.1001/jama.290.1.66 · Cited by 446 · see citing works

Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

Holmes, M. D., Pollak, M., Willett, W. C., & Hankinson, S. E. (2002) · PubMed · Cited by 437 · see citing works

Abnormal Glucose Metabolism and Pancreatic Cancer Mortality

Gapstur, S. M. (2000) · JAMA · doi:10.1001/jama.283.19.2552 · Cited by 420 · see citing works

Nutrition and Survival After the Diagnosis of Breast Cancer: A Review of the Evidence

Rock, C. L., & Demark‐Wahnefried, W. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.03.008 · Cited by 408 · see citing works

Body Size and Prostate Cancer: A 20-Year Follow-up Study Among 135006 Swedish Construction Workers

Andersson, S.-O., Wolk, A., Bergström, R., Adami, H., Engholm, G., Englund, A., & Nyrén, O. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.5.385 · Cited by 406 · see citing works

Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study

Stattin, P. E. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.23.1910 · Cited by 406 · see citing works

Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion

Ehrmann, D. A. (1995) · Endocrine Reviews · doi:10.1210/er.16.3.322 · Cited by 403 · see citing works

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

Giovannucci, E. L., Pollak, M., Platz, E. A., Willett, W. C., Stampfer, M. J., Majeed, N., Colditz, G. A., Speizer, F. E., & Hankinson, S. E. (2000) · PubMed · Cited by 401 · see citing works

Role of insulin-like growth factor binding proteins in controlling IGF actions

Clemmons, D. R. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00024-0 · Cited by 396 · see citing works

Central obesity and breast cancer risk: a systematic review

Harvie, M., Hooper, L., & Howell, A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00108.x · Cited by 392 · see citing works

Pathologic Variables and Recurrence Rates As Related to Obesity and Race in Men With Prostate Cancer Undergoing Radical Prostatectomy

Amling, C. L., Riffenburgh, R. H., Sun, L. L., Moul, J. W., Lance, R. S., Kusuda, L., Sexton, W. J., Soderdahl, D. W., Donahue, T. F., Foley, J. P., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.03.132 · Cited by 384 · see citing works

Impact of Obesity on Biochemical Control After Radical Prostatectomy for Clinically Localized Prostate Cancer: A Report by the Shared Equal Access Regional Cancer Hospital Database Study Group

Freedland, S. J., Aronson, W. J., Kane, C. J., Presti, J. C., Amling, C. L., Elashoff, D. A., & Terris, M. K. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.04.181 · Cited by 382 · see citing works

The Relation of Gastroesophageal Reflux Disease and Its Treatment to Adenocarcinomas of the Esophagus and Gastric Cardia

Chow, W.-H. (1995) · JAMA · doi:10.1001/jama.1995.03530060048032 · Cited by 365 · see citing works

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

Tannenbaum, G. S., Guyda, H. J., & Posner, B. I. (1983) · Science · doi:10.1126/science.6338593 · Cited by 362 · see citing works

Nutrition, hormones, and breast cancer: Is insulin the missing link?

Kaaks, R. (1996) · Cancer Causes & Control · doi:10.1007/bf00051703 · Cited by 361 · see citing works

Insulin resistance and breast‐cancer risk

Bruning, P. F., Bonfrèr, J. M. G., van Noord, P. A. H., Hart, A. A. M., Jong‐Bakker, M. D., & Nooijen, W. J. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520402 · Cited by 360 · see citing works

Estrogen Replacement Therapy and Risk of Fatal Colon Cancer in a Prospective Cohort of Postmenopausal Women

Calle, E. E., Miracle-McMahill, H. L., Thun, M. J., & Heath, C. W. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.7.517 · Cited by 360 · see citing works

Fasting glucose is a risk factor for breast cancer: a prospective study.

Muti, P. C., Quattrin, T., Grant, B. J. B., Krogh, V., Micheli, A., Schünemann, H. J., Ram, M., Freudenheim, J. L., Sieri, S., Trevisan, M., et al. (2002) · PubMed · Cited by 358 · see citing works

A meta-analysis of obesity and the risk of pancreatic cancer

de González, A. B., Sweetland, S., & Spencer, E. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601140 · Cited by 349 · see citing works

Association of Obesity and Cancer Risk in Canada

Pan, S. Y. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh041 · Cited by 342 · see citing works

Recent Advances in Our Understanding of Insulin Action and Insulin Resistance

Roith, D. L., & Zick, Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.588 · Cited by 337 · see citing works

American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity

Byers, T., Nestle, M., McTiernan, A., Doyle, C., Currie-Williams, A., Gansler, T., & Thun, M. (2002) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.2.92 · Cited by 336 · see citing works

INCREASED INCIDENCE OF CARCINOMA OF THE BREAST ASSOCIATED WITH ABDOMINAL ADIPOSITY IN POSTMENOPAUSAL WOMEN

FOLSOM, A. R., Kaye, S. A., Prineas, R. J., Potter, J. D., Gapstur, S. M., & Wallace, R. B. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115570 · Cited by 331 · see citing works

Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States.

Rodríguez, C., Patel, A. V., Calle, E. E., Jacobs, E. J., Chao, A., & Thun, M. J. (2001) · PubMed · Cited by 326 · see citing works

Obesity and colon cancer: Does leptin provide a link?

Stattin, P. E., Lukanova, A., Biessy, C., Söderberg, S., Palmqvist, R., Kaaks, R., Olsson, T., & Jellum, E. (2003) · International Journal of Cancer · doi:10.1002/ijc.11668 · Cited by 319 · see citing works

Obesity and cancer risk among white and black United States veterans

Samanic, C. M., Gridley, G., Chow, W., Lubin, J. H., Hoover, R. N., & Fraumeni, J. F. (2004) · Cancer Causes & Control · doi:10.1023/b:caco.0000016573.79453.ba · Cited by 318 · see citing works

Obesity and renal cell cancer – a quantitative review

Bergström, A., Hsieh, C.-C., Lindblad, P., Lu, C., Cook, N. R., & Wolk, A. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2040 · Cited by 316 · see citing works

Hepatic steatosis in obese patients: clinical aspects and prognostic significance

Festi, D., Colecchia, A., Sacco, T., Bondi, M., Roda, E., & Marchesini, G. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00126.x · Cited by 312 · see citing works

Chapter 2: The Role of Steroid Hormones in Prostate Carcinogenesis

Bosland, M. C. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024244 · Cited by 307 · see citing works

Insulin and related factors in premenopausal breast cancer risk

Giudice, M. E. D., Fantus, I. G., Ezzat, S., McKeown‐Eyssen, G., Page, D. L., & Goodwin, P. J. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1005831013718 · Cited by 304 · see citing works

Screening for Cervical and Breast Cancer: Is Obesity an Unrecognized Barrier to Preventive Care?

Wee, C. C., McCarthy, E. P., Davis, R. B., & Phillips, R. S. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-9-200005020-00003 · Cited by 299 · see citing works

A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States)

Wu, A. H., Wan, P. C., & Bernstein, L. (2001) · Cancer Causes & Control · doi:10.1023/a:1011290704728 · Cited by 297 · see citing works

Dietary fat, fatty acid composition in plasma and the metabolic syndrome

Vessby, B. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200302000-00004 · Cited by 291 · see citing works

Epidemiologic Aspects of Gallbladder Cancer: A Case-Control Study of the SEARCH Program of the International Agency for Research on Cancer

Zatoński, W. A., Przewozniak, K., Lowenfels, A. B., Boyle, P., Maisonneuve, P., Bueno-de-Mesquita, H. B., Moerman, C. J., Ghadirian, P., Simard, A., Jain, M., et al. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.15.1132 · Cited by 287 · see citing works

Physical activity, obesity, and risk of colorectal adenoma in women (United States)

Giovannucci, E. L., Colditz, G. A., Stampfer, M. J., & Willett, W. C. (1996) · Cancer Causes & Control · doi:10.1007/bf00051301 · Cited by 285 · see citing works

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

Robinson, S., Kiddy, D. S., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., Johnston, D. G., & Franks, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02376.x · Cited by 282 · see citing works

Height, body weight, and risk of prostate cancer.

Giovannucci, E. L., Rimm, E. B., Stampfer, M. J., Colditz, G. A., & Willett, W. C. (1997) · PubMed · Cited by 282 · see citing works

Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden

Palmqvist, R., Hallmans, G., Rinaldi, S., Biessy, C., Stenling, R., Riboli, E., & Kaaks, R. (2002) · Gut · doi:10.1136/gut.50.5.642 · Cited by 280 · see citing works

Molecular mechanisms of insulin resistance and the role of the adipocyte

Hotamisligil, G. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801497 · Cited by 270 · see citing works

Reflux, Barrett's oesophagus and adenocarcinoma: burning questions

Wild, C. P., & Hardie, L. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1166 · Cited by 265 · see citing works

Dietary and Nutritional Factors and Pancreatic Cancer: a Case-Control Study Based on Direct Interviews

Silverman, D. T., Swanson, C. A., Gridley, G., Wacholder, S., Brown, L. M., Hayes, R. B., Fraumeni, J. F., Hoover, R. N., Pottern, L. M., Greenberg, R. S., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.22.1710 · Cited by 262 · see citing works

Breast Cancer and Obesity: An Update

Stephenson, G. D., & Rose, D. P. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4501_1 · Cited by 258 · see citing works

A Population-Based Case-Control Study of Renal Cell Carcinoma

McLaughlin, J. K., Mandel, J. S., Blot, W. J., Schuman, L. M., Mehl, E. S., & Fraumeni, J. F. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.2.275 · Cited by 249 · see citing works

Re: Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status

Thomas, H. V., Key, T. J., Allen, D. S., Moore, J. W., Dowsett, M., Fentiman, I. S., & Wang, D. Y. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.5.396 · Cited by 246 · see citing works

Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Obesity in Men and Women

Tchernof, A., & Despres, J. (2000) · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · doi:10.1055/s-2007-978681 · Cited by 244 · see citing works

Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women

Lukanova, A., Lundin, E., Micheli, A., Arslan, A. A., Ferrari, P., Rinaldi, S., Krogh, V., Lenner, P., Shore, R. E., Biessy, C., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11529 · Cited by 239 · see citing works

Obesity

Björntorp, P. A. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04503-0 · Cited by 234 · see citing works

Progress in obesity research: 7

Angel, A. (1996) · Medical Entomology and Zoology · Cited by 232 · see citing works

Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women

Petrelli, J. M., Calle, E. E., Rodríguez, C., & Thun, M. J. (2002) · Cancer Causes & Control · doi:10.1023/a:1015288615472 · Cited by 228 · see citing works

No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study

Lagergren, J., Bergström, R., & Nyrén, O. (2000) · Gut · doi:10.1136/gut.47.1.26 · Cited by 224 · see citing works

The role of diabetes mellitus in the aetiology of renal cell cancer

Lindblad, P., Chow, W. H., Chan, J., Bergström, A., Wolk, A., Gridley, G., McLaughlin, J. K., Nyrén, O., & Adami, H. O. (1999) · Diabetologia · doi:10.1007/s001250051122 · Cited by 220 · see citing works

Height, body mass index, and prostate cancer: a follow-up of 950 000 Norwegian men

Engeland, A., Tretli, S., & Bjørge, T. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601206 · Cited by 219 · see citing works

Weight Gain, Body Mass Index, Hormone Replacement Therapy, and Postmenopausal Breast Cancer in a Large Prospective Study

Feigelson, H. S., Jonas, C. R., Teras, L. R., Thun, M. J., & Calle, E. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-03-0301 · Cited by 218 · see citing works

Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status

Potischman, N. A., Swanson, C. A., Siiteri, P. K., & Hoover, R. N. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.11.756 · Cited by 218 · see citing works

Pathophysiology of sex hormone binding globulin (SHBG): Relation to insulin

PUGEAT, M. M., Crave, J. C., Elmidani, M., Nicolas, M. H., Garoscio-Cholet, M., Lejeune, H., Déchaud, H., & TOURNIAIRE, J. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90310-2 · Cited by 214 · see citing works

Body Size and Risk of Breast Cancer

Trentham‐Dietz, A., Newcomb, P. A., Storer, B. E., Longnecker, M. P., Baron, J. A., Greenberg, E. R., & Willett, W. C. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009057 · Cited by 213 · see citing works

Hormones and prostate cancer: Current perspectives and future directions

Hsing, A. W., Reichardt, J. K. V., & Stanczyk, F. Z. (2002) · The Prostate · doi:10.1002/pros.10108 · Cited by 208 · see citing works

Association between Medications That Relax the Lower Esophageal Sphincter and Risk for Esophageal Adenocarcinoma

Lagergren, J., Bergström, R., Adami, H., & Nyrén, O. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-3-200008010-00007 · Cited by 202 · see citing works

Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden

Kaaks, R., Lundin, E., Manjer, J., Rinaldi, S., Biessy, C., Söderberg, S., Lenner, P., Janzon, L., Ríboli, E., Berglund, G. L., et al. (2002) · Cancer Causes & Control · doi:10.1023/a:1015270324325 · Cited by 198 · see citing works

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

Ish‐Shalom, D., Christoffersen, C. T., Vorwerk, P., Sacerdoti‐Sierra, N., Shymko, R. M., Naor, D., & MEYTS, P. D. (1997) · Diabetologia · doi:10.1007/s001250051393 · Cited by 193 · see citing works

Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study

Zeleniuch‐Jacquotte, A., Shore, R. E., Koenig, K. L., Akhmedkhanov, A., Afanasyeva, Y., Kato, I., Kim, M. Y., Rinaldi, S., Kaaks, R., & Toniolo, P. G. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601517 · Cited by 186 · see citing works

Obesity and endocrine disease

Kokkoris, P., & Pi-Sunyer, X. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00078-1 · Cited by 184 · see citing works

Case-Control Study of Non-Hodgkin's Lymphoma among Women and Heterosexual Men in the San Francisco Bay Area, California

Holly, E. A., Lele, C., Bracci, P. M., & McGrath, M. S. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010017 · Cited by 182 · see citing works

Role of Hormones in the Growth and Regression of Human Breast Cancer Cells (MCF-7) Transplanted Into Athymic Nude Mice 2

Shafie, S. M., & Grantham, F. H. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.1.51 · Cited by 181 · see citing works

Energy balance and cancer: the role of sex hormones

Key, T. J., Allen, N. E., Verkasalo, P. K., & Banks, E. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200068 · Cited by 180 · see citing works

Prediagnostic levels of C‐peptide, IGF‐I, IGFBP ‐1, ‐2 and ‐3 and risk of endometrial cancer

Lukanova, A., Zeleniuch‐Jacquotte, A., Lundin, E., Micheli, A., Arslan, A. A., Rinaldi, S., Muti, P. C., Lenner, P., Koenig, K. L., Biessy, C., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11544 · Cited by 178 · see citing works

A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (2000) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(00)90013-3 · Cited by 175 · see citing works

Handbook of obesity : etiology and pathophysiology

Bray, G. A., & Bouchard, C. (2004) · M. Dekker eBooks · Cited by 174 · see citing works

Mild hypogonadotropic hypogonadism in obese men

Strain, G. W., Zumoff, B., Kream, J., Strain, J. J., Deucher, R., Rosenfeld, R. S., Levin, J., & Fukushima, D. K. (1982) · Metabolism · doi:10.1016/0026-0495(82)90175-5 · Cited by 174 · see citing works

Chapter 8: Estrogen Receptor-Mediated Processes in Normal and Cancer Cells

Dickson, R. B., & Stancel, G. M. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024237 · Cited by 168 · see citing works

A simple estimate of mortality attributable to excess weight in the European Union

Banegas, J. R., López‐García, E., Gutiérrez-Fisac, J. L., Guallar‐Castillón, P., & Rodríguez‐Artalejo, F. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601538 · Cited by 167 · see citing works

Reducing the risk of cancer with healthy food choices and physical activity

Byers, T. (2002) · CA A Cancer Journal for Clinicians · Cited by 161 · see citing works

Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study

Zeleniuch‐Jacquotte, A., Akhmedkhanov, A., Kato, I., Koenig, K. L., Shore, R. E., Kim, M. Y., Levitz, M., Mittal, K., Raju, U., Banerjee, S. N., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1704 · Cited by 158 · see citing works

Height, Body Mass Index, and Ovarian Cancer: A Follow-Up of 1.1 Million Norwegian Women

Engeland, A., Tretli, S., & Bjørge, T. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg010 · Cited by 155 · see citing works

Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction.

Heuson, J.-C., & Legros, N. (1972) · PubMed · Cited by 153 · see citing works

Body weight: estimation of risk for breast and endometrial cancers

Ballard-Barbash, R. R., & Swanson, C. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.437 · Cited by 147 · see citing works

Diet composition and the metabolic syndrome: what is the optimal fat intake?

Grundy, S. M., Abate, N. I., & Chandalia, M. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00988-3 · Cited by 146 · see citing works

Circulating levels of insulin‐like growth factor‐I and risk of ovarian cancer

Lukanova, A., Lundin, E., Toniolo, P. G., Micheli, A., Akhmedkhanov, A., Rinaldi, S., Muti, P. C., Lenner, P., Biessy, C., Krogh, V., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10613 · Cited by 140 · see citing works

Risk factors for renal‐cell cancer in Shanghai, China

McLaughlin, J. K., Gao, Y., Gao, R., Zheng, W., Ji, B., Blot, W. J., & Fraumeni, J. F. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520411 · Cited by 139 · see citing works

Dietary factors and risk of pancreatic cancer: Results of a Canadian population‐based case‐control study

Howe, G. R., Jain, M., & Miller, A. B. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910450405 · Cited by 139 · see citing works

Relationship between Quetelet's index and cancer of breast and female genital tract in 47,000 women followed for 25 years

Törnberg, S., & Carstensen, J. M. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.65 · Cited by 136 · see citing works

Depressed Plasma Testosterone and Fractional Binding of Testosterone in Obese Males*

Amatruda, J. M., Harman, S. M., Pourmotabbed, G., & LOCKWOODF, D. H. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-2-268 · Cited by 132 · see citing works

Insulin and IGF-I Receptors Signaling in Protection from Apoptosis

di Prisco, M., Romano, G., Peruzzi, F., Valentinis, B., & Baserga, R. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978703 · Cited by 131 · see citing works

Western nutrition and the insulin resistance syndrome: A link to breast cancer

Stoll, B. A. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600700 · Cited by 131 · see citing works

Nutritional factors and pancreatic cancer in the francophone community in montréal, Canada

Ghadirian, P., Simard, A., Baillargeon, J., Maisonneuve, P., & Boyle, P. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910470102 · Cited by 130 · see citing works

Obesity as a potential risk factor for adenocarcinomas and squamous cell carcinomas of the uterine cervix

Lacey, J. V., Swanson, C. A., Brinton, L. A., Altekruse, S. F., Barnes, W. A., Gravitt, P. E., Greenberg, M., Hadjimichael, O. C., McGowan, L., Mortel, R., et al. (2003) · Cancer · doi:10.1002/cncr.11567 · Cited by 128 · see citing works

Body mass index, height, and the risk of ovarian cancer mortality in a prospective cohort of postmenopausal women.

Rodríguez, C., Calle, E. E., Fakhrabadi‐Shokoohi, D., Jacobs, E. J., & Thun, M. J. (2002) · PubMed · Cited by 128 · see citing works

Quantitative analysis of estrogen receptor-? mRNA and its variants in human breast cancers

Iwao, K., Miyoshi, Y., Egawa, C., Ikeda, N., & Noguchi, S. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001201)88:5 · Cited by 124 · see citing works

Obesity, Weight Gain, and Ovarian Cancer

Fairfield, K. M., Willett, W. C., ROSNER, B. A., Manson, J. E., Speizer, F. E., & Hankinson, S. E. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02053-7 · Cited by 123 · see citing works

Race, Nutritional Status, and Survival From Breast Cancer

Coates, R. J., Clark, W. S., Eley, J. W., Greenberg, R. S., Huguly, C. M., & Brown, R. L. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.21.1684 · Cited by 117 · see citing works

Anthropometric Characteristics, Physical Activity, and Risk of Non-Hodgkin's Lymphoma Subtypes and B-Cell Chronic Lymphocytic Leukemia: A Prospective Study

Cerhan, J. R. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf082 · Cited by 110 · see citing works

The effect of pre-morbid height and weight on the survival of breast cancer patients

Tretli, S., Haldorsen, T., & Ottestad, L. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.282 · Cited by 108 · see citing works

Circulating levels of insulin‐like growth factor I, its binding proteins ‐1,‐2, ‐3, C‐peptide and risk of postmenopausal breast cancer

Keinan‐Boker, L., Bueno-de-Mesquita, H. B., Kaaks, R., van Gils, C. H., van Noord, P. A. H., Rinaldi, S., Ríboli, E., Seidell, J. C., Grobbee, D. E., & Peeters, P. H. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.11193 · Cited by 107 · see citing works

Occurrence, trends and environmental etiology of pancreatic cancer

Weiderpass, E., Partanen, T. J., Kaaks, R., Vainio, H., Porta, M. S., Kauppinen, T. P., Ojajärvi, A., Boffetta, P., & Malats, N. (1998) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.295 · Cited by 107 · see citing works

Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review

Kaaks, R., Lukanova, A., & Sommersberg, B. (2000) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500421 · Cited by 105 · see citing works

Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women

Allen, N. E., Appleby, P. N., Kaaks, R., Rinaldi, S., Davey, G. K., & Key, T. J. (2003) · Cancer Causes & Control · doi:10.1023/a:1022518321634 · Cited by 104 · see citing works

Nutritional factors and pancreatic cancer: A case‐control study from South‐West Poland

Zatoński, W. A., Przewozniak, K., Howe, G. R., Maisonneuve, P., Walker, A. M., & Boyle, P. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910480314 · Cited by 104 · see citing works

Early body size and subsequent weight again as predictors of breast cancer incidence (Iowa, United States)

Barnes-Josiah, D. L., Potter, J. D., Sellers, T. A., & Himes, J. H. (1995) · Cancer Causes & Control · doi:10.1007/bf00052771 · Cited by 103 · see citing works

Physical activity, anthropometric factors and risk of pancreatic cancer: Results from the Canadian enhanced cancer surveillance system

Hanley, A. J., Johnson, K. C., Villeneuve, P. J., & Mao, Y. (2001) · International Journal of Cancer · doi:10.1002/ijc.1446 · Cited by 103 · see citing works

Nutrition and renal cell cancer

Wolk, A., Lindblad, P., & Adami, H. (1996) · Cancer Causes & Control · doi:10.1007/bf00115634 · Cited by 103 · see citing works

Height, Weight, Weight Change, and Ovarian Cancer Risk in the Netherlands Cohort Study on Diet and Cancer

Schouten, L. J. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf224 · Cited by 98 · see citing works

Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United States

Galanis, D. J., Kolonel, L. N., Lee, J., & Marchand, L. L. (1998) · Cancer Causes & Control · doi:10.1023/a:1008842613331 · Cited by 83 · see citing works

Body Mass Index at Age 18 Years and during Adult Life and Ovarian Cancer Risk

Lubin, F. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf184 · Cited by 82 · see citing works

Obesity and risk of renal cell cancer.

Chow, W., McLaughlin, J. K., Mandel, J. S., Wacholder, S., Niwa, S., & Fraumeni, J. F. (1996) · PubMed · Cited by 81 · see citing works

Serum concentrations of IGF‐I, IGFBP‐3 and c‐peptide and risk of hyperplasia and cancer of the breast in postmenopausal women

Schairer, C., Hill, D. A., Sturgeon, S. R., Fears, T. R., Pollak, M., Mies, C., Ziegler, R. G., Hoover, R. N., & Sherman, M. E. (2003) · International Journal of Cancer · doi:10.1002/ijc.11624 · Cited by 80 · see citing works

Nutrition and endometrial cancer

Hill, H. A., & Austin, H. D. (1996) · Cancer Causes & Control · doi:10.1007/bf00115635 · Cited by 80 · see citing works

Risk factors for renal‐cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors

Mellemgaard, A., Engholm, G., McLaughlin, J. K., & Olsen, J. H. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560113 · Cited by 77 · see citing works

Population-based, case-control study of blood C-peptide level and breast cancer risk.

Yang, G., Lu, G. G., Jin, F., Dai, Q., Best, R., Shu, X., Chen, J., Pan, X. Y., Shrubsole, M. J., & Zheng, W. (2001) · PubMed · Cited by 77 · see citing works

Body mass index and the risk of cancers of the gastric cardia and distal stomach in Shanghai, China.

Ji, B., Chow, W. H., Yang, G., McLaughlin, J. K., Gao, R. N., Zheng, W., Shu, X. O., Jin, F., Fraumeni, J. F., & Gao, Y. (1997) · PubMed · Cited by 76 · see citing works

Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis

Heegaard, S., Sommer, H. M., Broholm, H., & Brœndstrup, O. (1995) · Cancer · doi:10.1002/1097-0142(19951115)76:10 · Cited by 75 · see citing works

Pre-morbid body-mass-index in breast cancer: Reversed effect on survival in hormone receptor negative patients

Maehle, B. O., & Tretli, S. (1996) · Breast Cancer Research and Treatment · doi:10.1007/bf01807157 · Cited by 75 · see citing works

Risk of ovarian cancer in the United States in relation to anthropometric measures: does the association depend on menopausal status?

Kuper, H. E., Cramer, D. W., & Titus-Ernstoff, L. T. (2002) · Cancer Causes & Control · doi:10.1023/a:1015751105039 · Cited by 73 · see citing works

Leanness and Lung Cancer Risk: Fact or Artifact?

Henley, S. J., Flanders, W. D., Manatunga, A. K., & Thun, M. J. (2002) · Epidemiology · doi:10.1097/00001648-200205000-00006 · Cited by 73 · see citing works

Physical activity, body weight, and pancreatic cancer mortality

Lee, I.-M. M., Sesso, H. D., Oguma, Y., & Paffenbarger, R. S. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600782 · Cited by 73 · see citing works

Hormones and Hormone Antagonists: Mechanisms of Action in Carcinogenesis of Endometrial and Breast Cancer

Flötotto, T., Djahansouzi, S., Gläser, M., Hanstein, B., Niederacher, D., Brumm, C., & Beckmann, M. W. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-16936 · Cited by 70 · see citing works

Are energy and energy‐providing nutrients related to exocrine carcinoma of the pancreas?

Bueno-de-Mesquita, H. B., Moerman, C. J., Runia, S., & Maisonneuve, P. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910460319 · Cited by 70 · see citing works

Fat and the liver--a molecular overview.

Harrison, S. A., & Diehl, A. M. (2002) · PubMed · Cited by 70 · see citing works

Recovery of Growth Hormone Release from Suppression by Exogenous Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive Action of Free Rather Than Bound IGF-I1

Chapman, I. M., Hartman, M. L., Pieper, K. S., Skiles, E. H., Pezzoli, S. S., Hintz, R. L., & Thorner, M. O. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.5040 · Cited by 69 · see citing works

Progress in obesity research

Westerterp, K. R. (2003) · Cited by 69 · see citing works

Genetics of insulin resistance

Pedersen, O. B. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212085 · Cited by 68 · see citing works

Storing up problems: the medical case for a slimmer nation

Prentice, A. (2004) · Clinical Medicine · doi:10.7861/clinmedicine.4-2-99 · Cited by 66 · see citing works

Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women.

Hirose, K., Toyama, T., Iwata, H., Takezaki, T., Hamajima, N., & Tajima, K. (2003) · PubMed · Cited by 60 · see citing works

Anthropometric Measures and Body Composition

Willett, W. C. (1998) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195122978.003.10 · Cited by 54 · see citing works

High-insulinogenic nutrition—an etiologic factor for obesity and the metabolic syndrome?

Kopp, W. (2003) · Metabolism · doi:10.1016/s0026-0495(02)05294-0 · Cited by 51 · see citing works

Variations on the Picturesque: Authority, Play, and Practice

Harrison, G., & Heydt-Stevenson, J. (2002) · European Romantic Review · doi:10.1080/10509580212768 · Cited by 50 · see citing works

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., & Zwahlen, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60269-x · Cited by 5,219 · see citing works

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

Prospective Studies Collaboration (2009) · The Lancet · doi:10.1016/s0140-6736(09)60318-4 · Cited by 4,807 · see citing works

Body Fatness and Cancer — Viewpoint of the IARC Working Group

Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K. (2016) · New England Journal of Medicine · doi:10.1056/nejmsr1606602 · Cited by 3,596 · see citing works

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,196 · see citing works

Influence of tumour micro-environment heterogeneity on therapeutic response

Junttila, M. R., & de Sauvage, F. J. (2013) · Nature · doi:10.1038/nature12626 · Cited by 2,694 · see citing works

Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

Keum, N., & Giovannucci, E. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0189-8 · Cited by 2,690 · see citing works

Combination therapy in combating cancer

Mokhtari, R. B., Homayouni, T. S., Baluch, N., Morgatskaya, E., Kumar, S., Das, B., & Yeger, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16723 · Cited by 2,543 · see citing works

Diabetes and Cancer

Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366 · see citing works

Obesity and Kidney Disease: Hidden Consequences of the Epidemic

Kovesdy, C. P., Furth, S. L., & Zoccali, C. (2017) · American Journal of Nephrology · doi:10.1159/000458467 · Cited by 2,239 · see citing works

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works

Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old

Adams, K. F., Schatzkin, A. G., Harris, T. B., Kipnis, V., Mouw, T., Ballard-Barbash, R. R., Hollenbeck, A. R., & Leitzmann, M. F. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055643 · Cited by 2,115 · see citing works

Insulin and insulin-like growth factor signalling in neoplasia

Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059 · see citing works

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2009.12.052 · Cited by 1,764 · see citing works

The microbiome and cancer

Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689 · see citing works

Epidemiology of ovarian cancer: a review

Reid Brett, M., Reid Brett, M., Permuth, J. B., Sellers Thomas, A., Permuth, J. B., & Sellers Thomas, A. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2016.0084 · Cited by 1,536 · see citing works

Insulin and insulin resistance:

Sowers, J. R., & Frohlich, E. D. (2004) · Medical Clinics of North America · doi:10.1016/s0025-7125(03)00128-7 · Cited by 1,521 · see citing works

Sedentary Behaviors and Subsequent Health Outcomes in Adults

Thorp, A. A., Owen, N., Neuhaus, M., & Dunstan, D. W. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.05.004 · Cited by 1,455 · see citing works

Targeting cancer metabolism: a therapeutic window opens

Heiden, M. G. V. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3504 · Cited by 1,409 · see citing works

Epidemiology and risk factors for kidney cancer

Chow, W.-H., Dong, L. M., & Devesa, S. S. (2010) · Nature Reviews Urology · doi:10.1038/nrurol.2010.46 · Cited by 1,395 · see citing works

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Ridker, P. M., MacFadyen, J. G., Thuren, T., Everett, B. M., Libby, P., Glynn, R. J., Ridker, P., Lorenzatti, A., Krum, H., Varigos, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32247-x · Cited by 1,344 · see citing works

Lipid metabolism in cancer

Santos, C. R., & Schulze, A. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08644.x · Cited by 1,344 · see citing works

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection

Starley, B. Q., Calcagno, C. J., & Harrison, S. A. (2010) · Hepatology · doi:10.1002/hep.23594 · Cited by 1,340 · see citing works

American Cancer Society guidelines on nutrition and physical activity for cancer prevention

Kushi, L. H., Doyle, C., McCullough, M. L., Rock, C. L., Demark‐Wahnefried, W., Bandera, E. V., Gapstur, S. M., Patel, A. V., Andrews, K. S., & Gansler, T. S. (2012) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20140 · Cited by 1,331 · see citing works

The Metabolic Syndrome

Grundy, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5839-6_1 · Cited by 1,225 · see citing works

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

Manna, P., & Jain, S. K. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0095 · Cited by 1,167 · see citing works

Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion

Dirat, B., Bochet, L., Dabek, M., Daviaud, D., Dauvillier, S., Majed, B., Wang, Y. Y., Meulle, A., Salles, B., Le Gonidec, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3323 · Cited by 1,134 · see citing works

Leptin and Obesity: Role and clinical implication.

Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.585887 · Cited by 1,121 · see citing works

Diabetes and Cancer: A Consensus Report

Giovannucci, E. L., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20078 · Cited by 1,065 · see citing works

Insulin and insulin resistance.

Wilcox, G. (2005) · PubMed Central · Cited by 1,040 · see citing works

Epidemiology of epithelial ovarian cancer

Webb, P. M., & Jordan, S. J. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.08.006 · Cited by 998 · see citing works

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S.-W., & Cravatt, B. F. (2010) · Cell · doi:10.1016/j.cell.2009.11.027 · Cited by 1,002 · see citing works

Global burden of cancer attributable to high body-mass index in 2012: a population-based study

Arnold, M., Pandeya, N., Byrnes, G. B., Renehan, A. G., Stevens, G. A., Ezzati, M., Ferlay, J., Miranda, J. J., Romieu, I., Dikshit, R. P., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)71123-4 · Cited by 994 · see citing works

Socially Assistive Robotics

Feil-Seifer, D., & Matarić, M. J. (2005) · International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2005.1501143 · Cited by 995 · see citing works

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

McAllister, S. S., & Weinberg, R. A. (2014) · Nature Cell Biology · doi:10.1038/ncb3015 · Cited by 966 · see citing works

Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis

Protani, M. M., Coory, M. D., & Martin, J. H. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0990-0 · Cited by 961 · see citing works

Obesity as a Major Risk Factor for Cancer

Pergola, G. D., & Silvestris, F. (2013) · Journal of Obesity · doi:10.1155/2013/291546 · Cited by 964 · see citing works

The fractions of cancer attributable to modifiable factors: A global review

Whiteman, D. C., & Wilson, L. F. (2016) · Cancer Epidemiology · doi:10.1016/j.canep.2016.06.013 · Cited by 889 · see citing works

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.19.6410 · Cited by 880 · see citing works

Abdominal Obesity and the Risk of All-Cause, Cardiovascular, and Cancer Mortality: Sixteen Years of Follow-Up in US Women

Zhang, C., Rexrode, K. M., van Dam, R. M., Li, T. Y., & Hu, F. B. (2008) · Circulation · doi:10.1161/circulationaha.107.739714 · Cited by 856 · see citing works

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Beyaz, S., Mana, M., Roper, J., Kedrin, D., Saadatpour, A., Hong, S., Bauer-Rowe, K. E., Xifaras, M. E., Akkad, A., Arias, E., et al. (2016) · Nature · doi:10.1038/nature17173 · Cited by 840 · see citing works

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

Carta, G., Murru, E., Banni, S., & Manca, C. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00902 · Cited by 813 · see citing works

Mechanisms and consequences of intestinal dysbiosis

Weiss, G. A., & Hennet, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2509-x · Cited by 775 · see citing works

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

Taniguchi, K., & Karin, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.001 · Cited by 713 · see citing works

Obesity and cancer: the role of dysfunctional adipose tissue

van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0372 · Cited by 715 · see citing works

Nutrients, foods, and colorectal cancer prevention

Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.003 · Cited by 678 · see citing works

Adiposity and cancer risk: new mechanistic insights from epidemiology

Renehan, A. G., Zwahlen, M., & Egger, M. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3967 · Cited by 654 · see citing works

Endometrial Cancer

Lu, K. H., & Broaddus, R. R. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1514010 · Cited by 669 · see citing works

Adult Weight Change and Risk of Postmenopausal Breast Cancer

Eliassen, A. H., Colditz, G. A., Rosner, B., Willett, W. C., & Hankinson, S. E. (2006) · JAMA · doi:10.1001/jama.296.2.193 · Cited by 654 · see citing works

Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment

Onstad, M. A., Schmandt, R. E., & Lu, K. H. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.69.4638 · Cited by 649 · see citing works

The Role of Adiponectin in Cancer: A Review of Current Evidence

Dalamaga, Μ., Diakopoulos, K. N., & Mantzoros, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1015 · Cited by 639 · see citing works

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Michelet, X., Dyck, L., Hogan, A. E., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0251-7 · Cited by 624 · see citing works

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

Roberts, D. L., Dive, C., & Renehan, A. G. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.080708.082713 · Cited by 611 · see citing works

Insulin resistance and cancer risk: An overview of the pathogenetic mechanisms

Arcidiacono, B., Iiritano, S., Nocera, A., Possidente, K., Nevolo, M. T., Ventura, V., Foti, D., Chiefari, E., & Brunetti, A. (2012) · Experimental Diabetes Research · doi:10.1155/2012/789174 · Cited by 606 · see citing works

Pancreatic cancer: A review of epidemiology, trend, and risk factors

Hu, J.-X., Zhao, C., Chen, W.-B., Liu, Q., Li, Q.-W., Lin, Y., & Gao, F. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i27.4298 · Cited by 602 · see citing works

Antidiabetic Therapies Affect Risk of Pancreatic Cancer

Li, D., Yeung, S. J., Hassan, M. M., Konopleva, M., & Abbruzzese, J. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.013 · Cited by 584 · see citing works

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

Xie, H., Lim, B., & Lodish, H. F. (2009) · Diabetes · doi:10.2337/db08-1299 · Cited by 577 · see citing works

Obesity and cancer risk: evidence, mechanisms, and recommendations

Vučenik, I., & Stains, J. P. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06750.x · Cited by 572 · see citing works

Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood

Blüher, S., Schwarz, P. E. H., & Klusmann, J. (2018) · Metabolism · doi:10.1016/j.metabol.2018.12.001 · Cited by 574 · see citing works

The obese adipose tissue microenvironment in cancer development and progression

Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

Schultze, S. M., Hemmings, B. A., Nießen, M., & Tschopp, O. (2012) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002109 · Cited by 538 · see citing works

Hepatocellular carcinoma epidemiology

Bosetti, C., Turati, F., & Vecchia, C. L. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.08.007 · Cited by 531 · see citing works

Adipocyte and lipid metabolism in cancer drug resistance

Cao, Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127201 · Cited by 529 · see citing works

Non‐alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

Ertle, J., Dechêne, A., Sowa, J., Penndorf, V., Herzer, K., Kaiser, G. M., Schlaak, J., Gerken, G., Syn, W., & Canbay, A. E. (2010) · International Journal of Cancer · doi:10.1002/ijc.25797 · Cited by 519 · see citing works

Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma

Marrero, J. A., Fontana, R. J., Fu, S., Conjeevaram, H. S., Su, G. L., & Lok, A. S.-F. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.10.005 · Cited by 508 · see citing works

Obesity, inflammation, and liver cancer

Sun, B., & Karin, M. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.09.020 · Cited by 496 · see citing works

Inflammatory Links Between High Fat Diets and Diseases

Duan, Y., Zeng, L., Zheng, C., Song, B., Li, F., Kong, X., & Xu, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02649 · Cited by 495 · see citing works

Metformin in cancer therapy: a new perspective for an old antidiabetic drug?

Ben Sahra, I., Le Marchand-Brustel, Y., Tanti, J.-F., & Bost, F. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1186 · Cited by 493 · see citing works

Adiponectin and cancer: a systematic review

Kelesidis, I., Kelesidis, T., & Mantzoros, C. S. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603051 · Cited by 488 · see citing works

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

Wellen, K. E., & Thompson, C. B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.004 · Cited by 486 · see citing works

mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

Dann, S. G., Selvaraj, A., & Thomas, G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.04.002 · Cited by 481 · see citing works

Obesity and cancer risk: the role of the insulin-IGF axis

Renehan, A. G., Frystyk, J., & Flyvbjerg, A. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.08.006 · Cited by 480 · see citing works

Gut microbiota promotes obesity-associated liver cancer through pge2-mediated suppression of antitumor immunity.

Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0932 · Cited by 478 · see citing works

Body Mass Index and Risk, Age of Onset, and Survival in Patients With Pancreatic Cancer

Li, D. (2009) · JAMA · doi:10.1001/jama.2009.886 · Cited by 466 · see citing works

Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms

Alcock, J., Maley, C. C., & Aktipis, C. A. (2014) · BioEssays · doi:10.1002/bies.201400071 · Cited by 454 · see citing works

Mitogenic signaling pathways induced by G protein‐coupled receptors

Rozengurt, E. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21246 · Cited by 461 · see citing works

Annual Report to the Nation on the status of cancer, 1975‐2008, featuring cancers associated with excess weight and lack of sufficient physical activity

Eheman, C. R., Henley, S. J., Ballard-Barbash, R. R., Jacobs, E. J., Schymura, M. J., Noone, A., Pan, L., Anderson, R. N., Fulton, J. E., Kohler, B., et al. (2012) · Cancer · doi:10.1002/cncr.27514 · Cited by 455 · see citing works

Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

Peairs, K. S., Barone, B. B., Snyder, C. F., Yeh, H., Stein, K. B., Derr, R. L., Brancati, F. L., & Wolff, A. C. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.3011 · Cited by 451 · see citing works

Targeting the Circulating MicroRNA Signature of Obesity

Ortega, F. J., Mercader, J. M., Catalán, V., Moreno‐Navarrete, J. M., Pueyo, N., Sabater, M., Gómez‐Ambrosi, J., Anglada, R., Fernández‐Formoso, J. A., Ricart, W., et al. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2012.195776 · Cited by 443 · see citing works

Risk factors for pancreatic cancer: a summary review of meta-analytical studies

Maisonneuve, P., & Lowenfels, A. B. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu240 · Cited by 447 · see citing works

Obesity and Cancer Risk: Recent Review and Evidence

Basen-Engquist, K., & Chang, M. (2011) · Current Oncology Reports · doi:10.1007/s11912-010-0139-7 · Cited by 439 · see citing works

The Metabolic Syndrome

Cowey, S. L., & Hardy, R. W. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051090 · Cited by 429 · see citing works

The Epidemiology of Renal Cell Carcinoma

Lipworth, L. P., Tarone, R. E., & McLaughlin, J. K. (2006) · The Journal of Urology · doi:10.1016/j.juro.2006.07.130 · Cited by 427 · see citing works

The role of insulin receptors and IGF-I receptors in cancer and other diseases

Frasca, F., Pandini, G., Sciacca, L., PEZZINO, V., Squatrito, S., Belfiore, A., & Vigneri, R. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450801969715 · Cited by 408 · see citing works

Obesity and cancer: inflammation bridges the two

Kolb, R. H., Sutterwala, F. S., & Zhang, W. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.07.005 · Cited by 411 · see citing works

Versatile functions for IL-6 in metabolism and cancer

Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 405 · see citing works

Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies

Aune, D., Keum, N., Giovannucci, E. L., Fadnes, L. T., Boffetta, P., Greenwood, D. C., Tonstad, S., VATTEN, L. J., Ríboli, E., & Norat, T. (2016) · BMC Medicine · doi:10.1186/s12916-016-0730-3 · Cited by 402 · see citing works

Obesity and cancer: Pathophysiological and biological mechanisms

Renehan, A. G., Roberts, D. L., & Dive, C. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450801954303 · Cited by 402 · see citing works

Phosphoinositide signalling in cancer: beyond PI3K and PTEN

Bunney, T. D., & Katan, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2842 · Cited by 400 · see citing works

Cancer Incidence and Mortality After Gastric Bypass Surgery

Adams, T. D., Stroup, A. M., Gress, R. E., Adams, K. F., Calle, E. E., Smith, S. C., Halverson, R. C., Simper, S. C., Hopkins, P. N., & Hunt, S. C. (2009) · Obesity · doi:10.1038/oby.2008.610 · Cited by 393 · see citing works

Obesity and loss of disease-free years owing to major non-communicable diseases: a multicohort study

Nyberg, S. T., Batty, G. D., Pentti, J., Virtanen, M., Alfredsson, L. S., Fransson, E. I., Goldberg, M., Heikkilä, K., Jokela, M. M., Knutsson, A., et al. (2018) · The Lancet Public Health · doi:10.1016/s2468-2667(18)30139-7 · Cited by 393 · see citing works

Body Mass Index and Breast Cancer Risk According to Postmenopausal Estrogen-Progestin Use and Hormone Receptor Status

Munsell, M. F., Sprague, B. L., Berry, D. A., Chisholm, G. B., & Trentham‐Dietz, A. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxt010 · Cited by 384 · see citing works

The proliferating role of insulin and insulin-like growth factors in cancer

Gallagher, E. J., & LeRoith, D. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.06.007 · Cited by 391 · see citing works

Relation of body mass index to cancer risk in 362,552 Swedish men

Samanic, C. M., Chow, W.-H., Gridley, G., Järvholm, B., & Fraumeni, J. F. (2006) · Cancer Causes & Control · doi:10.1007/s10552-006-0023-9 · Cited by 381 · see citing works

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

Longo, V. D., & Fontana, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.004 · Cited by 378 · see citing works

Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis

Reid, B. J., Li, X., Galipeau, P. C., & Vaughan, T. L. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2773 · Cited by 377 · see citing works

Bariatric Surgery and the Risk of Cancer in a Large Multisite Cohort

Schauer, D. P., Feigelson, H. S., Koebnick, C., Caan, B., Weinmann, S., Leonard, A. C., Powers, J. D., Yenumula, P. R., & Arterburn, D. E. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000002525 · Cited by 373 · see citing works

Sexual dimorphism in cancer

Clocchiatti, A., Cora, E., Zhang, Y., & Dotto, G. P. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.30 · Cited by 368 · see citing works

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

Vallée, A., & Lecarpentier, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00745 · Cited by 352 · see citing works

Obesity and cancer

Pischon, T., Nöthlings, U., & Boeing, H. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006976 · Cited by 320 · see citing works

Epidemiological and molecular mechanisms aspects linking obesity and cancer

Osório–Costa, F., Rocha, G. Z., Dias, M. M., & Carvalheira, J. B. C. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200013 · Cited by 76 · see citing works

Obesity and cancer: Pathophysiological and biological mechanisms

Renehan, A. G., Roberts, D. L., & Dive, C. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450801954303 · Cited by 402 · see citing works

Linking Obesity, Metabolism, and Cancer

Vučenik, I., Jones, L. P., & McLenithan, J. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_50 · Cited by 3 · see citing works

Obesity as a Major Risk Factor for Cancer

Pergola, G. D., & Silvestris, F. (2013) · Journal of Obesity · doi:10.1155/2013/291546 · Cited by 964 · see citing works