Circulating Immunoreactive Cardiac Troponin Forms Determined by Gel Filtration Chromatography after Acute Myocardial Infarction
Abstract
Background: Cardiac troponin I (cTnI) and cTnT measurements are used in the diagnosis of acute myocardial infarction (AMI). Together with troponin C (TnC), the cTnI and cTnT forms make up the ternary cTnT-cTnI-TnC (TIC) complex found within myocardium. Whether cTn occurs in the circulation after AMI as ternary TIC, binary cTnI-TnC (IC) complexes, or free troponin forms has not been thoroughly investigated. Methods: Blood samples from 10 AMI patients were collected at hospital admission and then at 12, 24, and 48 h after onset of chest pain. Serum was subjected to gel filtration chromatography and cTnT (Roche cTnT) and cTnI (Siemens Centaur UltraTnI and Beckman Access AccuTnI) concentrations were measured in the gel filtration chromatography fractions. Results: cTnT was present predominantly as free cTnT and cTnI as binary IC complex. These 2 forms were present at every time point. Lesser quantities of TIC complex (6%–32% of total cTnT and <50% of total cTnI) were detected in 4 patients at varying times. Minor quantities of a high molecular mass form of cTnI were detected occasionally. No free cTnI was found. Both cTnI assays identified a similar pattern of cTnI forms. Conclusions: After AMI, cTnI is present in serum as TIC and IC complexes. cTnT may be present as a combination of TIC and free cTnT or exclusively as free cTnT.
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The peptide targets the central portion of cTnI (amino acid residues 114-144) with less susceptibility to proteolysis.
“This specific peptide (HWQIAYNEHQWQ) not only exhibits an impressive binding affinity (Kd) of 270 pM comparable to that of antibodies37, but also targets the central portion of cTnI (amino acid residues 114–144) with less susceptibility to proteolysis and is postulated to be an optimal targeting epitope to detect all forms of cTnI present in blood circulation38–40.”
From Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum (2020) · cites this paper as [39]
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« Troponines » SFBC, S. E. S., Chenevier‐Gobeaux, C., Bonnefoy‐Cudraz, E., Charpentier, S., Dehoux, M., Lefèvre, G., Meune, C., & Ray, P. (2014) · Annales françaises de médecine d’urgence · doi:10.1007/s13341-014-0423-5
- Authors
- Bates, K. J., Hall, E. M., Fahie-Wilson, M. N., Kindler, H., Bailey, C., Lythall, D., & Lamb, E. J.
- Affiliations
- East Kent Hospitals University NHS Foundation Trust (GB)
- Department of Clinical Biochemistry, Southend University Hospital NHS Foundation Trust, Southend University Hospital, Westcliff-on-Sea, Essex, UK
- Southend University Hospital NHS Foundation Trust (GB)
- Corresponding author
- Hall, Elizabeth M
- ORCID
- Lamb, Edmund J
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-01
- Volume
- 56
- Issue
- 6
- Pages
- 952-958
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2132918447
- Cited by
- 69
- References
- 18
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 1 · 2022: 12 · 2021: 5 · 2020: 10 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association for Clinical Biochemistry
- Roche
- Siemens
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- cardiac troponin I, cardiac troponin T, troponin C, acute myocardial infarction, troponin complex
- MeSH terms
- Aged, Aged, 80 and over, Chest Pain, Chromatography, Gel, Female, Humans, Male, Middle Aged, Myocardial Infarction, Time Factors, Troponin, Troponin I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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