Cited by 376Bone health and osteoporosis researchBone Metabolism and DiseasesBone health and treatments

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Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease

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Greenblatt, Matthew B, Tsai, Joy N, Wein, Marc N·2017·Clinical Chemistry

DOI 10.1373/clinchem.2016.259085PMC PMC5549920

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Abstract

BACKGROUND: Disorders of bone metabolism, most notably osteoporosis, are highly prevalent and predispose to fractures, causing high patient morbidity and mortality. Diagnosis and monitoring of bone metabolic defects can present a major challenge as these disorders are largely asymptomatic and radiographic measures of bone mass respond slowly to changes in bone physiology. CONTENT: Bone turnover markers (BTMs) are a series of protein or protein derivative biomarkers released during bone remodeling by osteoblasts or osteoclasts. BTMs can offer prognostic information on fracture risk that supplements radiographic measures of bone mass, but testing using BTMs has to take into account the large number of preanalytic factors and comorbid clinical conditions influencing BTM levels. BTMs respond rapidly to changes in bone physiology, therefore, they have utility in determining patient response to and compliance with therapies for osteoporosis. SUMMARY: BTMs are a useful adjunct for the diagnosis and therapeutic monitoring of bone metabolic disorders, but their use has to be tempered by the known limitations in their clinical utility and preanalytic variables complicating interpretation.

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Authors: Greenblatt, M. B., Tsai, J. N., & Wein, M. N.
Affiliations: Weill Cornell Medicine (US)
Massachusetts General Hospital (US)
Corresponding author: Greenblatt, Matthew B
ORCID: Greenblatt, Matthew B
Tsai, Joy N
Wein, Marc N
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2017-02-01
Volume: 63
Issue: 2
Pages: 464-474
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2016.259085
PMC: PMC5549920
OpenAlex: W2560774896
Cited by: 376
References: 97
Citations by year: 2026: 24 · 2025: 50 · 2024: 54 · 2023: 60 · 2022: 54 · 2021: 49 · 2020: 39 · 2019: 23 · 2018: 16 · 2017: 6
FWCI: 2.39
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Career Award for Medical Scientists from the Burroughs Wellcome Fund
Office of the Director of the NIH (DP5OD021351)
Junior Investigator Award from the Musculoskeletal Transplant Foundation
NIAMS of the NIH (K23AR068447, K08AR067285)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords: bone turnover markers, metabolic bone disease, osteoporosis, fracture risk, bone remodeling, osteoblasts, osteoclasts, pre-analytical variables, treatment monitoring, biomarkers
MeSH terms: Bone and Bones, Bone Diseases, Metabolic, Humans, Biomarkers, Bone Remodeling

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Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease

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