The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease
Open accessAbstract
BACKGROUND: Disorders of bone metabolism, most notably osteoporosis, are highly prevalent and predispose to fractures, causing high patient morbidity and mortality. Diagnosis and monitoring of bone metabolic defects can present a major challenge as these disorders are largely asymptomatic and radiographic measures of bone mass respond slowly to changes in bone physiology. CONTENT: Bone turnover markers (BTMs) are a series of protein or protein derivative biomarkers released during bone remodeling by osteoblasts or osteoclasts. BTMs can offer prognostic information on fracture risk that supplements radiographic measures of bone mass, but testing using BTMs has to take into account the large number of preanalytic factors and comorbid clinical conditions influencing BTM levels. BTMs respond rapidly to changes in bone physiology, therefore, they have utility in determining patient response to and compliance with therapies for osteoporosis. SUMMARY: BTMs are a useful adjunct for the diagnosis and therapeutic monitoring of bone metabolic disorders, but their use has to be tempered by the known limitations in their clinical utility and preanalytic variables complicating interpretation.
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“The most often measured resorption markers in clinical practice for the diagnosis of osteoporosis are the C-terminal telopeptide of type I collagen (ICTP), β-CrossLaps (β-CTX), and the N-terminal telopeptide of type I collagen (NTX) [56].”
From Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics (2023) · cites this paper as [56]
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“Degradation markers, such as pyridinoline (Pir) and deoxypyridinoline (Dpir), are proxy measurements for osteoclast activity.”
From Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics (2023) · cites this paper as [56]
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Cites
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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
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Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis
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Markers of bone resorption predict hip fracture in elderly women: The EPIDOS prospective study
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Endocrine Regulation of Male Fertility by the Skeleton
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Current Status of the Diagnosis and Management of Osteoporosis
Aibar-Almazán, A., Voltes-Martínez, A., Castellote-Caballero, Y., Afanador-Restrepo, D. F., Carcelén-Fraile, M. D. C., & López-Ruiz, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169465 · Cited by 412
Update on Osteoporosis Screening and Management
Anam, A. K., & Insogna, K. L. (2021) · Medical Clinics of North America · doi:10.1016/j.mcna.2021.05.016 · Cited by 244
A systematic review and meta-analysis of bone loss in space travelers
Stavnichuk, M., Mikolajewicz, N., Corlett, T., Morris, M., & Komarova, S. V. (2020) · npj Microgravity · doi:10.1038/s41526-020-0103-2 · Cited by 217
Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics
Adejuyigbe, B., Kallini, J., Chiou, D., & Kallini, J. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914583 · Cited by 148
Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review
Carnauba, R. A., Baptistella, A. B. D. P., Paschoal, V., & Hübscher, G. (2017) · Nutrients · doi:10.3390/nu9060538 · Cited by 147
Metadata
- Authors
- Greenblatt, M. B., Tsai, J. N., & Wein, M. N.
- Affiliations
- Weill Cornell Medicine (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Greenblatt, Matthew B
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-02-01
- Volume
- 63
- Issue
- 2
- Pages
- 464-474
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- PMC
- PMC5549920
- OpenAlex
- W2560774896
- Cited by
- 376
- References
- 97
- Citations by year
- 2026: 24 · 2025: 50 · 2024: 54 · 2023: 60 · 2022: 54 · 2021: 49 · 2020: 39 · 2019: 23 · 2018: 16 · 2017: 6
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Career Award for Medical Scientists from the Burroughs Wellcome Fund
- Office of the Director of the NIH (DP5OD021351)
- Junior Investigator Award from the Musculoskeletal Transplant Foundation
- NIAMS of the NIH (K23AR068447, K08AR067285)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- bone turnover markers, metabolic bone disease, osteoporosis, fracture risk, bone remodeling, osteoblasts, osteoclasts, pre-analytical variables, treatment monitoring, biomarkers
- MeSH terms
- Bone and Bones, Bone Diseases, Metabolic, Humans, Biomarkers, Bone Remodeling
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