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Cited by 133Genetic Associations and EpidemiologyLipoproteins and Cardiovascular HealthGenetics and Physical Performance

Heritabilities of Apolipoprotein and Lipid Levels in Three Countries

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Beekman, Marian, Heijmans, Bastiaan T., Martin, Nicholas G., Pedersen, Nancy L., Whitfield, John B., DeFaire, Ulf, van Baal, G. Caroline M., Snieder, Harold +3 more·2002·Twin Research
DOI 10.1375/twin.5.2.87
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Abstract

This study investigated the influence of genes and environment on the variation of apolipoprotein and lipid levels, which are important intermediate phenotypes in the pathways toward cardiovascular disease. Heritability estimates are presented, including those for apolipoprotein E and AII levels which have rarely been reported before. We studied twin samples from the Netherlands (two cohorts; n = 160 pairs, aged 13–22 and n = 204 pairs, aged 34–62), Australia ( n = 1362 pairs, aged 28–92) and Sweden ( n = 302 pairs, aged 42–88). The variation of apolipoprotein and lipid levels depended largely on the influences of additive genetic factors in each twin sample. There was no significant evidence for the influence of common environment. No sex differences in heritability estimates for any phenotype in any of the samples were observed. Heritabilities ranged from 0.48–0.87, with most heritabilities exceeding 0.60. The heritability estimates in the Dutch samples were significantly higher than in the Australian sample. The heritabilities for the Swedish were intermediate to the Dutch and the Australian samples and not significantly different from the heritabilities in these other two samples. Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries.

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Authors
Beekman, M., Heijmans, B. T., Martin, N. G., Pedersen, N. L., Whitfield, J. B., DeFaire, U., van Baal, G. C. M., Snieder, H., Vogler, G. P., Slagboom, P. E., & Boomsma, D. I.
Affiliations
  • Leiden University (NL)
  • QIMR Berghofer Medical Research Institute (AU)
  • Karolinska Institutet (SE)
  • Royal Prince Alfred Hospital (AU)
  • St Thomas' Hospital (GB)
  • Pennsylvania State University (US)
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
Beekman, Marian
ORCID
Venue
Twin Research
Publisher
Cambridge University Press (CUP)
Published
2002-04-01
Volume
5
Issue
2
Pages
87-97
ISSN
  • 1369-0523 (ISSN-L)
  • 2053-6003
DOI
10.1375/twin.5.2.87
OpenAlex
W2155644892
Cited by
133
References
0
Citations by year
2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 6
FWCI
3.37
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 3613 d)
Locations
  • Twin Research (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • VU Research Portal (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • National Heart Foundation of Australia
  • National Institutes of Health
  • National Institute on Aging (R01AG004563, AG04563)
  • National Heart, Lung, and Blood Institute (HL-55976, R01HL055976)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords
heritability, apolipoprotein E, apolipoprotein A-II, serum lipids, twin studies, additive genetic effects, shared environment, cardiovascular risk, sex differences, cross-national comparison
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Apolipoproteins E, Australia, Cardiovascular Diseases, Diseases in Twins, Female, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Netherlands, Sweden, Cohort Studies, Apolipoprotein A-II, Genetic Predisposition to Disease

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