The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Obstacles And Opportunities In Alzheimer’s Clinical Trial Recruitment
Open accessAbstract
The 2012 National Plan to Address Alzheimer's Disease set an ambitious goal: to both prevent and effectively treat Alzheimer's disease by 2025. To reach this goal, tens of thousands of volunteers will be needed to participate in clinical trials to test promising new interventions and therapies. To mobilize these volunteers and their health care providers to participate in future clinical trials, it will be necessary to achieve a better understanding of the barriers keeping people from participating in Alzheimer's research; form innovative partnerships among researchers, health care and social service providers, and the public; and develop more-effective outreach strategies. In this article we explore recruitment issues, including those unique to Alzheimer's studies, and we suggest concrete steps such as establishing a structured consortium linking all of the registries of Alzheimer's trials and establishing new partnerships with community and local organizations that can build trust and understanding among patients, caregivers, and providers.
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“critically insufficient data at preclinical and prodromal stages, particularly longitudinal biomarkers, due to low screening participation, invasive sampling requirements, and reliance on caregiver-reported cognitive changes (Watson et al., 2014)”
From Multimodal neuroimaging and AI integration in cognitive disorders: advances, challenges, and future directions for precision medicine (2026) · cites this paper as Watson et al., 2014
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2022 Alzheimer's disease facts and figures
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Metadata
- Authors
- Watson, J. L., Ryan, L., Silverberg, N., Cahan, V., & Bernard, M. A.
- Affiliations
- National Institutes of Health (US)
- National Institute on Aging (US)
- ORCID
- Bernard, Marie A.
- Venue
- Health Affairs
- Publisher
- Health Affairs Publishing, LLC
- Published
- 2014-04
- Volume
- 33
- Issue
- 4
- Pages
- 574-579
- ISSN
- 0278-2715 (ISSN-L)
- 1544-5208
- PMC
- PMC4167360
- OpenAlex
- W2044038526
- Cited by
- 204
- References
- 26
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 16 · 2023: 44 · 2022: 32 · 2021: 25 · 2020: 20 · 2019: 14 · 2018: 19 · 2017: 7 · 2016: 3
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Health Affairs (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, clinical trial recruitment, barriers to participation, research volunteers, community partnerships, outreach strategies, research registry
- MeSH terms
- Alzheimer Disease, Clinical Trials as Topic, Humans, Minority Groups, Registries, Patient Selection, Physicians, Primary Care, Asymptomatic Diseases
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