Cited by 204Ethics in Clinical ResearchDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Obstacles And Opportunities In Alzheimer’s Clinical Trial Recruitment

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Watson, Jennifer L., Ryan, Laurie, Silverberg, Nina, Cahan, Vicky, Bernard, Marie A.·2014·Health Affairs

DOI 10.1377/hlthaff.2013.1314PMC PMC4167360

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Abstract

The 2012 National Plan to Address Alzheimer's Disease set an ambitious goal: to both prevent and effectively treat Alzheimer's disease by 2025. To reach this goal, tens of thousands of volunteers will be needed to participate in clinical trials to test promising new interventions and therapies. To mobilize these volunteers and their health care providers to participate in future clinical trials, it will be necessary to achieve a better understanding of the barriers keeping people from participating in Alzheimer's research; form innovative partnerships among researchers, health care and social service providers, and the public; and develop more-effective outreach strategies. In this article we explore recruitment issues, including those unique to Alzheimer's studies, and we suggest concrete steps such as establishing a structured consortium linking all of the registries of Alzheimer's trials and establishing new partnerships with community and local organizations that can build trust and understanding among patients, caregivers, and providers.

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Authors: Watson, J. L., Ryan, L., Silverberg, N., Cahan, V., & Bernard, M. A.
Affiliations: National Institutes of Health (US)
National Institute on Aging (US)
ORCID: Bernard, Marie A.
Venue: Health Affairs
Publisher: Health Affairs Publishing, LLC
Published: 2014-04
Volume: 33
Issue: 4
Pages: 574-579
ISSN: 0278-2715 (ISSN-L)
1544-5208
DOI: 10.1377/hlthaff.2013.1314
PMC: PMC4167360
OpenAlex: W2044038526
Cited by: 204
References: 26
Citations by year: 2026: 10 · 2025: 14 · 2024: 16 · 2023: 44 · 2022: 32 · 2021: 25 · 2020: 20 · 2019: 14 · 2018: 19 · 2017: 7 · 2016: 3
FWCI: 3.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Health Affairs (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 AG999999)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, clinical trial recruitment, barriers to participation, research volunteers, community partnerships, outreach strategies, research registry
MeSH terms: Alzheimer Disease, Clinical Trials as Topic, Humans, Minority Groups, Registries, Patient Selection, Physicians, Primary Care, Asymptomatic Diseases

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Obstacles And Opportunities In Alzheimer’s Clinical Trial Recruitment

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