The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Mucins, Mucus, and Sputum
Abstract
Normal airway mucus lines the epithelial surface and provides an important innate immune function by detoxifying noxious molecules and by trapping and removing pathogens and particulates from the airway via mucociliary clearance. The major macromolecular constituents of normal mucus, the mucin glycoproteins, are large, heavily glycosylated proteins with a defining feature of tandemly repeating sequences of amino acids rich in serine and threonine, the linkage sites for large carbohydrate structures. The mucins are composed of two major families: secreted mucins and membrane-associated mucins. Membrane-associated mucins have been reported to function as cell surface receptors for pathogens and to activate intracellular signaling pathways. The biochemical and cellular functions for secreted mucin glycoproteins have not been definitively assigned. In contrast to normal mucus, sputum production is the hallmark of chronic inflammatory airway diseases such as asthma, chronic bronchitis, and cystic fibrosis (CF). Sputum has altered macromolecular composition and biophysical properties which vary with disease, but unifying features are failure of mucociliary clearance, resulting in airway obstruction, and failure of innate immune properties. Mucin glycoprotein overproduction and hypersecretion are common features of chronic inflammatory airway disease, and this has been the underlying rationale to investigate the mechanisms of mucin gene regulation and mucin secretion. However, in some pathologic conditions such as CF, airway sputum contains little intact mucin and has increased content of several macromolecules including DNA, filamentous actin, lipids, and proteoglycans. This review will highlight the most recent insights on mucus biology in health and disease.
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In the citing paper
“suggesting a virus-specific induced change on the host cell membrane to which all bacteria adhered in the same way (96, 259, 302).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
In the citing paper
“and increased pneumococcal adherence was found after prior adenovirus or rhinovirus infection of airway epithelial cells (93, 302).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
In the citing paper
“whereas measles virus and adenovirus infection decreased adherence of both bacterial species”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
In the citing paper
“Interestingly, rhinovirus preinfection enhanced staphylococcal and streptococcal adherence, whereas measles virus and adenovirus infection decreased adherence of both bacterial species”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
Citations
Cites
Interleukin-13: Central Mediator of Allergic Asthma
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Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease
Rose, M. C., & Voynow, J. A. (2005) · Physiological Reviews · doi:10.1152/physrev.00010.2005 · Cited by 1,061
Self-citationColorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936
Structure and Function of the Polymeric Mucins in Airways Mucus
Thornton, D. J., Rousseau, K., & McGuckin, M. A. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100702 · Cited by 858
Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline
Donaldson, S. H., Bennett, W. D., Zeman, K. L., Knowles, M. R., Tarran, R., & Boucher, R. C. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa043891 · Cited by 689
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Cell surface-associated mucins in signal transduction.
Singh, P., & Hollingsworth, M. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.07.006 · Cited by 434
Coordinated clearance of periciliary liquid and mucus from airway surfaces.
Matsui, H., Randell, S. H., Peretti, S. W., Davis, C. W., & Boucher, R. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2687 · Cited by 397
Normal and Cystic Fibrosis Airway Surface Liquid Homeostasis
Tarran, R., Button, B. M., Picher, M., Paradiso, A. M., Ribeiro, C. M. P., Lazarowski, E. R., Zhang, L., Collins, P. L., Pickles, R. J., Fredberg, J. J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505832200 · Cited by 356
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Items 501–506 of 506
Biasin, A., Sarro, G., Confalonieri, P., Salton, F., Confalonieri, M., Abriani, A., Campisciano, G., Comar, M., Tierno, D., Tonon, F., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146355
Respiratory mucosal vaccines for emerging viruses: promise and challenges
Beeton, K., & Case, J. B. (2026) · Journal of Virology · doi:10.1128/jvi.01748-25
Woo, T. K., Lee, H. G., & Oh, I. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7674947
Exploring the expression and function of CRTh2 in asthma
Stinson, S. (2015) · Figshare
Care of the patient with a tracheotomy
Wojnar, M. M., & McGinn, J. D. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511977787.015
Gulraiz, F. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20140522fg
Metadata
- Authors
- Voynow, J. A., & Rubin, B. K.
- Affiliations
- Duke University (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Voynow, Judith A.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 135
- Issue
- 2
- Pages
- 505-512
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2148736553
- Cited by
- 504
- References
- 84
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 17 · 2023: 26 · 2022: 17 · 2021: 27 · 2020: 33 · 2019: 27 · 2018: 28 · 2017: 34 · 2016: 27 · 2015: 39 · 2014: 44 · 2013: 45 · 2012: 40
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-65611, R01HL065611)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- mucin, mucus, sputum, mucociliary clearance, innate immunity, mucin glycosylation, secreted mucins, mucin secretion, chronic inflammatory airway diseases, asthma, chronic bronchitis, cystic fibrosis, airway obstruction, proteoglycans
- MeSH terms
- Asthma, Cystic Fibrosis, Female, Humans, Male, Mucins, Mucociliary Clearance, Mucus, Respiratory System, Sensitivity and Specificity, Sputum, Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
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